RECENT ADVANCES IN CARBOPROSTACYCLIN SYNTHESIS

Summary A different approach to the carboprostacyclin synthesis is reported where the ω-chain is introduced in the last stage of the synthetic pathway The advantages of this procedure are discussed. The bicyclo/3.3.0/-octane framework is obtained through two different routes utilizing nor-borneone and tetrahydrophtalic anhydride respectively: the latter way leads to new homocarboprostacyclins.