Apolipoprotein A-I in liver disease.

Apolipoprotein A-I and high-density lipoprotein concentrations in the plasma of patients with liver disease have been found to be either normal or lower than normal. In this study the apolipoprotein A-I concentration was measured in the plasma of 19 patients with cholestatic liver disease and 21 patients with noncholestatic liver disease. To evaluate the severity of liver disease, serum albumin, prealbumin, bilirubin, and bile salts were also measured. Apolipoprotein A-I concentrations in plasma correlated positively with serum albumin (r = 0.55, p less than 0.001) and prealbumin (r = 0.57, p less than 0.001) and negatively with serum bilirubin (r = -0.47, p less than 0.01) and bile salts (r = -0.54, p less than 0.001). The apolipoprotein A-I level thus seems to reflect the severity of liver disease. This is presumably due to a decreased liver synthesis of apolipoprotein A-I in liver disease.

[1]  C. Florén,et al.  Apolipoproteins A-I, A-II and E in cholestatic liver disease. , 1985, Scandinavian journal of clinical and laboratory investigation.

[2]  P. Berthelot,et al.  Plasma Lipoprotein and Apolipoprotein Profile in Alcoholic Patients with and without Liver Disease: On the Relative Roles of Alcohol and Liver Injury , 1984, Hepatology.

[3]  G. Kanel,et al.  High‐Density Lipoprotein Cholesterol and Liver Disease , 2007, Hepatology.

[4]  C. Malmendier,et al.  In vivo metabolism of human apoprotein A-I-phospholipid complexes. Comparison with human high density lipoprotein-apoprotein A-I metabolism. , 1983, Clinica chimica acta; international journal of clinical chemistry.

[5]  C. Blum,et al.  Apolipoprotein localization and quantitation in the human intestine. , 1982, Gastroenterology.

[6]  T. Starzl,et al.  Transport of apolipoproteins A-I and A-II by human thoracic duct lymph. , 1981, The Journal of clinical investigation.

[7]  G. Assmann,et al.  Demonstration of human apolipoprotien A in isolated mucosal cells from small intestine and isolated hepatocytes. , 1979, Gut.

[8]  J. Albers,et al.  The measurement of apolipoprotein A-I and A-II levels in men and women by immunoassay. , 1977, The Journal of clinical investigation.

[9]  P. Alaupovic,et al.  Determination of human apolipoprotein E by electroimmunoassay. , 1976, Biochimica et biophysica acta.

[10]  F. Schaffner.  Primary biliary cirrhosis. , 1975, Clinics in gastroenterology.

[11]  G. Miller,et al.  PLASMA-HIGH-DENSITY-LIPOPROTEIN CONCENTRATION AND DEVELOPMENT OF ISCHÆMIC HEART-DISEASE , 1975, The Lancet.

[12]  P. A. Peterson,et al.  Metabolism of the Vitamin A Transporting Protein Complex , 1973, Scandinavian journal of clinical and laboratory investigation.

[13]  J. Glomset,et al.  The plasma lecithins:cholesterol acyltransferase reaction. , 1968, Journal of lipid research.