Cortical areas mediating stereopsis in the human brain: a PET study

Using PET, we investigated the neural substrates of stereodepth perception in humans. The presentation of Julesz-type random-dot stereograms (RDS) produced significant rCBF elevations in Brodmann areas (BA) 18, 19 and 7, all in the right hemisphere. Activation foci were also found in both middle temporal areas (MT). These results demonstrate that, as in primates, cortical area MT and extrastriate areas are central to stereovision and that a network of predominant right hemispheric regions is recruited to meet visuo-spatial processing demands associated with horizontal binocular disparity inputs.

[1]  H. Komatsu,et al.  Disparity sensitivity of neurons in monkey extrastriate area MST , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[2]  B. G. Cumming,et al.  Responses of primary visual cortical neurons to binocular disparity without depth perception , 1997, Nature.

[3]  A. Dale,et al.  The Representation of Illusory and Real Contours in Human Cortical Visual Areas Revealed by Functional Magnetic Resonance Imaging , 1999, The Journal of Neuroscience.

[4]  G. DeAngelis,et al.  Cortical area MT and the perception of stereoscopic depth , 1998, Nature.

[5]  B. Gulyás,et al.  Binocular disparity discrimination in human cerebral cortex: functional anatomy by positron emission tomography. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Alan C. Evans,et al.  Specific Involvement of Human Parietal Systems and the Amygdala in the Perception of Biological Motion , 1996, The Journal of Neuroscience.

[7]  K Kani,et al.  Stereopsis-processing regions in the human parieto-occipital cortex , 2001, Neuroreport.

[8]  F Bremmer,et al.  Stages of self-motion processing in primate posterior parietal cortex. , 2000, International review of neurobiology.

[9]  H. Fukuyama,et al.  Functional anatomy on perception of position and motion in depth. , 1996, Neuroreport.

[10]  M. Ptito,et al.  Cortical Representation of Inward and Outward Radial Motion in Man , 2001, NeuroImage.

[11]  M. Torrens Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[12]  R. Cabeza,et al.  Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies , 2000, Journal of Cognitive Neuroscience.

[13]  T B Rothstein,et al.  Defective stereopsis in lesions of the parietal lobe. , 1972, American journal of ophthalmology.

[14]  R J Zatorre,et al.  Stereopsis after unilateral anterior temporal lobectomy. Dissociation between local and global measures. , 1991, Brain : a journal of neurology.

[15]  P E Roland,et al.  Processing and Analysis of Form, Colour and Binocular Disparity in the Human Brain: Functional Anatomy by Positron Emission Tomography , 1994, The European journal of neuroscience.

[16]  M. Goodale,et al.  The visual brain in action , 1995 .

[17]  F. A. Miles Binocular Vision and Stereopsis by Ian P. Howard and Brian J. Rogers, Oxford University Press, 1995. £90.00 (736 pages) ISBN 0 19 508476 4. , 1996, Trends in Neurosciences.

[18]  Alan C. Evans,et al.  Localization and lateralization of stereoscopic processing in the human brain. , 1993, Neuroreport.

[19]  H. Sakata,et al.  Parietal neurons represent surface orientation from the gradient of binocular disparity. , 2000, Journal of neurophysiology.

[20]  C. Baker,et al.  Processing of second-order stimuli in the visual cortex. , 2001, Progress in brain research.

[21]  Leslie G. Ungerleider,et al.  ‘What’ and ‘where’ in the human brain , 1994, Current Opinion in Neurobiology.

[22]  G. Poggio,et al.  Stereoscopic mechanisms in monkey visual cortex: binocular correlation and disparity selectivity , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[23]  R Perez,et al.  Neural mechanisms underlying stereoscopic vision , 1998, Progress in Neurobiology.

[24]  J. Winn,et al.  Brain , 1878, The Lancet.

[25]  Alan C. Evans,et al.  A Three-Dimensional Statistical Analysis for CBF Activation Studies in Human Brain , 1992, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[26]  A. Parker,et al.  Binocular Neurons in V1 of Awake Monkeys Are Selective for Absolute, Not Relative, Disparity , 1999, The Journal of Neuroscience.