Shared Genetic and Experimental Links between Obesity-Related Traits and Asthma Subtypes in UK Biobank.

[1]  L. Liang,et al.  Genetic overlap of chronic obstructive pulmonary disease and cardiovascular disease-related traits: a large-scale genome-wide cross-trait analysis , 2019, Respiratory Research.

[2]  L. Liang,et al.  Shared genetic architecture between metabolic traits and Alzheimer’s disease: a large-scale genome-wide cross-trait analysis , 2019, Human Genetics.

[3]  R. Damoiseaux,et al.  Obesity increases airway smooth muscle responses to contractile agonists. , 2018, American journal of physiology. Lung cellular and molecular physiology.

[4]  Po-Ru Loh,et al.  Mixed-model association for biobank-scale datasets , 2018, Nature Genetics.

[5]  L. Liang,et al.  A genome-wide cross trait analysis from UK Biobank highlights the shared genetic architecture of asthma and allergic diseases , 2018, Nature Genetics.

[6]  J. Bates,et al.  Beyond BMI: Obesity and Lung Disease , 2018, Chest.

[7]  Zhaozhong Zhu,et al.  Statistical power and utility of meta-analysis methods for cross-phenotype genome-wide association studies , 2018, PloS one.

[8]  Alkes L. Price,et al.  Mixed-model association for biobank-scale datasets , 2018, Nature Genetics.

[9]  T. Hansen,et al.  Estimating the causal effect of body mass index on hay fever, asthma and lung function using Mendelian randomization , 2018, Allergy.

[10]  A. Price,et al.  Distinguishing genetic correlation from causation across 52 diseases and complex traits , 2017, Nature Genetics.

[11]  Steve Epstein,et al.  Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease , 2017, Nature Genetics.

[12]  Robert M. Maier,et al.  Causal associations between risk factors and common diseases inferred from GWAS summary data , 2017, Nature Communications.

[13]  Tanya M. Teslovich,et al.  An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans , 2017, Diabetes.

[14]  Jing Wang,et al.  WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit , 2017, Nucleic Acids Res..

[15]  N. Casals,et al.  Ceramides and mitochondrial fatty acid oxidation in obesity , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[16]  M. Imboden,et al.  Heterogeneity of obesity-asthma association disentangled by latent class analysis, the SAPALDIA cohort. , 2017, Respiratory medicine.

[17]  D. Sawyer,et al.  RESEARCH Integrative Cardiovascular Physiology and Pathophysiology ERBB signaling attenuates proinflammatory activation of nonclassical monocytes , 2022 .

[18]  Stephen Burgess,et al.  Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses with Multiple Genetic Variants , 2016, Epidemiology.

[19]  Xiaofeng Zhu,et al.  Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits , 2016, Nature Genetics.

[20]  B. Brüne,et al.  Macrophage fatty acid oxidation and its roles in macrophage polarization and fatty acid-induced inflammation. , 2016, Biochimica et biophysica acta.

[21]  S. Thompson,et al.  Bias due to participant overlap in two‐sample Mendelian randomization , 2016, Genetic epidemiology.

[22]  C. Padez,et al.  Association between obesity and asthma – epidemiology, pathophysiology and clinical profile , 2016, Nutrition Research Reviews.

[23]  D. Platt,et al.  Shared genetic variants between serum levels of high-density lipoprotein cholesterol and wheezing in a cohort of children from Cyprus , 2016, Italian Journal of Pediatrics.

[24]  K. Kent,et al.  A crosstalk between TGF-β/Smad3 and Wnt/β-catenin pathways promotes vascular smooth muscle cell proliferation. , 2016, Cellular signalling.

[25]  S. Saglani,et al.  Novel concepts in airway inflammation and remodelling in asthma , 2015, European Respiratory Journal.

[26]  Yakir A Reshef,et al.  Partitioning heritability by functional annotation using genome-wide association summary statistics , 2015, Nature Genetics.

[27]  Sara M. Willems,et al.  The impact of low-frequency and rare variants on lipid levels , 2015, Nature Genetics.

[28]  F. Laurent,et al.  Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study. , 2015, American Journal of Respiratory and Critical Care Medicine.

[29]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[30]  P. Elliott,et al.  UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.

[31]  J. Yanovski,et al.  Analysis of variants and mutations in the human winged helix FOXA3 gene and associations with metabolic traits , 2015, International Journal of Obesity.

[32]  Ross M. Fraser,et al.  Genetic studies of body mass index yield new insights for obesity biology , 2015, Nature.

[33]  Peter Kraft,et al.  Adjusting for heritable covariates can bias effect estimates in genome-wide association studies. , 2015, American journal of human genetics.

[34]  Xiaofeng Zhu,et al.  Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. , 2015, American journal of human genetics.

[35]  M. Daly,et al.  LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.

[36]  Q. Zhan,et al.  ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit. , 2014, Cancer research.

[37]  J. Sterne,et al.  Effects of BMI, Fat Mass, and Lean Mass on Asthma in Childhood: A Mendelian Randomization Study , 2014, PLoS medicine.

[38]  D. Teachey,et al.  Loss of TBL1XR1 Disrupts Glucocorticoid Receptor Recruitment to Chromatin and Results in Glucocorticoid Resistance in a B-Lymphoblastic Leukemia Model* , 2014, The Journal of Biological Chemistry.

[39]  S. Wendell,et al.  Fatty acids, inflammation, and asthma. , 2014, The Journal of allergy and clinical immunology.

[40]  Sumit Ghosh,et al.  Hyaluronan deposition and co-localization with inflammatory cells and collagen in a murine model of fungal allergic asthma , 2014, Inflammation Research.

[41]  J. Whitsett,et al.  Foxa3 induces goblet cell metaplasia and inhibits innate antiviral immunity. , 2014, American journal of respiratory and critical care medicine.

[42]  F. Martinez,et al.  Asthma , 2013, The Lancet.

[43]  Y. Manios,et al.  The obesity–asthma link in different ages and the role of Body Mass Index in its investigation: findings from the Genesis and Healthy Growth Studies , 2013, Allergy.

[44]  C. Ulrik,et al.  Obesity and asthma: a coincidence or a causal relationship? A systematic review. , 2013, Respiratory medicine.

[45]  E. Bel,et al.  Adult-onset asthma: is it really different? , 2013, European Respiratory Review.

[46]  J. Stull,et al.  Signaling through Myosin Light Chain Kinase in Smooth Muscles* , 2013, The Journal of Biological Chemistry.

[47]  C. Wallace.  Statistical Testing of Shared Genetic Control for Potentially Related Traits , 2013, Genetic epidemiology.

[48]  C. Papoutsakis,et al.  Childhood overweight/obesity and asthma: is there a link? A systematic review of recent epidemiologic evidence. , 2013, Journal of the Academy of Nutrition and Dietetics.

[49]  Jake K. Byrnes,et al.  Bayesian refinement of association signals for 14 loci in 3 common diseases , 2012, Nature Genetics.

[50]  A. Hata,et al.  Targeting the TGFβ signalling pathway in disease , 2012, Nature Reviews Drug Discovery.

[51]  W. Busse,et al.  What effect does asthma treatment have on airway remodeling? Current perspectives. , 2011, Journal of Allergy and Clinical Immunology.

[52]  P. Sun,et al.  Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. , 2011, Cell metabolism.

[53]  W. Busse,et al.  Obesity and asthma: an association modified by age of asthma onset. , 2011, The Journal of allergy and clinical immunology.

[54]  L. Wood,et al.  Airway inflammation is augmented by obesity and fatty acids in asthma , 2011, European Respiratory Journal.

[55]  A. Sood.  Sex Differences: Implications for the Obesity-Asthma Association , 2011, Exercise and sport sciences reviews.

[56]  D. Jarvis,et al.  Early age at menarche, lung function, and adult asthma. , 2011, American journal of respiratory and critical care medicine.

[57]  J. Brehm,et al.  Analyses of shared genetic factors between asthma and obesity in children. , 2010, The Journal of allergy and clinical immunology.

[58]  R. Morita,et al.  Smad2 and Smad3 Are Redundantly Essential for the TGF-β–Mediated Regulation of Regulatory T Plasticity and Th1 Development , 2010, The Journal of Immunology.

[59]  D. Curran‐Everett,et al.  Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. , 2010, American journal of respiratory and critical care medicine.

[60]  Christian Gieger,et al.  New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk , 2010, Nature Genetics.

[61]  Q. Hamid,et al.  Airway remodelling in asthma: from benchside to clinical practice. , 2010, Canadian respiratory journal.

[62]  S. Royce,et al.  Effect of extracellular matrix composition on airway epithelial cell and fibroblast structure: implications for airway remodeling in asthma. , 2009, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[63]  H. Wolff,et al.  Transforming growth factor-β/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity , 2008, The British journal of dermatology.

[64]  S. Shore,et al.  Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation. , 2008, Journal of applied physiology.

[65]  M. Simmonds,et al.  The HLA Region and Autoimmune Disease: Associations and Mechanisms of Action , 2007, Current genomics.

[66]  P. Paré,et al.  Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. , 2007, The European respiratory journal.

[67]  Parvez Hossain,et al.  Obesity and diabetes in the developing world--a growing challenge. , 2007, The New England journal of medicine.

[68]  R. Adams,et al.  Central obesity is associated with nonatopic but not atopic asthma in a representative population sample. , 2006, The Journal of allergy and clinical immunology.

[69]  J. Thierry-Mieg,et al.  AceView: a comprehensive cDNA-supported gene and transcripts annotation , 2006, Genome Biology.

[70]  M. Wurfel,et al.  Genetic pleiotropy between asthma and obesity in a community-based sample of twins. , 2005, The Journal of allergy and clinical immunology.

[71]  E. Ford.  Current reviews of allergy and clinical immunology , 2005 .

[72]  P. Howarth,et al.  Expression of c-erbB receptors and ligands in the bronchial epithelium of asthmatic subjects. , 2002, The Journal of allergy and clinical immunology.

[73]  N. Kraut,et al.  Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis. , 2001, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[74]  D. Lúdvíksdóttir,et al.  Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. BHR Group. , 2000, American journal of respiratory and critical care medicine.

[75]  A. Roberts,et al.  Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF‐β , 1999, The EMBO journal.

[76]  R. Timpl,et al.  Collagen type XVI expression is modulated by basic fibroblast growth factor and transforming growth factor‐β , 1998, FEBS letters.

[77]  A. Shinagawa,et al.  Cell growth-promoting activity of tissue inhibitor of metalloproteinases-2 (TIMP-2). , 1994, Journal of cell science.