Multiple reasons for an inefficient STAT1 response upon IL-6-type cytokine stimulation.

[1]  Mamoru Tamura,et al.  Molecular dynamics of STAT3 on IL-6 signaling pathway in living cells. , 2004, Biochemical and biophysical research communications.

[2]  U. Vinkemeier,et al.  Getting the message across, STAT! Design principles of a molecular signaling circuit , 2004, The Journal of cell biology.

[3]  P. Heinrich,et al.  Janus Kinase (Jak) Subcellular Localization Revisited , 2004, Journal of Biological Chemistry.

[4]  P. Heinrich,et al.  Real Time Analysis of STAT3 Nucleocytoplasmic Shuttling* , 2004, Journal of Biological Chemistry.

[5]  A. Bosserhoff,et al.  Interferon-gamma-mediated growth regulation of melanoma cells: involvement of STAT1-dependent and STAT1-independent signals. , 2004, The Journal of investigative dermatology.

[6]  F. Horn,et al.  Analysis of Stat3 (signal transducer and activator of transcription 3) dimerization by fluorescence resonance energy transfer in living cells. , 2004, The Biochemical journal.

[7]  P. Heinrich,et al.  Principles of interleukin (IL)-6-type cytokine signalling and its regulation. , 2003, The Biochemical journal.

[8]  Rolf Rossaint,et al.  Activation of STAT3 by IL-6 and IL-10 in Primary Human Macrophages Is Differentially Modulated by Suppressor of Cytokine Signaling 3 1 , 2003, The Journal of Immunology.

[9]  J. Darnell,et al.  Signalling: STATs: transcriptional control and biological impact , 2002, Nature Reviews Molecular Cell Biology.

[10]  L. Kinnunen,et al.  Arginine/Lysine-rich Nuclear Localization Signals Mediate Interactions between Dimeric STATs and Importin α5* , 2002, The Journal of Biological Chemistry.

[11]  J. Pober,et al.  Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1-dependent Genes in Endothelial Cells , 2002, The Journal of Biological Chemistry.

[12]  I. Lödige,et al.  Constitutive and IFN‐γ‐induced nuclear import of STAT1 proceed through independent pathways , 2002 .

[13]  I. Kerr,et al.  Mapping of a Region within the N Terminus of Jak1 Involved in Cytokine Receptor Interaction* , 2001, The Journal of Biological Chemistry.

[14]  P. Bates,et al.  A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130 , 2001, FEBS letters.

[15]  V. Diehl,et al.  STAT3 is constitutively activated in Hodgkin cell lines. , 2001, Blood.

[16]  P. Heinrich,et al.  Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells. , 2001, The Biochemical journal.

[17]  G. Stark,et al.  How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene , 2000, The EMBO journal.

[18]  P. Heinrich,et al.  Cytoplasmic STAT proteins associate prior to activation. , 2000, The Biochemical journal.

[19]  V. Fried,et al.  Cellular Physiology of STAT3: Where’s the Cytoplasmic Monomer?* , 1999, The Journal of Biological Chemistry.

[20]  U. Klingmüller,et al.  Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1 , 1999, Oncogene.

[21]  I. Kerr,et al.  Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. , 1998, The Biochemical journal.

[22]  R. Simpson,et al.  STAT3 forms stable homodimers in the presence of divalent cations prior to activation. , 1998, Biochemical and biophysical research communications.

[23]  G. Yancopoulos,et al.  The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression , 1997, Current Biology.

[24]  M. David,et al.  Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine Stimulation (*) , 1996, The Journal of Biological Chemistry.

[25]  G. Müller-Newen,et al.  Soluble human interleukin-6 receptor. Expression in insect cells, purification and characterization. , 1995, European journal of biochemistry.

[26]  G. Stark,et al.  A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin‐6. , 1995, The EMBO journal.

[27]  J. Darnell,et al.  Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions , 1994, Cell.

[28]  G. Ciliberto,et al.  Single-step purification and structural characterization of human interleukin-6 produced in Escherichia coli from a T7 RNA polymerase expression vector. , 1991, European journal of biochemistry.