SPECT-CT in total hip arthroplasty.

Single photon emission computed tomography combined with computed tomography (SPECT-CT), which combines functional and anatomical imaging, provides superior spatial localization to plain radiography and is more tolerant to metallic artefacts than conventional imaging such as magnetic resonance imaging (MRI). It is increasingly used in musculoskeletal imaging to enable accurate anatomical localization of increased tracer uptake, and is particularly useful in assessing metal prosthesis and the surrounding bone following total hip arthroplasty (THA). In addition to detecting complications of THA, SPECT-CT enables multiplanar reconstruction and manipulation of imaging data, which may aid surgical planning. SPECT-CT is an important adjunct to conventional imaging in the management of post-THA complications. It is vital that radiologists are able to identify the specific features of different complications and use this novel imaging technique to guide management. In this article, the use of SPECT-CT to follow post-THA complications, including aseptic loosening, periprosthetic infection, histiocytic reactions, periprosthetic fractures, polyethylene wear, and pseudotumour formation, will be reviewed.

[1]  W. Capello,et al.  Multichannel CT Imaging of Orthopedic Hardware and Implants , 2006, Seminars in musculoskeletal radiology.

[2]  S. Ostlere,et al.  The imaging spectrum of peri-articular inflammatory masses following metal-on-metal hip resurfacing , 2008, Skeletal Radiology.

[3]  S. M. Martin,et al.  YERSINIA ENTEROCOLITICA INFECTIONS AND PORK: THE MISSING LINK , 1987, The Lancet.

[4]  A. Alavi,et al.  Role of bone scintigraphy in the evaluation and treatment of nonunited fractures: concise communication. , 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  H. Gill,et al.  Analysis of wear of retrieved metal-on-metal hip resurfacing implants revised due to pseudotumours. , 2010, The Journal of bone and joint surgery. British volume.

[6]  D. Koumoundourou,et al.  [Diagnosis of septic loosening of hip prosthesis with LeukoScan. SPECT scan with 99mTc-labeled monoclonal antibodies]. , 2005, Der Orthopade.

[7]  D. Back,et al.  INCIDENCE OF HETEROTOPIC OSSIFICATION AFTER HIP RESURFACING , 2007, ANZ journal of surgery.

[8]  R. Pilliar Powder metal-made orthopedic implants with porous surface for fixation by tissue ingrowth. , 1983, Clinical orthopaedics and related research.

[9]  J. Freed,et al.  The use of the three-phase bone scan in the early diagnosis of heterotopic ossification (HO) and in the evaluation of Didronel therapy , 1982, Paraplegia.

[10]  K. Yonenobu,et al.  Huge pelvic mass secondary to wear debris causing ureteral obstruction. , 2005, The Journal of arthroplasty.

[11]  Clifford W Colwell,et al.  Cementless femoral fixation in total hip arthroplasty. , 2010, American journal of orthopedics.

[12]  D. Robertson,et al.  Total hip prosthesis metal-artifact suppression using iterative deblurring reconstruction. , 1997, Journal of computer assisted tomography.

[13]  H. Schumacher,et al.  Heterotopic ossification mimicking acute arthritis after neurologic catastrophes. , 1977, Archives of internal medicine.

[14]  F.R.S. F.R.C.S. F.A.C.S Professor Sir John Charnley C.B.E. Low Friction Arthroplasty of the Hip , 1979, Springer Berlin Heidelberg.

[15]  A. Davies,et al.  Hip arthroplasty. Part 2: normal and abnormal radiographic findings. , 2009, Clinical radiology.

[16]  B. Masri,et al.  Intraoperative periprosthetic fractures during total hip arthroplasty. Evaluation and management. , 2008, The Journal of bone and joint surgery. American volume.

[17]  Michael O'Doherty,et al.  SNM Practice Guideline for Parathyroid Scintigraphy 4.0* , 2012, The Journal of Nuclear Medicine Technology.

[18]  Orazio Schillaci,et al.  Usefulness of hybrid SPECT/CT in 99mTc-HMPAO-labeled leukocyte scintigraphy for bone and joint infections. , 2006, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[19]  R. Iorio,et al.  Heterotopic Ossification After Hip and Knee Arthroplasty: Risk Factors, Prevention, and Treatment , 2002, The Journal of the American Academy of Orthopaedic Surgeons.

[20]  J. Callaghan,et al.  The acetabulum: a prospective study of three-phase bone and indium white blood cell scintigraphy following porous-coated hip arthroplasty. , 1990, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[21]  B. Weissman Imaging of total hip replacement. , 1997, Radiology.

[22]  J. Herbert,et al.  [Arthroplasty of the hip]. , 1952, Rhumatologie.

[23]  王满宜,et al.  Heterotopic ossification , 2004 .

[24]  W. H. Dowdeswell Evaluation and management , 1978 .

[25]  William H. Harris,et al.  Total Hip and Total Knee Replacement , 1990 .

[26]  Edward Ebramzadeh,et al.  Histological Features of Pseudotumor-like Tissues From Metal-on-Metal Hips , 2010, Clinical orthopaedics and related research.

[27]  P. Taourel,et al.  Painful infection at the site of hip prosthesis: CT imaging. , 2002, Radiology.

[28]  S. Santavirta,et al.  Aggressive granulomatous lesions after hip arthroplasty. , 1989, The Journal of bone and joint surgery. British volume.

[29]  P. Choyke,et al.  From the RSNA refresher courses: a practical approach to the cystic renal mass. , 2004, Radiographics : a review publication of the Radiological Society of North America, Inc.

[30]  F. Biggi,et al.  Periprosthetic fractures of the femur: the stability of the implant dictates the type of treatment , 2010, Journal of Orthopaedics and Traumatology.

[31]  J. Teruya,et al.  Complications of anticoagulation. , 2012, Disease-a-month : DM.

[32]  A. Liddle,et al.  Pseudotumors in association with well-functioning metal-on-metal hip prostheses: a case-control study using three-dimensional computed tomography and magnetic resonance imaging. , 2012, The Journal of bone and joint surgery. American volume.

[33]  M. Brown,et al.  Bone scintigraphy: Part 2. Orthopedic bone scanning. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[34]  D. Koumoundourou,et al.  Diagnose septischer Hüftprothesenlockerung via LeukoScan , 2005, Der Orthopäde.

[35]  C. Love,et al.  Combined labeled leukocyte and technetium 99m sulfur colloid bone marrow imaging for diagnosing musculoskeletal infection. , 2006, Radiographics : a review publication of the Radiological Society of North America, Inc.

[36]  Gerald Q. Maguire,et al.  A new CT method for measuring cup orientation after total hip arthroplastyA study of 10 patients , 2004, Acta orthopaedica Scandinavica.

[37]  David Murray,et al.  Necrotic and inflammatory changes in metal-on-metal resurfacing hip arthroplasties , 2009, Acta orthopaedica.

[38]  V. Edeline,et al.  Single photon emission tomography/computed tomography (SPET/CT) and positron emission tomography/computed tomography (PET/CT) to image cancer , 2011, Journal of surgical oncology.

[39]  J. Callaghan,et al.  Three-phase bone scan and indium white blood cell scintigraphy following porous coated hip arthroplasty: a prospective study of the prosthetic tip. , 1989, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[40]  R. Lull,et al.  Asymptomatic total hip prosthesis: natural history determined using Tc-99m MDP bone scans. , 1986, Radiology.

[41]  Johann Henckel,et al.  Pseudotumors Are Common in Well-positioned Low-wearing Metal-on-Metal Hips , 2012, Clinical Orthopaedics and Related Research.

[42]  P. Munk,et al.  Imaging of the painful hip arthroplasty. , 2003, AJR. American journal of roentgenology.

[43]  H. Malchau,et al.  Risk factors for periprosthetic femoral fracture. , 2007, Injury.

[44]  H. Amstutz,et al.  "Modes of failure" of cemented stem-type femoral components: a radiographic analysis of loosening. , 1979, Clinical orthopaedics and related research.

[45]  Javad Parvizi,et al.  Total hip arthroplasties: What are the reasons for revision? , 2008, International Orthopaedics.

[46]  Dia Shehab,et al.  Heterotopic ossification. , 2002, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[47]  S. Goodman Fixation and loosening of hip prostheses. , 1991, Acta orthopaedica Scandinavica.

[48]  E. Chang,et al.  Metal-on-metal total hip arthroplasty: do symptoms correlate with MR imaging findings? , 2012, Radiology.

[49]  W. Bautz,et al.  Assessment of aseptic loosening of the acetabular component in a total hip replacement with 99mTc-DPD-SPECT/spiral-CT hybrid imaging. , 2005, Nuklearmedizin. Nuclear medicine.

[50]  P. Gregory,et al.  Bone-ingrowth hip prostheses in asymptomatic patients: radiographic features. , 1988, Radiology.

[51]  J. Ditunno,et al.  Heterotopic ossification in the paraplegic patient. , 1971, Archives of physical medicine and rehabilitation.

[52]  S. Stea,et al.  Factors affecting aseptic loosening of 4750 total hip arthroplasties: multivariate survival analysis , 2007, BMC musculoskeletal disorders.

[53]  W H Harris,et al.  Extensive localized bone resorption in the femur following total hip replacement. , 1976, The Journal of bone and joint surgery. American volume.

[54]  B. Kristiansen,et al.  Biomechanical factors in loosening of the Stanmore hip. , 1985, Acta orthopaedica Scandinavica.

[55]  C. Krettek,et al.  Can the viability of a nonunion be evaluated using SPECT/CT? A preliminary retrospective study. , 2011, Technology and health care : official journal of the European Society for Engineering and Medicine.

[56]  D. Ragone,et al.  Heterotopic ossification masquerading as deep venous thrombosis in head-injured adult: complications of anticoagulation. , 1986, Archives of physical medicine and rehabilitation.

[57]  M W Vannier,et al.  Fast iterative algorithm for metal artifact reduction in X-ray CT. , 2000, Academic radiology.

[58]  M. Brown,et al.  Parathyroid adenomas: accurate detection and localization with Tc-99m sestamibi SPECT. , 1996, Radiology.

[59]  S. Santavirta,et al.  Cementless revision of aggressive granulomatous lesions in hip replacements. , 1990, The Journal of bone and joint surgery. British volume.

[60]  Alexander Haug,et al.  Detection of low-grade prosthetic joint infections using 99mTc-antigranulocyte SPECT/CT: initial clinical results , 2010, European Journal of Nuclear Medicine and Molecular Imaging.

[61]  K. Chiu,et al.  Review Article: Polyethylene Wear and Osteolysis in Total Hip Arthroplasty , 2001, Journal of orthopaedic surgery.

[62]  D W Murray,et al.  Pseudotumours associated with metal-on-metal hip resurfacings. , 2008, The Journal of bone and joint surgery. British volume.

[63]  C. Palestro,et al.  Radionuclide imaging in orthopedic infections. , 1997, Seminars in nuclear medicine.

[64]  B. Kollen,et al.  High incidence of pseudotumour formation after large-diameter metal-on-metal total hip replacement: a prospective cohort study. , 2012, The Journal of bone and joint surgery. British volume.

[65]  Pei-Jan Paul Lin,et al.  A review of factors that affect artifact from metallic hardware on multi-row detector computed tomography. , 2010, Current problems in diagnostic radiology.

[66]  G. Abikhzer,et al.  Necrotic pseudotumor caused by a metal-on-metal total hip prosthesis: imaging characteristics on 18F-FDG PET/CT and correlative imaging , 2011, Skeletal Radiology.

[67]  C. Pfirrmann,et al.  [CT and MRI of hip arthroplasty]. , 2014, Der Radiologe.

[68]  B. Manaster,et al.  From the RSNA refresher courses. Total hip arthroplasty: radiographic evaluation. , 1996, Radiographics : a review publication of the Radiological Society of North America, Inc.

[69]  W. Reinus,et al.  Histiocytic reaction to hip arthroplasty. , 1985, Radiology.

[70]  K. Chiu,et al.  Polyethylene wear and osteolysis in total hip arthroplasty , 2022 .

[71]  Stephen Lyman,et al.  CT Outperforms Radiography for Determination of Acetabular Cup Version after THA , 2009, Clinical orthopaedics and related research.

[72]  W H Harris,et al.  Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization. , 1993, The Journal of bone and joint surgery. American volume.

[73]  C. Lohmann,et al.  Metal-on-metal bearings and hypersensitivity in patients with artificial hip joints. A clinical and histomorphological study. , 2005, The Journal of bone and joint surgery. American volume.

[74]  J. Parvizi,et al.  Diagnosis of periprosthetic infection. , 2006, The Journal of bone and joint surgery. American volume.

[75]  S. Rabin,et al.  Problem prostheses: the radiologic evaluation of total joint replacement. , 1987, Radiographics : a review publication of the Radiological Society of North America, Inc.

[76]  P. Pellicci,et al.  Effect of aspirin on heterotopic ossification after total hip arthroplasty in men who have osteoarthrosis. , 1991, The Journal of bone and joint surgery. American volume.

[77]  D. Berry Management of periprosthetic fractures: the hip. , 2002, The Journal of arthroplasty.

[78]  R. Bourne,et al.  Ingrowth surfaces. Plasma spray coating to titanium alloy hip replacements. , 1994, Clinical orthopaedics and related research.

[79]  B. Mjöberg Fixation and loosening of hip prostheses. A review. , 1991, Acta orthopaedica Scandinavica.

[80]  V. Morris,et al.  Gallium-67 scanning in the painful total hip replacement. , 1981, Clinical radiology.

[81]  J Charnley,et al.  Arthroplasty of the hip. A new operation. , 1961, Lancet.

[82]  R Huiskes,et al.  Some fundamental aspects of human joint replacement. Analyses of stresses and heat conduction in bone-prosthesis structures. , 1980, Acta orthopaedica Scandinavica. Supplementum.

[83]  Tim B Hunter,et al.  Joint arthroplasties and prostheses. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.

[84]  M. Graham,et al.  Single Photon Emission Computed Tomography (SPECT) Should be Routinely Performed for the Detection of Parathyroid Abnormalities Utilizing Technetium-99m Sestamibi Parathyroid Scintigraphy , 2009, Clinical nuclear medicine.

[85]  T P Schmalzried,et al.  The relationship between the design, position, and articular wear of acetabular components inserted without cement and the development of pelvic osteolysis. , 1994, The Journal of bone and joint surgery. American volume.

[86]  D. Berry,et al.  Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Periprosthetic Fracture of the Femur after Total Hip Arthroplasty. Treatment and Results to Date*† , 1997 .

[87]  D J Berry,et al.  Epidemiology: hip and knee. , 1999, The Orthopedic clinics of North America.

[88]  J. Charnley,et al.  Radiological demarcation of cemented sockets in total hip replacement. , 1976, Clinical orthopaedics and related research.

[89]  J. Holland,et al.  Pseudotumours associated with metal-on-metal hip resurfacing: 10-year Newcastle experience. , 2009, Acta orthopaedica Belgica.

[90]  C. S. Low,et al.  Myocardial perfusion scintigraphy: past, present and future. , 2011, The British journal of radiology.

[91]  H. Bayhan,et al.  Role of bone scanning in the management of non-united fractures: a clinical study , 2004, European Journal of Nuclear Medicine.

[92]  J. Nuyts,et al.  The value of 18FDG-PET for the detection of infected hip prosthesis , 2003, European Journal of Nuclear Medicine and Molecular Imaging.

[93]  E. Voth,et al.  Cementless Implantation of Zweymueller-Endler Total Endoprostheses of the Hip - Clinical, Radiological and Scintigraphic Follow-Up for 2 Years , 1986, Nuklearmedizin.

[94]  Pilliar Rm,et al.  Powder metal-made orthopedic implants with porous surface for fixation by tissue ingrowth. , 1983 .

[95]  N. Friederich,et al.  Combined single-photon emission computerized tomography and conventional computerized tomography (SPECT/CT): clinical value for the knee surgeons? , 2010, Knee Surgery, Sports Traumatology, Arthroscopy.

[96]  M. Critchley,et al.  Quantitative bone scanning after asymptomatic Charnley arthroplasty. , 1994, Acta orthopaedica Scandinavica.

[97]  R. Lifeso,et al.  Triphasic bone scanning following porous-coated hip arthroplasty. , 1991, Clinical orthopaedics and related research.

[98]  T. Miller,et al.  Imaging of Hip Arthroplasty , 2006, Seminars in musculoskeletal radiology.

[99]  M. N. Smith-Petersen,et al.  ARTHROPLASTY OF THE HIP , 1939 .

[100]  H. Kim,et al.  Sequential Tc-99m MDP bone scans after cementless total hip arthroplasty in asymptomatic patients. , 1997, Clinical nuclear medicine.

[101]  S David Stulberg,et al.  Use of Helical Computed Tomography for the Assessment of Acetabular Osteolysis After Total Hip Arthroplasty , 2002, The Journal of bone and joint surgery. American volume.