Cholesteatoma of the middle ear in human patients. An ultrastructural study.

The structure of middle ear cholesteatoma obtained at surgical interventions in 12 patients was investigated by light and electron microscopy. Keratinizing squamous epithelium with underlying granulomatous, partly necrotic tissue showing signs of an acute or chronic inflammatory reaction was observed. Cholesterol clefts were only observed in two specimens in which a chronic hemorrhage was present. It is proposed that a cholesteatoma starts by immigration of epidermal tissue from the tympanic membrane. Destruction of the middle ear components and of the neighboring osseous walls results from invasion of squamous epithelium, underlying necrotizing connective tissue, and keratin.

[1]  D. Lim,et al.  Acquired Cholesteatoma , 1972 .

[2]  J. Bernstein,et al.  Middle ear mucosa in health and disease. , 1971, Archives of otolaryngology.

[3]  J. Gross,et al.  Further Studies on a Collagenase in Middle Ear Cholesteatoma , 1971, The Annals of otology, rhinology, and laryngology.

[4]  F. Linthicum,et al.  Chronic serous mastoiditis, idiopathic hemotympanum and cholesterol granuloma of the mastoid , 1969, The Laryngoscope.

[5]  M. Abramson X Collagenolytic Activity in Middle Ear Cholesteatoma , 1969 .

[6]  B. Munger,et al.  The use of oxone to facilitate specific tissue stainability following osmium fixation , 1968, The Anatomical record.

[7]  R. Cotran,et al.  A LIGHT AND ELECTRON MICROSCOPIC ANALYSIS OF VASCULAR INJURY * , 1964, Annals of the New York Academy of Sciences.

[8]  I. Friedmann THE PATHOLOGY OF SECRETORY OTITIS MEDIA. , 1963, Proceedings of the Royal Society of Medicine.

[9]  G. Palade,et al.  STUDIES ON INFLAMMATION: I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study , 1961 .

[10]  John H. Luft,et al.  IMPROVEMENTS IN EPOXY RESIN EMBEDDING METHODS , 1961, The Journal of biophysical and biochemical cytology.

[11]  L. Rüedi Cholesteatoma Formation in the Middle Ear in Animal Experiments , 1959 .

[12]  M. Moskowitz,et al.  Some observations on the pathogenesis of middle-ear cholesteatoma. , 1959, A.M.A. archives of otolaryngology.

[13]  I. Friedmann,et al.  III Epidermoid Cholesteatoma and Cholesterol Granuloma Experimental and Human , 1959, The Annals of otology, rhinology, and laryngology.

[14]  J. F. Birrell Cholesteatosis of the Attic , 1958, The Journal of Laryngology & Otology.

[15]  I. Friedmann EPIDERMOID CHOLESTEATOMA AND CHOLESTEROL GRANULOMA OF THE EAR , 1957 .