A new prognostic factor for colorectal carcinoma, thymidylate synthase, and its therapeutic significance

Expression of thymidylate synthase (TS) has been studied as a mechanism of drug resistance and a prognostic factor for various cancers.

[1]  M. Fukushima,et al.  Preparation of the antibodies against recombinant human thymidylate synthase for the detection of its intratumoral levels and the application to sensitivity-study of 5-fluorouracil. , 1997, Oncology reports.

[2]  M. Fukushima,et al.  [The correlation between thymidylate synthase expression and cytotoxicity of 5-fluorouracil in human cancer cell lines: study using polyclonal antibody against recombinant human thymidylate synthase]. , 1997, Gan to kagaku ryoho. Cancer & chemotherapy.

[3]  J. Arends,et al.  A detailed analysis of K‐ras point mutations in relation to tumor progression and survival in colorectal cancer patients , 1996, International journal of cancer.

[4]  M. Fukushima,et al.  Reduced Activity of Anabolizing Enzymes in 5‐Fluorouracil‐resistant Human Stomach Cancer Cells , 1996, Japanese journal of cancer research : Gann.

[5]  D. Smith,et al.  p53 point mutation and survival in colorectal cancer patients. , 1995, Cancer research.

[6]  W. Carney,et al.  Detection of p21ras mutations in colorectal adenomas and carcinomas by enzyme‐linked immunosorbent assay , 1995, Cancer.

[7]  G. Dardanoni,et al.  Thymidylate synthase level and DNA-ploidy pattern as possible prognostic factors in human colorectal cancer: a preliminary study. , 1995, Anticancer research.

[8]  Masaki Kitajima,et al.  Expression of Sialyl Lewisa as a new prognostic factor for patients with advanced colorectal carcinoma , 1995 .

[9]  H E Rockette,et al.  The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[10]  G. Maley,et al.  Identification of a thymidylate synthase ribonucleoprotein complex in human colon cancer cells , 1994, Molecular and cellular biology.

[11]  T. Irimura,et al.  Increased expression of sialyl Lewisx antigen correlates with poor survival in patients with colorectal carcinoma: clinicopathological and immunohistochemical study. , 1993, Cancer research.

[12]  I. D'Agnano,et al.  Flow cytometric analysis of ploidy in colorectal cancer: a multicentric experience. , 1993, British Journal of Cancer.

[13]  M. Volm,et al.  Elevated expression of thymidylate synthase in doxorubicin resistant human non small cell lung carcinomas. , 1992, Anticancer research.

[14]  P. Johnston,et al.  Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. , 1992, Cancer research.

[15]  H. Wieand,et al.  DNA ploidy and cell kinetic measurements as predictors of recurrence and survival in stages B2 and C colorectal adenocarcinoma , 1991, Cancer.

[16]  S. Hakomori,et al.  Sialosyl‐Tn. A novel mucin antigen associated with prognosis in colorectal cancer patients , 1990, Cancer.

[17]  F. Berger,et al.  Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy. , 1987, Cancer treatment reports.

[18]  C. Heidelberger,et al.  In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas. , 1982, Cancer research.

[19]  S. Hsu,et al.  The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. , 1981, American journal of clinical pathology.

[20]  C. Dukes,et al.  The classification of cancer of the rectum , 1980 .

[21]  P. Danenberg.  Thymidylate synthetase - a target enzyme in cancer chemotherapy. , 1977, Biochimica et biophysica acta.

[22]  F. Schabel.  Surgical adjuvant chemotherapy of metastatic murine tumors , 1977, Cancer.

[23]  F. Schabel.  Concepts for treatment of micrometastases developed in murine systems. , 1976, AJR. American journal of roentgenology.

[24]  C. Heidelberger,et al.  Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides. , 1974, Biochemistry.

[25]  D. Santi,et al.  Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. , 1974, Biochemistry.

[26]  G. Maley,et al.  The effect of methotrexate on enzymes induced following partial hepatectomy. , 1969, Cancer research.

[27]  掛下 伸一,et al.  Non Parametric Estimationについて , 1965 .

[28]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[29]  N. Shepherd,et al.  p53 and Rb1 protein expression: are they prognostically useful in colorectal cancer? , 1997, British Journal of Cancer.

[30]  S. Groshen,et al.  Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[31]  D. Smith,et al.  Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas. , 1996, British Journal of Cancer.

[32]  W. Washtien.  Increased levels of thymidylate synthetase in cells exposed to 5-fluorouracil. , 1984, Molecular pharmacology.

[33]  D.,et al.  Regression Models and Life-Tables , 2022 .