STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway

[1]  M. Hengstschläger,et al.  Insights into Differentiation of Melanocytes from Human Stem Cells and Their Relevance for Melanoma Treatment , 2020, Cancers.

[2]  G. Ferbeyre,et al.  STAT3 and STAT5 Activation in Solid Cancers , 2019, Cancers.

[3]  B. Kamińska,et al.  Knockdown of STAT3 targets a subpopulation of invasive melanoma stem‐like cells , 2019, Cell biology international.

[4]  C. Goding,et al.  MITF—the first 25 years , 2019, Genes & development.

[5]  W. Mikulits,et al.  Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma , 2019, International journal of molecular sciences.

[6]  M. Borad,et al.  Hepatocytes direct the formation of a pro-metastatic niche in the liver. , 2019, Nature.

[7]  J. Utikal,et al.  SOX2‐mediated upregulation of CD24 promotes adaptive resistance toward targeted therapy in melanoma , 2018, International journal of cancer.

[8]  D. Barkan,et al.  EMT and Stemness in Tumor Dormancy and Outgrowth: Are They Intertwined Processes? , 2018, Front. Oncol..

[9]  P. Lu,et al.  IL22RA1/STAT3 Signaling Promotes Stemness and Tumorigenicity in Pancreatic Cancer. , 2018, Cancer research.

[10]  R. Weinberg,et al.  Emerging Biological Principles of Metastasis , 2017, Cell.

[11]  Lung-Ji Chang,et al.  Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells. , 2016, The Journal of clinical investigation.

[12]  G. Freeman,et al.  Learning from PD-1 Resistance: New Combination Strategies. , 2016, Trends in molecular medicine.

[13]  H. Kwan,et al.  Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma , 2016, Scientific Reports.

[14]  D. Levy,et al.  STAT3 regulated ARF expression suppresses prostate cancer metastasis , 2015, Nature Communications.

[15]  Steven J. M. Jones,et al.  Genomic Classification of Cutaneous Melanoma , 2015, Cell.

[16]  Ganesh Rao,et al.  FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. , 2015, Cancer research.

[17]  S. Aerts,et al.  Decoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state , 2015, Nature Communications.

[18]  K. Flaherty,et al.  MITF Modulates Therapeutic Resistance through EGFR Signaling , 2015, The Journal of investigative dermatology.

[19]  Johannes Zuber,et al.  Disruption of STAT3 signalling promotes KRAS-induced lung tumorigenesis , 2015, Nature Communications.

[20]  G. McArthur,et al.  Phenotype Switching in Melanoma: Implications for Progression and Therapy , 2015, Front. Oncol..

[21]  D. Peeper,et al.  Phenotype switching: tumor cell plasticity as a resistance mechanism and target for therapy. , 2014, Cancer research.

[22]  S. Srivastava,et al.  Critical role of STAT3 in melanoma metastasis through anoikis resistance , 2014, Oncotarget.

[23]  R. Moon,et al.  WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. , 2014, The Journal of clinical investigation.

[24]  F. Egberts,et al.  DNp73 exerts function in metastasis initiation by disconnecting the inhibitory role of EPLIN on IGF1R-AKT/STAT3 signaling. , 2013, Cancer cell.

[25]  A. Martínez-Torteya,et al.  SurvExpress: An Online Biomarker Validation Tool and Database for Cancer Gene Expression Data Using Survival Analysis , 2013, PloS one.

[26]  V. Bonazzi,et al.  Secretome from senescent melanoma engages the STAT3 pathway to favor reprogramming of naive melanoma towards a tumor-initiating cell phenotype , 2013, Oncotarget.

[27]  J. Chabon,et al.  Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates. , 2013, Immunity.

[28]  M. G. Carter,et al.  Jak/Stat3 Signaling Promotes Somatic Cell Reprogramming by Epigenetic Regulation , 2012, Stem cells.

[29]  R. Ballotti,et al.  Biological and mathematical modeling of melanocyte development , 2011, Development.

[30]  M. Mazumdar,et al.  A High Proliferative Index of Recurrent Melanoma Is Associated with Worse Survival , 2011, Oncology.

[31]  C. Bertolotto,et al.  Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma , 2011, Oncogene.

[32]  L. Akslen,et al.  Ki-67 expression is superior to mitotic count and novel proliferation markers PHH3, MCM4 and mitosin as a prognostic factor in thick cutaneous melanoma , 2010, BMC Cancer.

[33]  E. Casanova,et al.  Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. , 2010, Gastroenterology.

[34]  C. Print,et al.  A Gene Expression Signature of Invasive Potential in Metastatic Melanoma Cells , 2009, PloS one.

[35]  Yutaka Kawakami,et al.  Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. , 2009, Cancer cell.

[36]  P. Nuciforo,et al.  Brn-2 represses microphthalmia-associated transcription factor expression and marks a distinct subpopulation of microphthalmia-associated transcription factor-negative melanoma cells. , 2008, Cancer research.

[37]  L. Poling,et al.  Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage , 2008, Pigment cell & melanoma research.

[38]  C. Deng,et al.  Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling , 2008, Proceedings of the National Academy of Sciences.

[39]  R. Dummer,et al.  In vivo switching of human melanoma cells between proliferative and invasive states. , 2008, Cancer research.

[40]  B. Dréno,et al.  Loss of oncostatin M receptor β in metastatic melanoma cells , 2007, Oncogene.

[41]  Jane Goodall,et al.  Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. , 2006, Genes & development.

[42]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[43]  T. Golub,et al.  Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma , 2005, Nature.

[44]  Hua Yu,et al.  Targeting STAT3 affects melanoma on multiple fronts , 2005, Cancer Metastasis Review.

[45]  A. Trumpp,et al.  Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. , 2005, Cancer research.

[46]  N. Copeland,et al.  Melanocytes and the microphthalmia transcription factor network. , 2004, Annual review of genetics.

[47]  L. Larue,et al.  SP-14 Cre-mediated recombination in the skin melanocyte lineage , 2003 .

[48]  V. Poli,et al.  Essential Role of STAT3 in the Control of the Acute-Phase Response as Revealed by Inducible Gene Activation in the Liver , 2001, Molecular and Cellular Biology.

[49]  R. Ballotti,et al.  Direct Regulation of the Microphthalmia Promoter by Sox10 Links Waardenburg-Shah Syndrome (WS4)-associated Hypopigmentation and Deafness to WS2* , 2000, The Journal of Biological Chemistry.

[50]  K. Bille,et al.  Regulation of the Microphthalmia-associated Transcription Factor Gene by the Waardenburg Syndrome Type 4 Gene,SOX10 * , 2000, The Journal of Biological Chemistry.

[51]  M. Jaroszeski,et al.  Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. , 1999, Cancer research.

[52]  M. Katsuki,et al.  STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells , 1999, The EMBO journal.

[53]  U. Klingmüller,et al.  Interleukin-6 and oncostatin M-induced growth inhibition of human A375 melanoma cells is STAT-dependent and involves upregulation of the cyclin-dependent kinase inhibitor p27/Kip1 , 1999, Oncogene.

[54]  K. Tobita,et al.  CCAAT/enhancer-binding protein delta gene expression is mediated by APRF/STAT3. , 1997, Journal of biochemistry.

[55]  L. Chin,et al.  Role of the INK4a Locus in Tumor Suppression and Cell Mortality , 1996, Cell.

[56]  S. Shibahara,et al.  Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene , 1994, Molecular and cellular biology.

[57]  James A. Vaught,et al.  microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family. , 1994, Genes & development.

[58]  A. Jemal,et al.  Cancer statistics, 2016 , 2016, CA: a cancer journal for clinicians.

[59]  Michael R Hamblin,et al.  CA : A Cancer Journal for Clinicians , 2011 .

[60]  B. Dréno,et al.  Loss of oncostatin M receptor beta in metastatic melanoma cells. , 2007, Oncogene.

[61]  Gabriella,et al.  Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. , 2001, Molecular and cellular biology.

[62]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.