MRMR optimized classification for automatic glaucoma diagnosis

Min-Redundancy Max-Relevance (mRMR) is a feature selection methodology based on information theory. We explore the mRMR principle for automatic glaucoma diagnosis. Optimal candidate feature sets are acquired from a composition of clinical screening data and retinal fundus image data. An mRMR optimized classifier is further trained using the candidate feature sets to find the optimized classifier. We tested the proposed methodology on eye records of 650 subjects collected from Singapore Eye Research Institute. The experimental results demonstrate that the new classifier is much compact by using less than ¼ of the initial feature set. The ranked feature set also enables the clinicians to better access the diagnostic process of the algorithm. The work is a further step towards the advancement of the automatic glaucoma diagnosis.

[1]  Joachim Hornegger,et al.  The papilla as screening parameter for early diagnosis of glaucoma. , 2008, Deutsches Arzteblatt international.

[2]  Fuhui Long,et al.  Feature selection based on mutual information criteria of max-dependency, max-relevance, and min-redundancy , 2003, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[3]  R. Fisher THE USE OF MULTIPLE MEASUREMENTS IN TAXONOMIC PROBLEMS , 1936 .

[4]  Joel S Schuman,et al.  Optic nerve head and retinal nerve fiber layer analysis: a report by the American Academy of Ophthalmology. , 2007, Ophthalmology.

[5]  H R Taylor,et al.  Prevalence and predictors of open-angle glaucoma: results from the visual impairment project. , 2001, Ophthalmology.

[6]  Haizhou Li,et al.  ARGALI: An Automatic Cup-to-Disc Ratio Measurement System for Glaucoma Analysis Using Level-set Image Processing , 2009 .

[7]  Yoav Freund,et al.  A decision-theoretic generalization of on-line learning and an application to boosting , 1995, EuroCOLT.

[8]  K. Yanashima,et al.  Development of a simple diagnostic method for the glaucoma using ocular Fundus pictures. , 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

[9]  Corinna Cortes,et al.  Support-Vector Networks , 1995, Machine Learning.

[10]  Tien Yin Wong,et al.  ORIGA-light: An online retinal fundus image database for glaucoma analysis and research , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[11]  T. Wong,et al.  Rationale and Methodology for a Population-Based Study of Eye Diseases in Malay People: The Singapore Malay Eye Study (SiMES) , 2007, Ophthalmic epidemiology.

[12]  N.M. Tan,et al.  Intelligent fusion of cup-to-disc ratio determination methods for glaucoma detection in ARGALI , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.