Cortical Contributions to Saccadic Suppression

The stability of visual perception is partly maintained by saccadic suppression: the selective reduction of visual sensitivity that accompanies rapid eye movements. The neural mechanisms responsible for this reduced perisaccadic visibility remain unknown, but the Lateral Geniculate Nucleus (LGN) has been proposed as a likely site. Our data show, however, that the saccadic suppression of a target flashed in the right visual hemifield increased with an increase in background luminance in the left visual hemifield. Because each LGN only receives retinal input from a single hemifield, this hemifield interaction cannot be explained solely on the basis of neural mechanisms operating in the LGN. Instead, this suggests that saccadic suppression must involve processing in higher level cortical areas that have access to a considerable part of the ipsilateral hemifield.

[1]  C. Blakemore,et al.  The site of saccadic suppression , 2004, Nature Neuroscience.

[2]  Ignacio Vallines,et al.  Saccadic Suppression of Retinotopically Localized Blood Oxygen Level-Dependent Responses in Human Primary Visual Area V1 , 2006, The Journal of Neuroscience.

[3]  K. Hoffmann,et al.  Neural Mechanisms of Saccadic Suppression , 2002, Science.

[4]  Frank Bremmer,et al.  Neural Correlates of Visual Localization and Perisaccadic Mislocalization , 2003, Neuron.

[5]  M. Paradiso,et al.  Neural Correlates of Perceived Brightness in the Retina, Lateral Geniculate Nucleus, and Striate Cortex , 1999, The Journal of Neuroscience.

[6]  D. Burr,et al.  Selective suppression of the magnocellular visual pathway during saccadic eye movements , 1994, Nature.

[7]  Bart Krekelberg,et al.  The Relationship between Saccadic Suppression and Perceptual Stability , 2009, Current Biology.

[8]  G. Rees,et al.  Saccades Differentially Modulate Human LGN and V1 Responses in the Presence and Absence of Visual Stimulation , 2005, Current Biology.

[9]  R. Wurtz.  Neuronal mechanisms of visual stability , 2008, Vision Research.

[10]  F A Wichmann,et al.  Ning for Helpful Comments and Suggestions. This Paper Benefited Con- Siderably from Conscientious Peer Review, and We Thank Our Reviewers the Psychometric Function: I. Fitting, Sampling, and Goodness of Fit , 2001 .

[11]  R. Reid,et al.  Saccadic Eye Movements Modulate Visual Responses in the Lateral Geniculate Nucleus , 2002, Neuron.

[12]  A. F. Rossi,et al.  The representation of brightness in primary visual cortex. , 1996, Science.

[13]  Bart Krekelberg,et al.  Neural Correlates of Saccadic Suppression in Humans , 2004, Current Biology.

[14]  M. Morrone,et al.  Extraretinal Control of Saccadic Suppression , 2000, The Journal of Neuroscience.

[15]  Michael R. Ibbotson,et al.  Saccadic Modulation of Neural Responses: Possible Roles in Saccadic Suppression, Enhancement, and Time Compression , 2008, The Journal of Neuroscience.

[16]  Michael Erb,et al.  Transcranial magnetic stimulation in the visual system. II. Characterization of induced phosphenes and scotomas , 2004, Experimental Brain Research.

[17]  Geraint Rees,et al.  Extraretinal saccadic signals in human LGN and early retinotopic cortex , 2006, NeuroImage.

[18]  J. Malpeli,et al.  The representation of the visual field in the lateral geniculate nucleus of Macaca mulatta , 1975, The Journal of comparative neurology.

[19]  D. Burr,et al.  Selective depression of motion sensitivity during saccades. , 1982, The Journal of physiology.