Recent Developments of High-Resolution Chemical Imaging Systems Based on Light-Addressable Potentiometric Sensors (LAPSs)

A light-addressable potentiometric sensor (LAPS) is a semiconductor electrochemical sensor based on the field-effect which detects the variation of the Nernst potential on the sensor surface, and the measurement area is defined by illumination. Thanks to its light-addressability feature, an LAPS-based chemical imaging sensor system can be developed, which can visualize the two-dimensional distribution of chemical species on the sensor surface. This sensor system has been used for the analysis of reactions and diffusions in various biochemical samples. In this review, the LAPS system set-up, including the sensor construction, sensing and substrate materials, modulated light and various measurement modes of the sensor systems are described. The recently developed technologies and the affecting factors, especially regarding the spatial resolution and temporal resolution are discussed and summarized, and the advantages and limitations of these technologies are illustrated. Finally, the further applications of LAPS-based chemical imaging sensors are discussed, where the combination with microfluidic devices is promising.

[1]  Ping Wang,et al.  Microfluidic chip system integrated with light addressable potentiometric sensor (LAPS) for real-time extracellular acidification detection , 2019 .

[2]  De-Wen Zhang,et al.  A bioelectronic taste sensor based on bioengineered Escherichia coli cells combined with ITO-constructed electrochemical sensors. , 2019, Analytica chimica acta.

[3]  Chia-Ming Yang,et al.  Thin-film light-addressable potentiometric sensor with SnOx as a photosensitive semiconductor , 2019, Vacuum.

[4]  A IGZO-based light-addressable potentiometric sensor on a PET susbtrate , 2019, 2019 IEEE International Conference on Flexible and Printable Sensors and Systems (FLEPS).

[5]  Jian Wang,et al.  Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. , 2019, Analytical chemistry.

[6]  J. Gooding,et al.  Light-Addressable Ion Sensing for Real-Time Monitoring of Extracellular Potassium. , 2018, Angewandte Chemie.

[7]  M. Schöning,et al.  Improved spatial resolution of the chemical imaging sensor with a hybrid illumination that suppresses lateral diffusion of photocarriers , 2018, Sensors and Actuators B: Chemical.

[8]  Jian Wang,et al.  Surface modification and construction of LAPS towards biosensing applications , 2018, Sensors and Actuators B: Chemical.

[9]  Tsung-Cheng Chen,et al.  Spatial resolution and 2D chemical image of light-addressable potentiometric sensor improved by inductively coupled-plasma reactive-ion etching , 2017 .

[10]  M. Schöning,et al.  Lateral resolution enhancement of pulse-driven light-addressable potentiometric sensor , 2017 .

[11]  Differential imaging of the metabolism of bacteria and eukaryotic cells based on light-addressable potentiometric sensors , 2017 .

[12]  De-Wen Zhang,et al.  LAPS and SPIM Imaging Using ITO-Coated Glass as the Substrate Material. , 2017, Analytical chemistry.

[13]  L. Shanshan,et al.  Light-addressable potentiometric sensor with gold nanoparticles enhancing enzymatic silver deposition for 1,5-anhydroglucitol determination , 2017 .

[14]  Arshak Poghossian,et al.  Light-Addressable Potentiometric Sensors for Quantitative Spatial Imaging of Chemical Species. , 2017, Annual review of analytical chemistry.

[15]  De-Wen Zhang,et al.  Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopy , 2017, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[16]  Jin-Ming Lin,et al.  Microfluidic technologies in cell isolation and analysis for biomedical applications. , 2017, The Analyst.

[17]  Thomas Thundat,et al.  Metabolic Study of Cancer Cells Using a pH Sensitive Hydrogel Nanofiber Light Addressable Potentiometric Sensor. , 2017, ACS sensors.

[18]  M. Schöning,et al.  Visualization of the recovery process of defects in a cultured cell layer by chemical imaging sensor , 2016 .

[19]  D. Pijanowska,et al.  P-I-N amorphous silicon for thin-film light-addressable potentiometric sensors , 2016 .

[20]  S. Krause,et al.  Image Detection of Yeast Saccharomyces Cerevisiae By Light-Addressable Potentiometric Sensors (LAPS) , 2016 .

[21]  Chao‐Sung Lai,et al.  IGZO Thin-Film Light-Addressable Potentiometric Sensor , 2016, IEEE Electron Device Letters.

[22]  G. Sukhorukov,et al.  The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy , 2016 .

[23]  Takuya Sato,et al.  Light-Addressable Potentiometric Sensor as a Sensing Element in Plug-Based Microfluidic Devices , 2016, Micromachines.

[24]  Chunsheng Wu,et al.  Sensing of double-stranded DNA molecules by their intrinsic molecular charge using the light-addressable potentiometric sensor , 2016 .

[25]  Yong Huang,et al.  Highly sensitive covalently functionalized light-addressable potentiometric sensor for determination of biomarker. , 2016, Materials science & engineering. C, Materials for biological applications.

[26]  Thomas Thundat,et al.  The detection of Escherichia coli (E. coli) with the pH sensitive hydrogel nanofiber-light addressable potentiometric sensor (NF-LAPS) , 2016 .

[27]  Gustave Savourey,et al.  Physiological stress monitoring using sodium ion potentiometric microsensors for sweat analysis , 2016 .

[28]  T. Yoshinobu,et al.  A Novel Data Acquisition Method for Visualization of Large pH Changes by Chemical Imaging Sensor , 2016 .

[29]  M. Schöning,et al.  Application of chemical imaging sensor to in-situ pH imaging in the vicinity of a corroding metal surface , 2015 .

[30]  Anirban Das,et al.  Analog micromirror-LAPS for chemical imaging and zoom-in application , 2015 .

[31]  J. Gautrot,et al.  High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers , 2015 .

[32]  Chunsheng Wu,et al.  Label-free detection of DNA using a light-addressable potentiometric sensor modified with a positively charged polyelectrolyte layer. , 2015, Nanoscale.

[33]  Anirban Das,et al.  Sensing and pH-imaging properties of niobium oxide prepared by rapid thermal annealing for electrolyte–insulator–semiconductor structure and light-addressable potentiometric sensor , 2015 .

[34]  Michael J. Schöning,et al.  Recent developments of chemical imaging sensor systems based on the principle of the light-addressable potentiometric sensor , 2015 .

[35]  Ko-ichiro Miyamoto,et al.  Device simulation of the light-addressable potentiometric sensor for the investigation of the spatial resolution , 2014 .

[36]  Anirban Das,et al.  A high-speed, flexible-scanning chemical imaging system using a light-addressable potentiometric sensor integrated with an analog micromirror , 2014 .

[37]  M. Schöning,et al.  Theoretical study and simulation of light‐addressable potentiometric sensors , 2014 .

[38]  Chunsheng Wu,et al.  Label‐free electrical detection of DNA with a multi‐spot LAPS: First step towards light‐addressable DNA chips , 2014 .

[39]  Michael J. Schöning,et al.  Label‐Free Sensing of Biomolecules with Field‐Effect Devices for Clinical Applications , 2014 .

[40]  Ping Wang,et al.  Design of a novel hybrid sensor with microelectrode array and LAPS for heavy metal determination using multivariate nonlinear calibration , 2014 .

[41]  Michael J. Schöning,et al.  Novel photoexcitation method for light-addressable potentiometric sensor with higher spatial resolution , 2014 .

[42]  Yen-Heng Lin,et al.  Miniaturized amorphous-silicon based chemical imaging sensor system using a mini-projector as a simplified light-addressable scanning source , 2014 .

[43]  M. Schöning,et al.  Enhancement of the Spatial Resolution of the Chemical Imaging Sensor by a Hybrid Fiber-Optic Illumination , 2014 .

[44]  M. Schöning,et al.  Device Simulation of the Light-addressable Potentiometric Sensor with a Novel Photoexcitation Method for a Higher Spatial Resolution☆ , 2014 .

[45]  Anirban Das,et al.  Ultra-high scanning speed chemical image sensor based on light addressable potentiometric sensor with analog micro-mirror , 2013, 2013 IEEE SENSORS.

[46]  Michael J. Schöning,et al.  Visualization of enzymatic reaction in a microfluidic channel using chemical imaging sensor , 2013 .

[47]  M. Schöning,et al.  Chemical imaging of the concentration profile of ion diffusion in a microfluidic channel , 2013 .

[48]  T. Yoshinobu,et al.  High-speed chemical imaging inside a microfluidic channel , 2013, 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII).

[49]  High-speed chemical imaging system based on front-side-illuminated LAPS , 2013 .

[50]  M. Schöning,et al.  Frequency behaviour of light‐addressable potentiometric sensors , 2013 .

[51]  Chi-Hang Chin,et al.  LAPS with nanoscaled and highly polarized HfO2 by CF4 plasma for NH4+ detection , 2013 .

[52]  R. Lin,et al.  GaN Thin Film Based Light Addressable Potentiometric Sensor for pH Sensing Application , 2013 .

[53]  Qingjun Liu,et al.  A novel microphysiometer based on high sensitivity LAPS and microfluidic system for cellular metabolism study and rapid drug screening. , 2013, Biosensors & bioelectronics.

[54]  Frédéric Ginot,et al.  Study of field effect transistors for the sodium ion detection using fluoropolysiloxane-based sensitive layers , 2013 .

[55]  K. Sawada,et al.  Comparison of label-free ACh-imaging sensors based on CCD and LAPS , 2013 .

[56]  Anirban Das,et al.  A Simple and Convenient Set-Up of Light Addressable Potentiometric Sensors (LAPS) for Chemical Imaging Using a Commercially Available Projector as a Light Source , 2013 .

[57]  Yunfang Jia,et al.  Graphene oxide modified light addressable potentiometric sensor and its application for ssDNA monitoring. , 2012, The Analyst.

[58]  Da Ha,et al.  Novel structured light-addressable potentiometric sensor array based on PVC membrane for determination of heavy metals , 2012 .

[59]  Michael J. Schöning,et al.  Development and characterisation of a compact light-addressable potentiometric sensor (LAPS) based on the digital light processing (DLP) technology for flexible chemical imaging , 2012 .

[60]  Yang Liu,et al.  Unlabeled multi tumor marker detection system based on bioinitiated light addressable potentiometric sensor. , 2012, The Analyst.

[61]  Jae-Hyuk Ahn,et al.  Integration of field effect transistor-based biosensors with a digital microfluidic device for a lab-on-a-chip application. , 2012, Lab on a chip.

[62]  M. Schöning,et al.  High speed and high resolution chemical imaging based on a new type of OLED-LAPS set-up , 2012 .

[63]  Xizeng Feng,et al.  Bio-initiated light addressable potentiometric sensor for unlabeled biodetection and its MEDICI simulation. , 2011, The Analyst.

[64]  Sheng-Shian Li,et al.  Effects of CF4 Plasma Treatment on pH and pNa Sensing Properties of Light-Addressable Potentiometric Sensor with a 2-nm-Thick Sensitive HfO2 Layer Grown by Atomic Layer Deposition , 2011 .

[65]  M. Schöning,et al.  Utilising Digital Micro-Mirror Device (DMD) as Scanning Light Source for Light-Addressable Potentiometric Sensors (LAPS) , 2011 .

[66]  A. Bratov,et al.  Recent trends in potentiometric sensor arrays--a review. , 2010, Analytica chimica acta.

[67]  Michael J. Schöning,et al.  Differential Setup of Light-Addressable Potentiometric Sensor with an Enzyme Reactor in a Flow Channel , 2010 .

[68]  P. Schmuki,et al.  High resolution LAPS and SPIM , 2010 .

[69]  Michael J. Schöning,et al.  Image correction method for the chemical imaging sensor , 2010 .

[70]  Michael J. Schöning,et al.  Miniaturized chemical imaging sensor system using an OLED display panel , 2010 .

[71]  Arshak Poghossian,et al.  Use of information visualization methods eliminating cross talk in multiple sensing units investigated for a light-addressable potentiometric sensor. , 2010, Analytical chemistry.

[72]  Chao‐Sung Lai,et al.  Light Addressable Potentiometric Sensor with Fluorine-Terminated Hafnium Oxide Layer for Sodium Detection , 2009 .

[73]  Michael J. Schöning,et al.  A high-density multi-point LAPS set-up using a VCSEL array and FPGA control , 2009 .

[74]  Michael J. Schöning,et al.  Layer-by-Layer Assembly of Carbon Nanotubes Incorporated in Light-Addressable Potentiometric Sensors , 2009 .

[75]  S. Kanoh,et al.  Phase-mode LAPS and its application to chemical imaging , 2009, TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference.

[76]  Michael J. Schöning,et al.  Chemical image scanner based on FDM-LAPS , 2009 .

[77]  S. Ingebrandt,et al.  Field-effect devices for detecting cellular signals. , 2009, Seminars in cell & developmental biology.

[78]  P. Schmuki,et al.  Repair of thin thermally grown silicon dioxide by anodic oxidation , 2008 .

[79]  Ping Wang,et al.  Line-scanning LAPS array for measurement of heavy metal ions with micro-lens array based on MEMS , 2008 .

[80]  Michael J. Schöning,et al.  Handheld multi-channel LAPS device as a transducer platform for possible biological and chemical multi-sensor applications , 2007 .

[81]  J. Chazalviel,et al.  Scanning photoinduced impedance microscopy using amorphous silicon photodiode structures. , 2007, Analytical chemistry.

[82]  Michael J. Schöning,et al.  Chapter 5 Light-addressable potentiometric sensors (LAPS): recent trends and applications , 2007 .

[83]  Michael J. Schöning,et al.  PLD-prepared cadmium sensors based on chalcogenide glasses—ISFET, LAPS and μISE semiconductor structures , 2006 .

[84]  Michael J. Schöning,et al.  Bio FEDs (Field‐Effect Devices): State‐of‐the‐Art and New Directions , 2006 .

[85]  A. Sabot,et al.  Scanning Photo-Induced Impedance Microscopy - Resolution studies and polymer characterization , 2006 .

[86]  H. Men,et al.  A novel electronic tongue combined MLAPS with stripping voltammetry for environmental detection , 2005 .

[87]  Y. Ermolenko,et al.  The light-addressable potentiometric sensor for multi-ion sensing and imaging. , 2005, Methods.

[88]  Qintao Zhang,et al.  Theoretical analysis and design of submicron-LAPS , 2005 .

[89]  Hiroshi Iwasaki,et al.  Fabrication of Thin-Film LAPS with Amorphous Silicon , 2004, Sensors (Basel, Switzerland).

[90]  Hiroshi Iwasaki,et al.  Laser-scanned silicon transducer (LSST) as a multisensor system , 2004 .

[91]  Michael J. Schöning,et al.  High resolution LAPS using amorphous silicon as the semiconductor material , 2004 .

[92]  Y. Vlasov,et al.  Potentiometric and theoretical studies of the carbonate sensors based on 3-bromo-4-hexyl-5-nitrotrifluoroacetophenone. , 2004, The Analyst.

[93]  Hiroshi Iwasaki,et al.  Immobilization of Urease and Cholinesterase on the Surface of Semiconductor Transducer for the Development of Light-Addressable Potentiometric Sensors , 2004 .

[94]  Hiroshi Iwasaki,et al.  Portable light-addressable potentiometric sensor (LAPS) for multisensor applications , 2003 .

[95]  Y. Vlasov,et al.  Analytical characteristics and sensitivity mechanisms of electrolyte-insulator-semiconductor system-based chemical sensors—a critical review , 2003, Analytical and bioanalytical chemistry.

[96]  Hiroshi Iwasaki,et al.  Anion-selective light-addressable potentiometric sensors (LAPS) for the determination of nitrate and sulphate ions , 2003 .

[97]  M George,et al.  Spatially resolved monitoring of cellular metabolic activity with a semiconductor-based biosensor. , 2003, Biosensors & bioelectronics.

[98]  T. Katsube,et al.  Integration of bienzymatic disaccharide sensors for simultaneous determination of disaccharides by means of light addressable potentiometric sensor , 2002 .

[99]  Hiroshi Iwasaki,et al.  Photocurable membranes for ion-selective light-addressable potentiometric sensor , 2002 .

[100]  Ming Xu,et al.  Scanning photo-induced impedance microscopy—an impedance based imaging technique , 2002 .

[101]  Hiroshi Iwasaki,et al.  Lithium sensor based on the laser scanning semiconductor transducer , 2002 .

[102]  Hiroshi Iwasaki,et al.  Ion-selective light-addressable potentiometric sensor (LAPS) with chalcogenide thin film prepared by pulsed laser deposition , 2001 .

[103]  Michael J. Schöning,et al.  Penicillin detection by means of field-effect based sensors: EnFET, capacitive EIS sensor or LAPS? , 2001 .

[104]  Hiroshi Iwasaki,et al.  Alternative sensor materials for light-addressable potentiometric sensors , 2001 .

[105]  W. Ping,et al.  A novel microphysiometer based on MLAPS for drugs screening. , 2001, Biosensors & bioelectronics.

[106]  Hiroshi Iwasaki,et al.  Constant-Current-Mode LAPS (CLAPS) for the Detectionof Penicillin , 2001 .

[107]  Wolfgang J. Parak,et al.  A novel design of multi-light LAPS based on digital compensation of frequency domain , 2001 .

[108]  Hans Lueth,et al.  Semiconductor-based field-effect structures for chemical sensing , 2001, SPIE Optics East.

[109]  Hiroshi Iwasaki,et al.  Investigation of pulsed laser-deposited Al2O3 as a high pH-sensitive layer for LAPS-based biosensing applications , 2000 .

[110]  Wolfgang J. Parak,et al.  Investigation of the spatial resolution of the light-addressable potentiometric sensor , 2000 .

[111]  Wolfgang J. Parak,et al.  Can the light-addressable potentiometric sensor (LAPS) detect extracellular potentials of cardiac myocytes? , 2000, IEEE Transactions on Biomedical Engineering.

[112]  I Gerhardt,et al.  Photocurrent measurements for laterally resolved interface characterization , 2000, Fresenius' journal of analytical chemistry.

[113]  F. Hafner,et al.  Cytosensor Microphysiometer: technology and recent applications. , 2000, Biosensors & bioelectronics.

[114]  Hiroshi Iwasaki,et al.  Application of the pH-Imaging Sensor to Determining the Diffusion Coefficients of Ions in Electrolytic Solutions , 2000 .

[115]  Izumi Kubo,et al.  Novel sensors for potassium, calcium and magnesium ions based on a silicon transducer as a light-addressable potentiometric sensor , 1999 .

[116]  I. Karube,et al.  BIOSENSORS BASED ON LIGHT-ADDRESSABLE POTENTIOMETRIC SENSORS FOR UREA, PENICILLIN AND GLUCOSE , 1998 .

[117]  Yoshitaka Ito,et al.  High-spatial resolution LAPS , 1998 .

[118]  P. Ciampolini,et al.  Numerical analysis of ISFET and LAPS devices , 1997 .

[119]  Wolfgang J. Parak,et al.  Lateral resolution of light-addressable potentiometric sensors: an experimental and theoretical investigation , 1997 .

[120]  J. Eijkel,et al.  A general model to describe the electrostatic potential at electrolyte oxide interfaces , 1996 .

[121]  Willi Zander,et al.  A highly long-term stable silicon-based pH sensor fabricated by pulsed laser deposition technique , 1996 .

[122]  Hiroshi Iwasaki,et al.  High-resolution pH imaging sensor for microscopic observation of microorganisms , 1996 .

[123]  Hiroshi Iwasaki,et al.  Chemical-imaging sensor using enzyme , 1996 .

[124]  M. Yokoyama,et al.  Silicone-rubber membrane sodium-ion sensors based on calix[4]arene neutral carriers , 1995 .

[125]  Hiroshi Iwasaki,et al.  Observation of microorganism colonies using a scanning-laser-beam pH-sensing microscope , 1995 .

[126]  M. Yokoyama,et al.  Comparison between silicone-rubber membranes and plasticized poly(vinyl chloride) membranes containing calix[4]arene ionophores for sodium ion-sensitive field-effect transistors in applicability to sodium assay in human body fluids , 1994 .

[127]  Hiroshi Iwasaki,et al.  Scanning laser beam semiconductor pH imaging sensor , 1994 .

[128]  Teruaki Katsube,et al.  Integrated biosensor employing a surface photovoltage technique , 1994 .

[129]  Luc J. Bousse,et al.  Micromachined multichannel systems for the measurement of cellular metabolism , 1994 .

[130]  M. Nakao,et al.  Improvement of Spatial Resolution of a Laser-Scanning pH-Imaging Sensor , 1994 .

[131]  J. W. Parce,et al.  The light-addressable potentiometric sensor: principles and biological applications. , 1994, Annual review of biophysics and biomolecular structure.

[132]  J. W. Parce,et al.  The cytosensor microphysiometer: biological applications of silicon technology. , 1992, Science.

[133]  Claudio Nicolini,et al.  Minority carrier diffusion length effects on light-addressable potentiometric sensor (LAPS) devices , 1992 .

[134]  John C. Owicki,et al.  Silicon micromachining in the fabrication of biosensors using living cells , 1990, IEEE 4th Technical Digest on Solid-State Sensor and Actuator Workshop.

[135]  J. V. D. Heuvel,et al.  Diffusion length measurements of thin amorphous silicon layers , 1989 .

[136]  J. W. Parce,et al.  Light-addressable potentiometric sensor for biochemical systems. , 1988, Science.

[137]  C. Munakata,et al.  A scanning photon microscope for non-destructive observations of crystal defect and interface trap distributions in silicon wafers , 1988 .

[138]  J. Meindl,et al.  Surface Potential-pH Characteristics in the Theory of the Oxide-Electrolyte Interface , 1987 .

[139]  W. Ko,et al.  A generalized theory of an electrolyte-insulator-semiconductor field-effect transistor , 1986, IEEE Transactions on Electron Devices.

[140]  D. E. Yates,et al.  Site-binding model of the electrical double layer at the oxide/water interface , 1974 .