Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses.
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[1] K. Tung,et al. Tolerance mechanism in experimental ovarian and gastric autoimmune diseases. , 1992, Journal of immunology.
[2] Manuela Battaglia,et al. Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor β, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells , 2002, The Journal of experimental medicine.
[3] S. Yamagiwa,et al. A Role for TGF-β in the Generation and Expansion of CD4+CD25+ Regulatory T Cells from Human Peripheral Blood1 , 2001, The Journal of Immunology.
[4] R. Badolato,et al. X‐chromosome inactivation analysis in a female carrier of FOXP3 mutation , 2002, Clinical and experimental immunology.
[5] H. Weiner,et al. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. , 1994, Science.
[6] D. Zélénika,et al. Regulatory T Cells Overexpress a Subset of Th2 Gene Transcripts1 , 2002, The Journal of Immunology.
[7] E. Shevach. Regulatory T cells in autoimmmunity*. , 2000, Annual review of immunology.
[8] J. Shimizu,et al. Naturally anergic and suppressive CD25(+)CD4(+) T cells as a functionally and phenotypically distinct immunoregulatory T cell subpopulation. , 2000, International immunology.
[9] M. Toda,et al. Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. , 1998, International immunology.
[10] H. Cantor,et al. Differential cytokine requirements for regulation of autoimmune gastritis and colitis by CD4(+)CD25(+) T cells. , 2001, Journal of autoimmunity.
[11] E. Shevach,et al. CD4+CD25+ T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells. , 1998, Journal of immunology.
[12] S. Sakaguchi,et al. Organ-specific autoimmune disease induced in mice by elimination of T cell subsets. V. Neonatal administration of cyclosporin A causes autoimmune disease. , 1989, Journal of immunology.
[13] R. Steinman,et al. Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells , 2003, The Journal of experimental medicine.
[14] Yan Zhou,et al. Normal regulatory alpha/beta T cells effectively eliminate abnormally activated T cells lacking the interleukin 2 receptor beta in vivo. , 1999 .
[15] I. Caramalho,et al. Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide , 2003, The Journal of experimental medicine.
[16] T. Mak,et al. Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. , 1999, Journal of immunology.
[17] A. Bowcock,et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. , 2000, The Journal of clinical investigation.
[18] Thomas A. Davis,et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[19] S. Sakaguchi,et al. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease , 1985, The Journal of experimental medicine.
[20] J. Demengeot,et al. CD25+CD4+ regulatory T cells suppress CD4+ T cell‐mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice , 2002 .
[21] Akemi Sakamoto,et al. CD25+CD4+ T cells contribute to the control of memory CD8+ T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[22] A. Naji,et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.
[23] W. Irvine,et al. Spontaneous thyroiditis in thymectomized and irradiated Wistar rats. , 1973, Clinical and experimental immunology.
[24] A. Iellem,et al. Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells , 2001, The Journal of experimental medicine.
[25] C. Janeway,et al. Innate immune recognition. , 2002, Annual review of immunology.
[26] D. Greiner,et al. Adoptive transfer of autoimmune diabetes and thyroiditis to athymic rats. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[27] Jeffrey A. Bluestone,et al. Opinion-regulatory lymphocytes: Natural versus adaptive regulatory T cells , 2003, Nature Reviews Immunology.
[28] A. Coutinho,et al. A Model for Developmentally Acquired Thymus‐Dependent Tolerance to Central and Peripheral Antigens , 1996, Immunological reviews.
[29] P. Bruggen,et al. Tumor antigens recognized by T lymphocytes. , 1994, Annual review of immunology.
[30] J. Todd,et al. Differential glycosylation of interleukin 2, the molecular basis for the NOD Idd3 type 1 diabetes gene? , 2000, Cytokine.
[31] H. Waldmann,et al. Regulating the immune response to transplants. a role for CD4+ regulatory cells? , 2001, Immunity.
[32] Anna Chodos,et al. Antigen-dependent Proliferation of CD4+ CD25+ Regulatory T Cells In Vivo , 2003, The Journal of experimental medicine.
[33] W. Irvine,et al. Thyroiditis in T cell-depleted rats: suppression of the autoallergic response by reconstitution with normal lymphoid cells. , 1976, Clinical and experimental immunology.
[34] J. Shimizu,et al. Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance , 2002, Nature Immunology.
[35] T. Malek,et al. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. , 2002, Immunity.
[36] M. Byrne,et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. , 2002, Immunity.
[37] Ethan M. Shevach,et al. CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production , 1998, The Journal of experimental medicine.
[38] L. Klein,et al. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[39] F. Powrie,et al. Control of intestinal inflammation by regulatory T cells , 2001, Immunological reviews.
[40] T. Schumacher,et al. Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses , 2001, The Journal of experimental medicine.
[41] David Klatzmann,et al. CD4+CD25+ Immunoregulatory T Cells , 2002, The Journal of experimental medicine.
[42] K. Rajewsky,et al. Interleukin-10-deficient mice develop chronic enterocolitis , 1993, Cell.
[43] David F. Richards,et al. In Vitro Generation of Interleukin 10–producing Regulatory CD4+ T Cells Is Induced by Immunosuppressive Drugs and Inhibited by T Helper Type 1 (Th1)– and Th2-inducing Cytokines , 2002, The Journal of experimental medicine.
[44] H. Ochs,et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 , 2001, Nature Genetics.
[45] D. Mason,et al. CD25 Is a Marker for CD4+ Thymocytes That Prevent Autoimmune Diabetes in Rats, But Peripheral T Cells with This Function Are Found in Both CD25+ and CD25− Subpopulations1 , 2000, The Journal of Immunology.
[46] A. Rudensky,et al. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells , 2003, Nature Immunology.
[47] W. van Eden,et al. Anergic T cells actively suppress T cell responses via the antigen‐presenting cell , 1998, European journal of immunology.
[48] S. Sakaguchi,et al. Role of genetic factors in organ-specific autoimmune diseases induced by manipulating the thymus or T cells, and not self-antigens. , 2000, Reviews in immunogenetics.
[49] A. Enk,et al. Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells , 2000, The Journal of experimental medicine.
[50] C. Fathman,et al. The Subpopulation of CD4+CD25+ Splenocytes That Delays Adoptive Transfer of Diabetes Expresses L-Selectin and High Levels of CCR71 , 2002, The Journal of Immunology.
[51] W. Strober,et al. Cell Contact–Dependent Immunosuppression by Cd4+Cd25+Regulatory T Cells Is Mediated by Cell Surface–Bound Transforming Growth Factor β , 2001, The Journal of experimental medicine.
[52] F. Ramsdell,et al. An essential role for Scurfin in CD4+CD25+ T regulatory cells , 2003, Nature Immunology.
[53] A. Abbas,et al. Homeostasis and self-tolerance in the immune system: turning lymphocytes off. , 1998, Science.
[54] S. Akira,et al. Toll-like receptors. , 2003, Annual review of immunology.
[55] J. Bluestone,et al. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. , 2000, Immunity.
[56] V. Godfrey,et al. X-linked lymphoreticular disease in the scurfy (sf) mutant mouse. , 1991, The American journal of pathology.
[57] S. Morse,et al. Virus and autoimmunity: induction of autoimmune disease in mice by mouse T lymphotropic virus (MTLV) destroying CD4+ T cells. , 1999, Journal of immunology.
[58] I. Horak,et al. Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting , 1991, Nature.
[59] R. Coffman,et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. , 1993, International immunology.
[60] Y. Belkaid,et al. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity , 2002, Nature.
[61] M. Papiernik. Natural CD4+ CD25+ regulatory T cells. Their role in the control of superantigen responses , 2001, Immunological reviews.
[62] S. Sakaguchi,et al. Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells. , 1992, Journal of immunology.
[63] E. Shevach. Certified Professionals , 2001, The Journal of experimental medicine.
[64] C. Boitard,et al. T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice , 1989, The Journal of experimental medicine.
[65] A. Khoruts,et al. Generation of Anergic and Potentially Immunoregulatory CD25+CD4 T Cells In Vivo After Induction of Peripheral Tolerance with Intravenous or Oral Antigen1 , 2001, The Journal of Immunology.
[66] W. Heath,et al. Self‐Ignorance in the Peripheral T‐Cell Pool , 1993, Immunological reviews.
[67] T. Takahashi,et al. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis , 1982, The Journal of experimental medicine.
[68] W. Weigle. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. , 1980, Advances in immunology.
[69] S. Sakaguchi,et al. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation , 1996, The Journal of experimental medicine.
[70] T. Nomura,et al. Control of Regulatory T Cell Development by the Transcription Factor Foxp3 , 2002 .
[71] Jing Wu,et al. B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40 , 1993, Nature.
[72] H. Boehmer,et al. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes , 1988, Nature.
[73] M. Toda,et al. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. , 1995, Journal of immunology.
[74] Ruslan Medzhitov,et al. Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells , 2003, Science.
[75] S. Sakaguchi,et al. Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer , 1982, The Journal of experimental medicine.
[76] T. Mak,et al. Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4 , 2000, The Journal of experimental medicine.
[77] P. Marrack,et al. T cell tolerance by clonal elimination in the thymus , 1987, Cell.
[78] S. Sakaguchi. Control of Immune Responses by Naturally Arising CD4+ Regulatory T Cells That Express Toll-like Receptors , 2003, The Journal of experimental medicine.
[79] Fiona Powrie,et al. An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation , 1999, The Journal of experimental medicine.
[80] L. Klein,et al. Origin of regulatory T cells with known specificity for antigen , 2002, Nature Immunology.
[81] H. Ochs,et al. Immune dysregulation, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis , 2003, Current opinion in rheumatology.
[82] S. Sakaguchi. Regulatory T cells , 2000, Cell.
[83] A. Rudensky,et al. Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo , 2002, Nature Immunology.
[84] A. Cumano,et al. Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment1 , 2000, The Journal of Immunology.
[85] Y. Kohno,et al. Autoimmune thyroiditis induced in mice depleted of particular T cell subsets. I. Requirement of Lyt-1 dull L3T4 bright normal T cells for the induction of thyroiditis. , 1988, Journal of immunology.
[86] F. Otsuka,et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. , 1999, Journal of immunology.
[87] Y. Zhai,et al. What is the role of regulatory T cells in transplantation tolerance? , 1999, Current opinion in immunology.
[88] J. Bluestone,et al. Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation. , 2001, Annual review of immunology.
[89] Ethan M. Shevach,et al. CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor β1 Production and Responsiveness , 2002, The Journal of experimental medicine.
[90] M. A. Curotto de Lafaille,et al. CD4(+) regulatory T cells in autoimmunity and allergy. , 2002, Current opinion in immunology.
[91] A. Freitas,et al. Homeostasis of Peripheral CD4+ T Cells: IL-2Rα and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers1 , 2002, The Journal of Immunology.
[92] F. Powrie,et al. Regulatory T cells in the control of immune pathology , 2001, Nature Immunology.
[93] F. Alt,et al. Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. , 1995, Immunity.
[94] J. Klein. Origin of major histocompatibility complex polymorphism: the trans-species hypothesis. , 1987, Human immunology.
[95] P. A. Peterson,et al. Induction of autoimmune disease in mice by germline alteration of the T cell receptor gene expression. , 1994, Journal of immunology.
[96] D. Greiner,et al. Depletion of RT6.1+ T lymphocytes induces diabetes in resistant biobreeding/Worcester (BB/W) rats , 1987, The Journal of experimental medicine.
[97] T. Laufer,et al. Major Histocompatibility Complex Class II–Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells , 2001, The Journal of experimental medicine.
[98] J. Lafaille,et al. Interleukin 2 Signaling Is Required for CD4+ Regulatory T Cell Function , 2002, The Journal of experimental medicine.
[99] Fiona Powrie,et al. Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation , 2000, The Journal of experimental medicine.
[100] Alf Hamann,et al. Expression of the integrin αEβ7 identifies unique subsets of CD25+ as well as CD25− regulatory T cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[101] Sayuri Yamazaki,et al. Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance , 2001, Immunological reviews.
[102] K. Wood,et al. Regulatory lymphocytes: Regulatory T cells in transplantation tolerance , 2003, Nature Reviews Immunology.
[103] Hervé Groux,et al. A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis , 1997, Nature.
[104] S. Sakaguchi,et al. Animal models of autoimmunity and their relevance to human diseases. , 2000, Current opinion in immunology.
[105] M. Moser,et al. CD4+ CD25+ Regulatory T Cells Control T Helper Cell Type 1 Responses to Foreign Antigens Induced by Mature Dendritic Cells In Vivo , 2003, The Journal of experimental medicine.
[106] M. Cooke,et al. Self-tolerance checkpoints in B lymphocyte development. , 1995, Advances in immunology.
[107] L. Ignatowicz,et al. Peptide Specificity of Thymic Selection of CD4+CD25+ T Cells , 2002, The Journal of Immunology.
[108] D. Hudrisier,et al. Preferential Recognition of Self Antigens Despite Normal Thymic Deletion of CD4+CD25+ Regulatory T Cells1 , 2002, The Journal of Immunology.
[109] J. Miyazaki,et al. Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression1 , 2002, The Journal of Immunology.
[110] Ethan M. Shevach,et al. Suppressor Effector Function of CD4+CD25+ Immunoregulatory T Cells Is Antigen Nonspecific , 2000, The Journal of Immunology.
[111] J. Lamb,et al. Notch signalling in the regulation of peripheral immunity , 2001, Immunological reviews.
[112] D. Mason,et al. Regulatory T Cells in the Control of Autoimmunity: the Essential Role of Transforming Growth Factor β and Interleukin 4 in the Prevention of Autoimmune Thyroiditis in Rats by Peripheral CD4+CD45RC− Cells and CD4+CD8− Thymocytes , 1999, The Journal of experimental medicine.
[113] B. Powell,et al. An X-linked syndrome of diarrhea, polyendocrinopathy, and fatal infection in infancy. , 1982, The Journal of pediatrics.
[114] D. Galas,et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse , 2001, Nature Genetics.
[115] S. Larson,et al. Positron emission tomography imaging for herpes virus infection: Implications for oncolytic viral treatments of cancer , 2001, Nature Medicine.
[116] P. Linsley,et al. Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[117] R. Flavell,et al. Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease , 2000 .
[118] Varuna Aluvihare,et al. B cells and professional APCs recruit regulatory T cells via CCL4 , 2001, Nature Immunology.
[119] H. Hall,et al. CD4+CD25+ regulatory T cells down‐regulate co‐stimulatory molecules on antigen‐presenting cells , 2000, European journal of immunology.
[120] F. Powrie,et al. CD38+ CD45RBlow CD4+ T cells: a population of T cells with immune regulatory activities in vitro , 1998, European journal of immunology.
[121] Luc J. Smink,et al. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease , 2003, Nature.
[122] E. Shevach,et al. Cutting Edge: Control of CD8+ T Cell Activation by CD4+CD25+ Immunoregulatory Cells , 2001, The Journal of Immunology.
[123] J. Casanova,et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy , 2001, Nature Genetics.
[124] T. Fujita,et al. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody. , 1999, Cancer research.
[125] J. Watson,et al. CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells , 1993, The Journal of experimental medicine.
[126] H. Kikutani,et al. Increased T Cell Autoreactivity in the Absence of CD40-CD40 Ligand Interactions: A Role of CD40 in Regulatory T Cell Development1 , 2001, The Journal of Immunology.
[127] R. Lechler,et al. Anergic T cells as suppressor cells in vitro. , 1994, Science.
[128] J. Shimizu,et al. Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity. , 1999, Journal of immunology.
[129] T. Sakakura,et al. Thymus and Reproduction: Sex-Linked Dysgenesia of the Gonad after Neonatal Thymectomy in Mice , 1969, Science.
[130] F. Burnet. The clonal selection theory of acquired immunity , 1959 .
[131] R. Coffman,et al. A critical role for transforming growth factor-beta but not interleukin 4 in the suppression of T helper type 1-mediated colitis by CD45RB(low) CD4+ T cells , 1996, The Journal of experimental medicine.
[132] Katsuaki Sato,et al. Modified myeloid dendritic cells act as regulatory dendritic cells to induce anergic and regulatory T cells. , 2003, Blood.
[133] G. Schönrich,et al. Multiple levels of peripheral tolerance. , 1993, Immunology today.
[134] OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset [published erratum appears in J Exp Med 1991 Apr 1;173(4):1037] , 1990, The Journal of experimental medicine.
[135] T. Sasazuki,et al. Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance. , 2003, Novartis Foundation symposium.
[136] C. Fathman,et al. CD4+CD25+ T Cells Facilitate the Induction of T Cell Anergy , 2001, The Journal of Immunology.