Advanced age and liability to oxaliplatin‐induced peripheral neuropathy: post hoc analysis of a prospective study

The aim of this post hoc analysis of data extracted from a prospective, multicenter study is to test in a large homogenous population of chemotherapy‐naïve patients with colorectal cancer (CRC) treated with oxaliplatin (OXA)‐based chemotherapy whether advanced age increases the risk of developing OXA‐induced peripheral neuropathy (OXAIPN).

[1]  Cristina Santos,et al.  Peripheral neurotoxicity of oxaliplatin in combination with 5-fluorouracil (FOLFOX) or capecitabine (XELOX): a prospective evaluation of 150 colorectal cancer patients. , 2012, Annals of oncology : official journal of the European Society for Medical Oncology.

[2]  A. Carrato,et al.  Oxaliplatin in combination with infusional 5-fluorouracil as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumors. , 2012, Clinical colorectal cancer.

[3]  Guido Cavaletti,et al.  Chemotherapy-induced peripheral neurotoxicity (CIPN): an update. , 2012, Critical reviews in oncology/hematology.

[4]  Kyung-Yung Lee,et al.  Comparative analysis of the efficacy and safety of chemotherapy with oxaliplatin plus fluorouracil/leucovorin between elderly patients over 65 years and younger patients with advanced gastric cancer , 2012, Gastric Cancer.

[5]  Joon-Oh Park,et al.  Oxaliplatin-Induced Chronic Peripheral Neurotoxicity: A Prospective Analysis in Patients with Colorectal Cancer , 2010, Cancer research and treatment : official journal of Korean Cancer Association.

[6]  A. Argyriou,et al.  Integrin beta‐3 L33P: a new insight into the pathogenesis of chronic oxaliplatin‐induced peripheral neuropathy? , 2010, European journal of neurology.

[7]  A. Argyriou,et al.  Toxic peripheral neuropathy associated with commonly used chemotherapeutic agents. , 2010, Journal of B.U.ON. : official journal of the Balkan Union of Oncology.

[8]  G. Cavaletti,et al.  Chemotherapy-Induced Peripheral Neurotoxicity assessment: a critical revision of the currently available tools. , 2010, European journal of cancer.

[9]  A. Carrato,et al.  Elderly patients with advanced colorectal cancer derive similar benefit without excessive toxicity after first-line chemotherapy with oxaliplatin-based combinations: comparative outcomes from the 03-TTD-01 phase III study. , 2009, Critical reviews in oncology/hematology.

[10]  Y. Bang,et al.  Capecitabine plus oxaliplatin (XELOX) versus 5-fluorouracil/folinic acid plus oxaliplatin (FOLFOX-4) as second-line therapy in metastatic colorectal cancer: a randomized phase III noninferiority study. , 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

[11]  A. Argyriou,et al.  A review on oxaliplatin-induced peripheral nerve damage. , 2008, Cancer treatment reviews.

[12]  C. Tournigand,et al.  FOLFOX in patients aged between 76 and 80 years with metastatic colorectal cancer , 2007, Cancer.

[13]  A. Caraceni,et al.  The Total Neuropathy Score as an assessment tool for grading the course of chemotherapy‐induced peripheral neurotoxicity: comparison with the National Cancer Institute‐Common Toxicity Scale , 2007, Journal of the peripheral nervous system : JPNS.

[14]  Shari Bolen,et al.  Provider roles in the recruitment of underrepresented populations to cancer clinical trials , 2007, Cancer.

[15]  A. Argyriou,et al.  Incidence and characteristics of peripheral neuropathy during oxaliplatin-based chemotherapy for metastatic colon cancer , 2007, Acta oncologica.

[16]  C. Tournigand,et al.  Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[17]  A. Argyriou,et al.  Is advanced age associated with increased incidence and severity of chemotherapy-induced peripheral neuropathy? , 2006, Supportive Care in Cancer.

[18]  M. Dimopoulos,et al.  Irinotecan or oxaliplatin combined with leucovorin and 5-fluorouracil as first-line treatment in advanced colorectal cancer: a multicenter, randomized, phase II study. , 2005, Annals of oncology : official journal of the European Society for Medical Oncology.

[19]  L. Siu,et al.  Systematic review of barriers to the recruitment of older patients with cancer onto clinical trials. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[20]  K. Kiura,et al.  An overview of 48 elderly-specific clinical trials of systemic chemotherapy for advanced non-small cell lung cancer. , 2004, Lung cancer.

[21]  T. Hickish,et al.  Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. , 2004, The New England journal of medicine.

[22]  Laurence L. George,et al.  The Statistical Analysis of Failure Time Data , 2003, Technometrics.

[23]  B Møller,et al.  Cancer mortality trends in the EU and acceding countries up to 2015. , 2003, Annals of oncology : official journal of the European Society for Medical Oncology.

[24]  J. Kalbfleisch,et al.  The Statistical Analysis of Failure Time Data: Kalbfleisch/The Statistical , 2002 .

[25]  C. Lynch,et al.  Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[26]  D. Ceballos,et al.  Influence of aging on peripheral nerve function and regeneration , 2000, Journal of the peripheral nervous system : JPNS.

[27]  Ronald S. Sims,et al.  Neuroimmune Networks , 1990, Neurology.

[28]  A. Smith Clinical trials , 1984, The Medical journal of Australia.

[29]  C. Bokemeyer,et al.  Tolerance to chemotherapy in elderly patients with cancer. , 2007, Cancer control : journal of the Moffitt Cancer Center.

[30]  G. Creemers,et al.  First-Line Treatment Strategies for Elderly Patients with Metastatic Colorectal Cancer , 2007, Drugs & aging.

[31]  Jasper R. Daube,et al.  Electrodiagnosis in Diseases of Nerve and Muscle: Principles and Practice , 1983 .