Simultaneous ultrasonic measurement of carotid blood flow and intracerebral haemodynamics in man.

Common carotid blood flow and middle cerebral artery velocities were determined simultaneously by using a range gated Doppler velocimeter and transcranial apparatus in ten subjects. Middle cerebral artery velocities were used as an index of cerebral resistance. Different gas mixture concentrations were breathed in order to change cerebral haemodynamic conditions. In each condition there was a simultaneous modification of blood gases and cervicocerebral haemodynamics in common carotid blood flow and cerebral vascular resistance index. Carotid blood flow and the resistance index in middle cerebral artery changed also on opposite side. Acute hypercapnia in normoxia increases common carotid blood flow by 33% and simultaneously decreases cerebral resistance index by 11%. Normocapnic hyperoxia was associated with a fall in common carotid blood flow by 13% and with an increase in cerebral resistance index by 7%. There was a inter-subject statistically significant relation between common carotid blood flow and index of cerebral resistances (0.78 < r < 0.98). However there was an individual reactivity with large scatter when data from different subjects were pooled. Nevertheless the results provide evidence that changes in middle cerebral artery resistance indices are reflected by common carotid blood flow modifications.

[1]  G. Greisen,et al.  Cerebral blood flow in the newborn infant: comparison of Doppler ultrasound and 133xenon clearance. , 1984, The Journal of pediatrics.

[2]  B. Lévy,et al.  Evaluation of human hemispheric blood flow based on non invasive carotid blood flow measurements using the range-gated Doppler technique. , 1982, Stroke.

[3]  Martin Reivich,et al.  ARTERIAL PCO2 AND CEREBRAL HEMODYNAMICS. , 1964 .

[4]  S. Uematsu,et al.  Measurement of carotid blood flow in man and its clinical application. , 1983, Stroke.

[5]  R. Edwards,et al.  Muscular Exercise and Fatigue , 1985, Sports medicine.

[6]  R. Aaslid,et al.  Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. , 1982, Journal of neurosurgery.

[7]  S. Quint,et al.  Enhancement of Cerebrovascular Effect of CO2 by Hypoxia , 1980, Stroke.

[8]  B. Groves,et al.  Internal carotid flow velocity with exercise before and after acclimatization to 4,300 m. , 1991, Journal of applied physiology.

[9]  A. Mark,et al.  Flow-mediated and reflex changes in large peripheral artery tone in humans. , 1989, Circulation.

[10]  E. Ringelstein,et al.  Relationship of cerebral blood flow regulation to acute mountain sickness. , 1989, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[11]  L. Wechsler,et al.  Transcranial Doppler in cerebrovascular disease. , 1986, Stroke.

[12]  O. Bailliart,et al.  Variations du débit de la carotide primitive et de ses branches lors de modifications de la composition en O2 et en CO2 du gaz alvéolaire , 1990 .

[13]  B. Pannier,et al.  Flow-dependent vasodilation of brachial artery in essential hypertension. , 1990, The American journal of physiology.

[14]  H. S. Bada,et al.  Transcutaneous Doppler ultrasound: pulsatility index, mean flow velocity, end diastolic flow velocity, and cerebral blood flow. , 1984, The Journal of pediatrics.

[15]  J. Spencer.  Use of the Vasoflo-3 for continuous-wave Doppler ultrasound measurements in pregnancy , 1989 .

[16]  O. Bailliart,et al.  Quantitative Doppler blood flow measurement method and in vivo calibration. , 1985, Cardiovascular research.

[17]  O. Bailliart,et al.  Distribution of common carotid blood flow, measured by Doppler, in man at high altitude. , 1990, Aviation, space, and environmental medicine.

[18]  D. Anderson,et al.  Autoregulation of cerebral blood flow and its relation to cerebrospinal fluid pH. , 1976, The American journal of physiology.