Moving towards efficient therapies in type 1 diabetes: to combine or not to combine?
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[1] J. Bluestone,et al. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. , 2006, The Journal of clinical investigation.
[2] Pau Serra,et al. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice , 2006, Nature Immunology.
[3] M. V. von Herrath,et al. Lost in translation , 2005, The Journal of experimental medicine.
[4] G. Nepom,et al. Targeting T Lymphocytes for Immune Monitoring and Intervention in Autoimmune Diabetes , 2005, American journal of therapeutics.
[5] B. Bisikirska,et al. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. , 2005, The Journal of clinical investigation.
[6] M. Vonherrath. E1-INT (Transition Therapeutics/Novo Nordisk). , 2005 .
[7] W. Suarez-Pinzon,et al. Combination therapy with epidermal growth factor and gastrin increases beta-cell mass and reverses hyperglycemia in diabetic NOD mice. , 2005, Diabetes.
[8] Å. Lernmark,et al. Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. , 2005, Journal of diabetes and its complications.
[9] Michel Goldman,et al. Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. , 2005, The New England journal of medicine.
[10] D. Harlan,et al. A Single Course of Anti-CD3 Monoclonal Antibody hOKT3γ1(Ala-Ala) Results in Improvement in C-Peptide Responses and Clinical Parameters for at Least 2 Years after Onset of Type 1 Diabetes , 2005, Diabetes.
[11] J. Lakey,et al. Combination therapy with epidermal growth factor and gastrin induces neogenesis of human islet {beta}-cells from pancreatic duct cells and an increase in functional {beta}-cell mass. , 2005, The Journal of clinical endocrinology and metabolism.
[12] G. Nepom,et al. Lost in translation: barriers to implementing clinical immunotherapeutics for autoimmunity , 2005 .
[13] M. V. von Herrath. E1-INT (Transition Therapeutics/Novo Nordisk). , 2005, Current opinion in investigational drugs.
[14] M. Atkinson,et al. Satisfaction (not) guaranteed: re-evaluating the use of animal models of type 1 diabetes , 2004, Nature Reviews Immunology.
[15] H. Mcdevitt,et al. Specific antigen vaccination to treat autoimmune disease , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[16] E. Bonifacio,et al. Pancreatic β-Cell Function and Immune Responses to Insulin After Administration of Intranasal Insulin to Humans At Risk for Type 1 Diabetes , 2004 .
[17] J. Habener,et al. Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4. , 2004, Diabetes.
[18] Jeffrey A. Bluestone,et al. In Vitro–expanded Antigen-specific Regulatory T Cells Suppress Autoimmune Diabetes , 2004, The Journal of experimental medicine.
[19] C. Ferran,et al. DEPLETING ANTI-CD4 MONOCLONAL ANTIBODY CURES NEW-ONSET DIABETES, PREVENTS RECURRENT AUTOIMMUNE DIABETES, AND DELAYS ALLOGRAFT REJECTION IN NONOBESE DIABETIC MICE1 , 2004, Transplantation.
[20] E. Gale. European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes , 2004, The Lancet.
[21] S. Martin,et al. Follow-up of cyclosporin A treatment in Type 1 (insulin-dependent) diabetes mellitus: lack of long-term effects , 1991, Diabetologia.
[22] E. Bonifacio,et al. Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. , 2004, Diabetes care.
[23] J. Miyazaki,et al. Systemic Administration of IL-18 Promotes Diabetes Development in Young Nonobese Diabetic Mice , 2003, The Journal of Immunology.
[24] M. Knip,et al. Intranasally administered insulin intended for prevention of type 1 diabetes—a safety study in healthy adults , 2003, Diabetes/metabolism research and reviews.
[25] J. Bluestone,et al. TGF-β-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetes , 2003, Nature Medicine.
[26] Li-he Guo,et al. Intramuscular injection of interleukin-10 plasmid DNA prevented autoimmune diabetes in mice. , 2003, Acta pharmacologica Sinica.
[27] I. Cohen,et al. T cells respond to heat shock protein 60 via TLR2: activation of adhesion and inhibition of chemokine receptors , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[28] J. Bluestone,et al. Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3γ1(Ala-Ala) , 2003 .
[29] J. Bluestone,et al. Activation of human T cells by FcR nonbinding anti-CD3 mAb, hOKT3gamma1(Ala-Ala). , 2003, The Journal of clinical investigation.
[30] P. Pozzilli. The DPT‐1 trial: a negative result with lessons for future type 1 diabetes prevention , 2002, Diabetes/metabolism research and reviews.
[31] D. Wegmann,et al. Immunological characterization and therapeutic activity of an altered-peptide ligand, NBI-6024, based on the immunodominant type 1 diabetes autoantigen insulin B-chain (9-23) peptide. , 2002, Diabetes.
[32] M. Herrath. Vaccination to prevent type 1 diabetes. , 2002 .
[33] M. V. von Herrath. Vaccination to prevent type 1 diabetes , 2002, Expert review of vaccines.
[34] S. Casares,et al. Down-regulation of diabetogenic CD4+ T cells by a soluble dimeric peptide–MHC class II chimera , 2002, Nature Immunology.
[35] L. Chatenoud,et al. Nonmitogenic CD3 Antibody Reverses Virally Induced (Rat Insulin Promoter-Lymphocytic Choriomeningitis Virus) Autoimmune Diabetes Without Impeding Viral Clearance1 , 2002, The Journal of Immunology.
[36] M. Seno,et al. Promotion of β-Cell Regeneration by Betacellulin in Ninety Percent-Pancreatectomized Rats. , 2001, Endocrinology.
[37] I. Cohen,et al. β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial , 2001, The Lancet.
[38] R. Flavell,et al. A Dual Role for TNF-α in Type 1 Diabetes: Islet-Specific Expression Abrogates the Ongoing Autoimmune Process When Induced Late but Not Early During Pathogenesis1 , 2001, The Journal of Immunology.
[39] I. Cohen,et al. Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. , 2001, Lancet.
[40] M. Seno,et al. Promotion of beta-cell regeneration by betacellulin in ninety percent-pancreatectomized rats. , 2001, Endocrinology.
[41] J. Frank,et al. Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand , 2000, Nature Medicine.
[42] A. T. N. Group,et al. No effect of oral insulin on residual beta-cell function in recent-onset Type I diabetes (the IMDIAB VII) , 2000, Diabetologia.
[43] J. Petersen,et al. Insulin in oral immune "tolerance": a one-amino acid change in the B chain makes the difference. , 1999, Journal of immunology.
[44] H. Kolb,et al. IL-18 inhibits diabetes development in nonobese diabetic mice by counterregulation of Th1-dependent destructive insulitis. , 1999, Journal of immunology.
[45] H. Kolb,et al. The Deutsche Nicotinamide Intervention Study: an attempt to prevent type 1 diabetes. DENIS Group. , 1998, Diabetes.
[46] L. Chatenoud,et al. Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic mice. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[47] T. Maki,et al. Long-term abrogation of autoimmune diabetes in nonobese diabetic mice by immunotherapy with anti-lymphocyte serum. , 1992, Proceedings of the National Academy of Sciences of the United States of America.