Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

[1]  N. Maeda,et al.  Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[2]  M. Katsuki,et al.  Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. M. J. Greevenbroek.  Lipit ve glikoz metabolizmasındaki sensörler ve anahtarlar , 1992 .

[4]  R. Krauss,et al.  Inhibition of early atherogenesis in transgenic mice by human apolipoprotein AI , 1991, Nature.

[5]  J. Hixson.  Apolipoprotein E polymorphisms affect atherosclerosis in young males. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. , 1991, Arteriosclerosis and thrombosis : a journal of vascular biology.

[6]  R. Hammer,et al.  Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors. , 1990, Science.

[7]  R. Blomhoff,et al.  Transport and storage of vitamin A , 1990, Science.

[8]  J. Breslow,et al.  Accumulation of human apolipoprotein E in the plasma of transgenic mice. , 1990, The Journal of biological chemistry.

[9]  B. Paigen,et al.  Synthetic low and high fat diets for the study of atherosclerosis in the mouse. , 1990, Journal of lipid research.

[10]  G. Schonfeld,et al.  Genetic heterogeneity of lipoproteins in inbred strains of mice: analysis by gel-permeation chromatography. , 1990, Metabolism: clinical and experimental.

[11]  R. Jaenisch,et al.  Germ-line transmission of a disrupted β2microglobulin gene produced by homologous recombination in embryonic stem cells , 1989, Nature.

[12]  K. Horiuchi,et al.  Structure and expression of mouse apolipoprotein E gene. , 1989, Journal of biochemistry.

[13]  J. Breslow,et al.  High levels of human apolipoprotein A-I in transgenic mice result in increased plasma levels of small high density lipoprotein (HDL) particles comparable to human HDL3. , 1989, The Journal of biological chemistry.

[14]  A. Joyner,et al.  Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells , 1989, Nature.

[15]  H. Mabuchi,et al.  A young type III hyperlipoproteinemic patient associated with apolipoprotein E deficiency. , 1989, Metabolism: clinical and experimental.

[16]  H. Brewer,et al.  Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[17]  Mario R. Capecchi,et al.  Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes , 1988, Nature.

[18]  J. Scott,et al.  Thyroid hormone modulates the introduction of a stop codon in rat liver apolipoprotein B messenger RNA. , 1988, The Journal of biological chemistry.

[19]  R. Mahley,et al.  Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. , 1988, Science.

[20]  C. Sing,et al.  Apolipoprotein E polymorphism and atherosclerosis. , 1988, Arteriosclerosis.

[21]  R. Williams,et al.  Quantitative assessment of atherosclerotic lesions in mice. , 1987, Atherosclerosis.

[22]  M. Capecchi,et al.  Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells , 1987, Cell.

[23]  A. Bradley.  Production and analysis of chimeric mice , 1987 .

[24]  Z W Gu,et al.  Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon. , 1987, Science.

[25]  R. Pease,et al.  A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine , 1987, Cell.

[26]  A. Lusis,et al.  Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in mice. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[27]  P. Chomczyński,et al.  Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1987, Analytical biochemistry.

[28]  M. Weintraub,et al.  Different patterns of postprandial lipoprotein metabolism in normal, type IIa, type III, and type IV hyperlipoproteinemic individuals. Effects of treatment with cholestyramine and gemfibrozil. , 1987, The Journal of clinical investigation.

[29]  M. Monk,et al.  HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells , 1987, Nature.

[30]  G. Pavlakis,et al.  The molecular basis of a familial apoE deficiency. An acceptor splice site mutation in the third intron of the deficient apoE gene. , 1987, The Journal of biological chemistry.

[31]  J. Ordovás,et al.  Familial apolipoprotein E deficiency. , 1986, The Journal of clinical investigation.

[32]  B. Paigen,et al.  Variation in susceptibility to atherosclerosis among inbred strains of mice. , 1985, Atherosclerosis.

[33]  R. Gregg,et al.  Type III Hyperlipoproteinemia: Diagnosis, Molecular Defects, Pathology, and Treatment , 1983 .

[34]  R J Havel,et al.  Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. , 1982, Journal of lipid research.

[35]  E. Schaefer,et al.  Type III hyperlipoproteinemia associated with apolipoprotein E deficiency. , 1981, Science.

[36]  J. Breslow,et al.  Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification. , 1981, Biochemistry.

[37]  K. Weber,et al.  The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. , 1969, The Journal of biological chemistry.

[38]  M. Kates,et al.  Aliphatic Diether Analogs of Glyceride-Derived Lipids. IV. The Occurrence of Di-O-dihydrophytylglycerol Ether Containing Lipids in Extremely Halophilic Bacteria* , 1966 .