Solubilisation of calcium and magnesium from the marine red algae Lithothamnion calcareum

Summary Marine minerals are a potential source of calcium and magnesium for nutritional supplementation. This study analysed the solubilisation of calcium and magnesium from the skeletal remains of Lithothamnion calcareum. Scanning electron microscopy analysis demonstrated a nonporous microstructure. Spectrophotometric determination showed that the calcium and magnesium contents were 30.01 and 6.22% (w/w), respectively. Solubilisation of calcium and magnesium was highly pH dependent. The temperature-dependent solubilisation of calcium fitted the shrinking core model. The apparent activation energy for calcium solubilisation was 28.6 kJ mol−1. Inclusion of caseinophosphopeptides (CPPs), casein-derived mineral binding peptides, during the solubilisation of calcium and magnesium appeared to decrease the extent of calcium solubilisation at pH 6.0 and 8.0. The results herein have implications for the choice of optimal pH conditions for the sustained release of calcium and magnesium from marine mineral sources.

[1]  A. Nongonierma,et al.  Biofunctional Properties of Caseinophosphopeptides in the Oral Cavity , 2012, Caries Research.

[2]  Jian-xing Ren,et al.  Dissolution rate of magnesium hydrate for wet flue gas desulfurization , 2011 .

[3]  M. Mbarawa,et al.  Dissolution rate of South African calcium-based materials at constant pH. , 2009, Journal of hazardous materials.

[4]  A. Albornoz,et al.  Porosities and pore sizes in coralline calcium carbonate , 2008 .

[5]  E. Reynolds,et al.  Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate , 2008, Journal of dental research.

[6]  M. Bedoni,et al.  Casein phosphopeptide promotion of calcium uptake in HT‐29 cells − relationship between biological activity and supramolecular structure , 2007, The FEBS journal.

[7]  S. Aydoğan,et al.  Kinetics of galena dissolution in nitric acid solutions with hydrogen peroxide , 2007 .

[8]  K. Cross,et al.  Casein phosphopeptides in oral health--chemistry and clinical applications. , 2007, Current pharmaceutical design.

[9]  R. Fitzgerald,et al.  Biofunctional peptides from milk proteins: mineral binding and cytomodulatory effects. , 2003, Current pharmaceutical design.

[10]  J. Vormann.  Magnesium: nutrition and metabolism. , 2003, Molecular aspects of medicine.

[11]  D. McCarron,et al.  Are low intakes of calcium and potassium important causes of cardiovascular disease? , 2001, American journal of hypertension.

[12]  E. Oelkers,et al.  An experimental study of calcite and limestone dissolution rates as a function of pH from −1 to 3 and temperature from 25 to 80°C , 1998 .

[13]  R. Fitzgerald.  Potential Uses of Caseinophosphopeptides , 1998 .

[14]  R. Fitzgerald,et al.  Production of caseinophosphopeptides (CPPs) from sodium caseinate using a range of commercial protease preparations , 1998 .

[15]  M. Glade.  Calcium and Related Nutrients , 1997 .

[16]  P. Metcalf,et al.  Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Atherosclerosis Risk in Communities Study. , 1995, Journal of clinical epidemiology.

[17]  E. Reynolds,et al.  Characterization of tryptic casein phosphopeptides prepared under industrially relevant conditions , 1995, Biotechnology and bioengineering.

[18]  R. T. Fowler,et al.  Micellar improvement of the calmagite compleximetric measurement of magnesium in plasma. , 1982, Clinical chemistry.

[19]  S. Cohen,et al.  Modification of the o-cresolphthalein complexone method for determining calcium. , 1979, Clinical chemistry.

[20]  W. R. Moorehead,et al.  2-Amino-2-methyl-1-propanol as the alkalizing agent in an improved continuous-flow cresolphthalein complexone procedure for calcium in serum. , 1974, Clinical chemistry.

[21]  W. Adey,et al.  Studies on the Maerl Species Phymatolithon calcareum (Pallas) nov. comb. and Lithothamnium coralloides Crouan in the Ria de Vigo , 1970 .

[22]  E. V. Mccollum,et al.  STUDIES ON MAGNESIUM DEFICIENCY IN ANIMALS III. CHEMICAL CHANGES IN THE BLOOD FOLLOWING MAGNESIUM DEPRIVATION , 1933 .