Software for the Quantification of Glistenings in Intra-Ocular Lenses

An intraocular lens (IOL) is implanted in the eye after a cataract surgery. When an IOL is in an aqueous environment, glistenings that are fluid-filled microvacuoles are often observed. Previously, studies of glistenings involved tedious work of manual glistenings labeling and rough estimation of glistening distribution. This paper proposes a software that can be used for automatic glistenings detection. The software evaluates glistenings appearance in a lens, separating the IOL lens into 3 zones and accurately computingthe average area, density and distribution to assist the user. The results are compared with clinicians hand-drawn ground truth for validation. The proposed GUI front-end is easy to use and very suitable for users who want accurate and quick glistenings detection. Numerical results can be achieved without manual drawing and rough estimation.

[1]  Asoke K. Nandi,et al.  Detection of exudates in retinal images using a pure splitting technique , 2010, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology.

[2]  Lisa Toto,et al.  Glistenings in foldable intraocular lenses , 2002, Journal of cataract and refractive surgery.

[3]  Lei Yang,et al.  A new feature-preserving nonlinear anisotropic diffusion for denoising images containing blobs and ridges , 2012, Pattern Recognit. Lett..

[4]  Luuk Franssen,et al.  Effects of glistenings in intraocular lenses. , 2013, Biomedical Optics Express.

[5]  Nahed H. Solouma,et al.  New feature-based detection of blood vessels and exudates in color fundus images , 2010, 2010 2nd International Conference on Image Processing Theory, Tools and Applications.

[6]  U. Gunenc,et al.  Effects on visual function of glistenings and folding marks in AcrySof intraocular lenses , 2001, Journal of cataract and refractive surgery.

[7]  Randall J Olson,et al.  In vitro comparison of glistening formation among hydrophobic acrylic intraocular lenses , 2002 .

[8]  Anju Vyas.  Print , 2003 .

[9]  Liang Wang,et al.  A Robust Blob Detection and Delineation Method , 2008, 2008 International Workshop on Education Technology and Training & 2008 International Workshop on Geoscience and Remote Sensing.

[10]  Liliana Werner,et al.  Glistenings and surface light scattering in intraocular lenses , 2010, Journal of cataract and refractive surgery.

[11]  David Touboul,et al.  Incidence of glistenings with the latest generation of yellow‐tinted hydrophobic acrylic intraocular lenses , 2012, Journal of cataract and refractive surgery.

[12]  Akira Hirata,et al.  Long-term effect of surface light scattering and glistenings of intraocular lenses on visual function. , 2012, American journal of ophthalmology.

[13]  Yasuhiko Shiokawa,et al.  Influence of glistenings on the optical quality of acrylic foldable intraocular lens , 2001, The British journal of ophthalmology.

[14]  David Touboul,et al.  Glistenings in a large series of hydrophobic acrylic intraocular lenses , 2009, Journal of cataract and refractive surgery.

[15]  Roberto Bellucci,et al.  An Introduction to Intraocular Lenses: Material, Optics, Haptics, Design and Aberration , 2013 .

[16]  Anders Behndig,et al.  Impact on visual function from light scattering and glistenings in intraocular lenses, a long‐term study , 2011, Acta ophthalmologica.

[17]  Nick Mamalis.  Intraocular lens glistenings. , 2012, Journal of cataract and refractive surgery.

[18]  Joseph Colin,et al.  Glistenings on intraocular lenses in healthy eyes: effects and associations. , 2011, Journal of refractive surgery.

[19]  K. Nakamae,et al.  Glistening formation in an AcrySof lens initiated by spinodal decompositionof the polymer network bytemperature change , 2001, Journal of cataract and refractive surgery.