Corneal confocal microscopy reveals small nerve fibre loss correlating with motor function in adult spinal muscular atrophy

5q Spinal muscular atrophy (SMA) is a progressive, inherited, and severely disabling – yet treatable – motor neuron disease. Although treatment options have evolved in recent years, biomarkers for treatment monitoring and prognosis prediction remain elusive. Here, we investigated the utility of corneal confocal microscopy (CCM), a non‐invasive imaging technique to quantify small corneal nerve fibres in vivo, as a diagnostic tool in adult SMA.

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