Effect of furosemide on urinary kallikrein excretion in patients with essential hypertension.

The effect of furosemide on urinary kallikrein excretion was studied in 10 patients with essential hypertension and 9 normal volunteer subjects. After intravenous administration of furosemide and 2 hours of upright posture, urine volume (UV), urinary sodium (UNaV) and potassium (UKV) excretion, plasma renin activity (PRA), plasma aldosterone concentration (PAC) and urinary kallikrein markedly increased. However, the augmentation of urinary kallikrein in patients with essential hypertension (1.50 +/- 0.19 EU/2 hr) was less remarkable than that in normal subjects (2.33 +/- 0.24 EU/2 hr), although the same degrees of response were observed in PRA and PAC. The increments of UV, UNaV and UKV in patients with essential hypertension were also significantly lower than in normal subjects. Significant positive relations were found between urinary kallikrein and UV or UNaV in both hypertensive and normotensive groups, but there was no such correlation before fursemide administration. It is likely that diuresis and natriuresis induced by furosemide are somehow associated with an increase in urinary kallikrein excretion. Blunted response of urinary kallikrein in essential hypertension may suggest an abnormality in the renal kallikrein-kinin system in this disease.

[1]  U. B. Olsen,et al.  Bumetanide induced increase of renal blood flow in conscious dogs and its relation to local renal hormones (PGE, kallikrein and renin). , 2009, Acta pharmacologica et toxicologica.

[2]  M. Yasujima,et al.  Effect of spironolactone on urinary kallikrein excretion in patients with essential hypertension and in primary aldosteronism. , 1977, The Tohoku journal of experimental medicine.

[3]  E. De Vito,et al.  Kallikreinlike activity in perfusates and urine of isolated rat kidneys. , 1976, The American journal of physiology.

[4]  Y. Fujimoto,et al.  Fluorometric method for assay of kallikrein-like arginine esterases. , 1976, Journal of biochemistry.

[5]  G. Bianchi,et al.  Urinary Kallikrein Excretion in a Spontaneously Hypertensive Strain of Rats , 1975, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[6]  Y. Otsuka,et al.  Urinary kallikrein excretion and sodium metabolism in hypertensive patients. , 1975, The Tohoku journal of experimental medicine.

[7]  M. Yasujima,et al.  Circulating renin in essential hypertension: an evaluation of its significance in the Japanese population. , 1975, American heart journal.

[8]  H. Margolius,et al.  Urinary Kallikrein Excretion in Spontaneously Hypertensive Rats , 1975, Circulation research.

[9]  I. Mills,et al.  The relationship between kallikrein and water excretion and the conditional relationship between kallikrein and sodium excretion. , 1975, The Journal of physiology.

[10]  R. Colman,et al.  Response of the kallikrein-kinin and renin-angiotensin systems to saline infusion and upright posture. , 1975, The Journal of clinical investigation.

[11]  K. Nustad,et al.  SYNTHESIS OF KALLIKREINS BY RAT KIDNEY SLICES , 1975, British journal of pharmacology.

[12]  H. Margolius,et al.  Urinary Kallikrein Excretion in Hypertensive Man: Relationships to Sodium intake and Sodium‐Retaining Steroids , 1974, Circulation research.

[13]  R. Alexander,et al.  Urinary Kallikrein Excretion in Normal Man: Relationships to Sodium Intake and Sodium‐Retaining Steroids , 1974, Circulation research.

[14]  O. Carretero,et al.  Evidence for an involvement of kinins in regulation of sodium excretion. , 1972, The American journal of physiology.

[15]  T. Saito,et al.  [Measurement of plasma renin activity by angiotensin I radioimmunoassay--a modification of Haber's method]. , 1972, Japanese circulation journal.

[16]  I. Mills,et al.  Relation between urinary kallikrein and renal function, hypertension, and excretion of sodium and water in man. , 1972, Lancet.

[17]  A. Sjoerdsma,et al.  Altered urinary kallikrein excretion in human hypertension. , 1971, Lancet.

[18]  K. Nustad.  The relationship between kidney and urinary kininogenase , 1970, British journal of pharmacology.

[19]  B. Wajchenberg,et al.  The site of action of furosemide in the human kidney , 1967 .

[20]  W. Suki,et al.  THE SITE OF ACTION OF FUROSEMIDE AND OTHER SULFONAMIDE DIURETICS IN THE DOG. , 1965, The Journal of clinical investigation.

[21]  C. Johnston,et al.  Renin-angiotensin and kallikrein-kinin systems in sodium homeostasis and hypertension in rats. , 1976, Clinical science and molecular medicine. Supplement.