Flexible, electrostatic microfluidic actuators based on thin film fabrication

Abstract Active microfluidic components are required in many lab-on-a-chip applications, for handling tiny amounts of liquids on the platform. The work presented here reveals an electrostatic microfluidic actuators that can be fabricated with thin film process technology, and is based on flexible, biocompatible materials. We have successfully characterized microvalves for both the static and dynamic mode, using non-polar fluids. An extension of the proposed fabrication method enables actuation of fluids of any polarity, as the electrostatic field no longer crosses the transport fluid

[1]  S. Quake,et al.  Monolithic microfabricated valves and pumps by multilayer soft lithography. , 2000, Science.

[2]  Bruce K. Gale,et al.  A PDMS-based gas permeation pump for on-chip fluid handling in microfluidic devices , 2006 .

[3]  P. Renaud,et al.  Polyimide-based microfluidic devices. , 2001, Lab on a Chip.

[4]  Urban Simu,et al.  A polymeric paraffin actuated high-pressure micropump , 2006 .

[5]  Alan G. R. Evans,et al.  Novel actuation of an integrated peristaltic micropump , 2004 .

[6]  M. C. Tracey,et al.  Dual independent displacement-amplified micropumps with a single actuator , 2006 .

[7]  C. Cabuz,et al.  The dual diaphragm pump , 2001, Technical Digest. MEMS 2001. 14th IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.01CH37090).

[8]  Mihail Patrascu Characterization, modeling and control of the [mu]walker, - a micro actuator for data storage - , 2006 .

[9]  Alan G. R. Evans,et al.  Investigation for the operation of an integrated peristaltic micropump , 2004 .

[10]  Wataru Satoh,et al.  Biochip with integrated pumps for plug-based sequential exchange of solutions , 2009 .

[11]  Hidetoshi Kotera,et al.  Concepts for a new class of all-polymer micropumps. , 2006, Lab on a chip.

[12]  Ark-Chew Wong,et al.  VHF free-free beam high-Q micromechanical resonators , 2000, Journal of Microelectromechanical Systems.

[13]  Onnop Srivannavit,et al.  A versatile microreactor platform featuring a chemical-resistant microvalve array for addressable multiplex syntheses and assays , 2006 .

[14]  G. Whitesides The origins and the future of microfluidics , 2006, Nature.

[15]  Roland Zengerle,et al.  Centrifugo-magnetic pump for gas-to-liquid sampling , 2007 .

[16]  Srinivas Tadigadapa,et al.  Electroactive polymer based microfluidic pump , 2006 .

[17]  P. Renaud,et al.  Partial release and detachment of microfabricated metal and polymer structures by anodic metal dissolution , 2005, Journal of Microelectromechanical Systems.

[18]  Nicholas A Peppas,et al.  Microfabricated drug delivery devices. , 2005, International journal of pharmaceutics.

[19]  R. Engelbrecht,et al.  DIGEST of TECHNICAL PAPERS , 1959 .

[20]  Jan Lichtenberg,et al.  Thermo-pneumatic, single-stroke micropump , 2005 .

[21]  Christopher D. Batich,et al.  Fabrication and testing of a magnetically actuated micropump , 2002 .

[22]  Asim Nisar,et al.  MEMS-based micropumps in drug delivery and biomedical applications , 2008 .

[23]  Chong H. Ahn,et al.  Institute of Physics Publishing Journal of Micromechanics and Microengineering a Review of Microvalves , 2022 .

[24]  K. Najafi,et al.  A fully integrated high-efficiency peristaltic 18-stage gas micropump with active microvalves , 2007, 2007 IEEE 20th International Conference on Micro Electro Mechanical Systems (MEMS).

[25]  Juan G. Santiago,et al.  A review of micropumps , 2004 .

[26]  Design, fabrication, and test of a peristaltic micropump , 2004 .

[27]  Robert Langer,et al.  Application of Micro- and Nano-Electromechanical Devices to Drug Delivery , 2006, Pharmaceutical Research.

[28]  Nan-Chyuan Tsai,et al.  Review of MEMS-based drug delivery and dosing systems , 2007 .

[29]  H. Kawada,et al.  Thermally driven microactuator containing thermal isolation structure with polyimide and its application to microvalve , 2003, TRANSDUCERS '03. 12th International Conference on Solid-State Sensors, Actuators and Microsystems. Digest of Technical Papers (Cat. No.03TH8664).

[30]  Stefano Stramigioli,et al.  An energy-based electroelastic beam model for MEMS applications , 2005 .

[31]  E. S. Kim,et al.  Micropump based on PZT unimorph and one-way parylene valves , 2004 .

[32]  Jishan Hu,et al.  A study of the performance of microfabricated electroosmotic pump , 2007 .

[33]  Mir Majid Teymoori,et al.  Design and simulation of a novel electrostatic peristaltic micromachined pump for drug delivery applications , 2005 .

[34]  Hanseup Kim,et al.  Analysis and Design of Multistage Electrostatically-Actuated Micro Vacuum Pumps , 2002 .

[35]  Vincent T. Remcho,et al.  PDMS and tubing-based peristaltic micropumps with direct actuation , 2009 .

[36]  Hiroyuki Fujita,et al.  On-chip syringe pumps for picoliter-scale liquid manipulation. , 2006, Lab on a chip.

[37]  P. Woias,et al.  Pressure-Independent Micropump with Piezoelectric Valves for Low Flow Drug Delivery Systems , 2006, 19th IEEE International Conference on Micro Electro Mechanical Systems.

[38]  Chih-Ming Ho,et al.  Conductive silicone based MEMS sensor and actuator , 2005, The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05..

[39]  M. M. Piñeiro,et al.  Relative permittivities of binary mixtures of 1-butanol + n-alkane AT 298.15 k , 2003 .

[40]  J. Eijkel,et al.  1-D nanochannels fabricated in polyimide. , 2004, Lab on a chip.

[41]  Micah Yairi,et al.  Massively parallel microfluidic pump , 2007 .

[42]  Chia-Yen Lee,et al.  Valveless impedance micropump with integrated magnetic diaphragm , 2010, Biomedical microdevices.

[43]  K. West,et al.  An all-polymer micropump based on the conductive polymer poly(3,4-ethylenedioxythiophene) and a polyurethane channel system , 2007 .

[44]  Mihai Patrascu,et al.  Novel Approach for Physical Modeling of Microfluidic Systems , 2007 .

[45]  T. Bourouina,et al.  Design and simulation of an electrostatic micropump for drug-delivery applications , 1997 .

[46]  Jun Xie,et al.  Surface micromachined electrostatically actuated micro peristaltic pump. , 2004, Lab on a chip.

[47]  Andrés J. García,et al.  SU-8 2000 rendered cytocompatible for neuronal bioMEMS applications. , 2008, Journal of biomedical materials research. Part A.

[48]  K. Najafi,et al.  A Micropump-Driven High-Speed MEMS Gas Chromatography System , 2007, TRANSDUCERS 2007 - 2007 International Solid-State Sensors, Actuators and Microsystems Conference.

[49]  Sehwan Lee,et al.  Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters. , 2008, Lab on a chip.

[50]  Werner Karl Schomburg,et al.  An electrostatically actuated polymer microvalve equipped with a movable membrane electrode , 1997 .

[51]  Bumkyoo Choi,et al.  A study on the development of a continuous peristaltic micropump using magnetic fluids , 2006 .

[52]  Satoshi Konishi,et al.  Fabrication of a peristaltic micro pump with novel cascaded actuators , 2008 .

[53]  Yael Nemirovsky,et al.  A membrane micropump electrostatically actuated across the working fluid , 2005 .

[54]  Thomas W. Kenny,et al.  A Micromachined Silicon Low-Voltage Parallel-Plate Electrokinetic Pump , 2001 .