Pyoderma Gangrenosum: A Rare Disease with Dire Consequences in Facial Aesthetic Surgery Patients.

Pyoderma gangrenosum (PG) is a rare, inflammatory dermatologic condition characterized by painful cutaneous ulcerations. Herein, we describe the third documented case of PG arising in an elective plastic surgery patient who had undergone an otherwise uncomplicated facelift. We describe the course of her diagnosis and management of PG involving her face and neck and then progressing to her lower extremities. Although the etiology remains unknown, PG often arises in a host with another autoimmune disease. In the case described, the patient was diagnosed with an IgA gammopathy shortly after development of PG. Following the case report, the pathogenesis, diagnosis and treatment strategy of PG is briefly reviewed.

[1]  M. Pichler,et al.  Surgical treatment of pyoderma gangrenosum with negative pressure wound therapy and skin grafting, including xenografts - personal experience and comprehensive review on 161 cases. , 2020, Advances in wound care.

[2]  Lifei Guo,et al.  A Deceptive Diagnosis: Pyoderma Gangrenosum After Breast Surgery-A Case Series and Literature Review. , 2019, Annals of plastic surgery.

[3]  J. Niamtu Pyoderma Gangrenosum After Facelift and Otoplasty Surgery: Case Presentations and Literature Review. , 2019, Journal of oral and maxillofacial surgery.

[4]  S. Benson,et al.  The PARACELSUS score: a novel diagnostic tool for pyoderma gangrenosum , 2019, The British journal of dermatology.

[5]  J. Satpathy,et al.  Pyoderma gangrenosum misdiagnosis resulting in amputation: A review , 2019, The journal of trauma and acute care surgery.

[6]  Rosie Qin,et al.  Diagnostic Criteria of Ulcerative Pyoderma Gangrenosum: A Delphi Consensus of International Experts , 2018, JAMA dermatology.

[7]  R. Andreini,et al.  Pyoderma Gangrenosum: A Current Problem as Much as an Unknown One , 2017, The international journal of lower extremity wounds.

[8]  V. Shanmugam,et al.  Vasculitic and autoimmune wounds. , 2017, Journal of vascular surgery. Venous and lymphatic disorders.

[9]  S. Cha,et al.  Postoperative Pyoderma Gangrenosum: A Clinical Review of Published Cases. , 2016, Mayo Clinic proceedings.

[10]  A. Ortega‐Loayza,et al.  Pathophysiology of pyoderma gangrenosum (PG): an updated review. , 2015, Journal of the American Academy of Dermatology.

[11]  M. Camilleri,et al.  Postoperative pyoderma gangrenosum (PG): the Mayo Clinic experience of 20 years from 1994 through 2014. , 2015, Journal of the American Academy of Dermatology.

[12]  S. Feldman,et al.  The genetics of pyoderma gangrenosum and implications for treatment: a systematic review , 2015, The British journal of dermatology.

[13]  K. Zuo,et al.  A systematic review of post-surgical pyoderma gangrenosum: identification of risk factors and proposed management strategy. , 2015, Journal of plastic, reconstructive & aesthetic surgery : JPRAS.

[14]  E. Doren,et al.  Pyoderma gangrenosum following breast reduction: treatment with topical tacrolimus and steroids. , 2014, Aesthetic surgery journal.

[15]  K. Shinkai,et al.  Etiology and Management of Pyoderma Gangrenosum , 2012, American Journal of Clinical Dermatology.

[16]  D. Fanoni,et al.  Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil‐mediated skin diseases , 2010, Clinical and experimental immunology.

[17]  Parviz Goshtasby,et al.  A novel approach to the management of pyoderma gangrenosum complicating reduction mammaplasty. , 2010, Aesthetic surgery journal.

[18]  J. Man,et al.  Pyoderma Gangrenosum: Common Pitfalls in Management and a Stepwise, Evidence-Based, Therapeutic Approach , 2009, Journal of cutaneous medicine and surgery.

[19]  J. Callen,et al.  Pyoderma gangrenosum: an update. , 2007, Rheumatic diseases clinics of North America.

[20]  U. Wollina Pyoderma gangrenosum – a review , 2007, Orphanet journal of rare diseases.

[21]  J. Berthe,et al.  Post-surgical Pyoderma Gangrenosum: a Clinical Entity , 2007, Acta chirurgica Belgica.

[22]  D. Sharpe,et al.  Bilateral pyoderma gangrenosum complicating minimal access cranial suspension face lift. , 2006, Aesthetic surgery journal.

[23]  S. Mcneill,et al.  Prostatic infarction involving the urinary sphincter, an association with pyoderma gangrenosum. , 2006, European urology.

[24]  J. Niezgoda,et al.  Managing pyoderma gangrenosum: a synergistic approach combining surgical débridement, vacuum-assisted closure, and hyperbaric oxygen therapy. , 2006, Plastic and reconstructive surgery.

[25]  R. Weenig,et al.  Pyoderma gangrenosum: clinicopathologic correlation and proposed diagnostic criteria , 2004, International journal of dermatology.

[26]  F. Klebl,et al.  Therapeutic management of pyoderma gangrenosum. , 2004, Arthritis and rheumatism.

[27]  P. R. Dahl,et al.  Skin ulcers misdiagnosed as pyoderma gangrenosum. , 2002, The New England journal of medicine.

[28]  A. Fleischer,et al.  Pyoderma Gangrenosum A Comparison of Typical and Atypical Forms with an Emphasis on Time to Remission. Case Review of 86 Patients from 2 Institutions , 2000, Medicine.

[29]  H. Petty,et al.  Aberrant neutrophil trafficking and metabolic oscillations in severe pyoderma gangrenosum. , 1998, The Journal of investigative dermatology.

[30]  P. Driesch,et al.  Pyoderma gangrenosum: a report of 44 cases with follow‐up , 1997, The British journal of dermatology.

[31]  W. Su,et al.  Pyoderma gangrenosum: classification and management. , 1996, Journal of the American Academy of Dermatology.

[32]  J. G. Hickman Pyoderma gangrenosum. , 1983, Clinics in dermatology.