'Am not I a fly like thee?' From genes in fruit flies to behavior in humans.

The fruit fly Drosophila melanogaster has provided insight into the role of genes in behavior, some of which have relevant implications for humans. Mutants induced or engineered in the laboratory have contributed to our understanding of biological rhythms, learning, memory, neurodegenerative disease and drug response. Studies of naturally occurring genetic variation in behavior have advanced our understanding of what kinds of variants arise spontaneously and contribute to behavior.

[1]  J. Takahashi,et al.  Mammalian circadian biology: elucidating genome-wide levels of temporal organization. , 2004, Annual review of genomics and human genetics.

[2]  R. Greenspan E pluribus unum, ex uno plura: quantitative and single-gene perspectives on the study of behavior. , 2004, Annual review of neuroscience.

[3]  Francesco Scaravilli,et al.  Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease , 2004, Nature Genetics.

[4]  D. Nanopoulos,et al.  Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons. , 2004, Learning & memory.

[5]  Ann-Shyn Chiang,et al.  Dissecting the pathological effects of human Aβ40 and Aβ42 in Drosophila: A potential model for Alzheimer's disease , 2004 .

[6]  Gyeong-Moon Kim,et al.  Expression of Expanded Polyglutamine Protein Induces Behavioral Changes in Drosophila (Polyglutamine-Induced Changes in Drosophila) , 2004, Cellular and Molecular Neurobiology.

[7]  J. Shulman,et al.  Genetic modifiers of tauopathy in Drosophila. , 2003, Genetics.

[8]  T. Tully,et al.  A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[9]  W. Weiner,et al.  From fruit fly to bedside: translating lessons from Drosophila models of neurodegenerative disease , 2003, Current opinion in neurology.

[10]  V. Lee,et al.  Are Ubiquitination Pathways Central to Parkinson's Disease? , 2003, Cell.

[11]  Josephine Arendt,et al.  A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. , 2003, Sleep.

[12]  Beate Gerstbrein,et al.  Dying for a cause: invertebrate genetics takes on human neurodegeneration , 2003, Nature Reviews Genetics.

[13]  Jeffrey C. Hall,et al.  Genetics and molecular biology of rhythms in Drosophila and other insects. , 2003, Advances in genetics.

[14]  Ann-Shyn Chiang,et al.  The staufen/pumilio Pathway Is Involved in Drosophila Long-Term Memory , 2003, Current Biology.

[15]  J. Dubnau NEUROGENETIC DISSECTION OF CONDITIONED BEHAVIOR: EVOLUTION BY ANALOGY OR HOMOLOGY? , 2003, Journal of neurogenetics.

[16]  W. Schafer Genetic analysis of nicotinic signaling in worms and flies. , 2002, Journal of neurobiology.

[17]  H. Zoghbi,et al.  Mouse and fly models of neurodegeneration. , 2002, Trends in genetics : TIG.

[18]  M. Ritchie,et al.  Quantitative trait loci affecting a courtship signal in Drosophila melanogaster , 2002, Heredity.

[19]  K. White,et al.  Identification of genes involved in Drosophila melanogaster geotaxis, a complex behavioral trait , 2002, Nature Genetics.

[20]  M Gribskov,et al.  A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. , 2001, Genome research.

[21]  Yuichi Inoue,et al.  Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome , 2001, EMBO reports.

[22]  Giulio Tononi,et al.  Sleep and the fruit fly , 2001, Trends in Neurosciences.

[23]  Christopher R. Jones,et al.  An hPer2 Phosphorylation Site Mutation in Familial Advanced Sleep Phase Syndrome , 2001, Science.

[24]  M. Boguski,et al.  A Survey of Human Disease Gene Counterparts in the Drosophila Genome , 2000, The Journal of cell biology.

[25]  R. Hennekam,et al.  Rubinstein-Taybi syndrome caused by a De Novo reciprocal translocation t(2;16)(q36.3;p13.3). , 2000, American journal of medical genetics.

[26]  M. R. Adams,et al.  Comparative genomics of the eukaryotes. , 2000, Science.

[27]  J. Hirsh,et al.  Ectopic G-protein expression in dopamine and serotonin neurons blocks cocaine sensitization in Drosophila melanogaster , 2000, Current Biology.

[28]  J. Hirsh,et al.  The trace amine tyramine is essential for sensitization to cocaine in Drosophila , 1999, Current Biology.

[29]  J. Hirsh,et al.  Requirement of circadian genes for cocaine sensitization in Drosophila. , 1999, Science.

[30]  K. White,et al.  Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport , 1999, Current Biology.

[31]  Jay Hirsh,et al.  Stereotypic behavioral responses to free-base cocaine and the development of behavioral sensitization in Drosophila , 1998, Current Biology.

[32]  W. Quinn,et al.  A neuropeptide gene defined by the Drosophila memory mutant amnesiac. , 1995, Science.

[33]  T. Tully,et al.  Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for appl gene , 1992, Neuron.

[34]  C P Kyriacou,et al.  Circadian rhythm mutations in Drosophila melanogaster affect short-term fluctuations in the male's courtship song. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Y. Jan,et al.  dunce, a mutant of Drosophila deficient in learning. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[36]  R J Konopka,et al.  Clock mutants of Drosophila melanogaster. , 1971, Proceedings of the National Academy of Sciences of the United States of America.

[37]  U. Heberlein,et al.  Invertebrate models of drug abuse. , 2003, Journal of neurobiology.

[38]  R. Pendleton,et al.  Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster. , 2002, The Journal of pharmacology and experimental therapeutics.

[39]  Michael Gribskov,et al.  Homophila: human disease gene cognates in Drosophila , 2002, Nucleic Acids Res..

[40]  B. Tabakoff,et al.  Animal Models in Alcohol Research , 2000, Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism.

[41]  M. W. Young The molecular control of circadian behavioral rhythms and their entrainment in Drosophila. , 1998, Annual review of biochemistry.

[42]  J. Hirsch,et al.  Genetic changes occurring over 500 generations in lines ofDrosophila melanogaster selected divergently for geotaxis , 1988, Behavior genetics.