Analyzed are the data on epizootiological and epidemiological surveillance of tularemia foci, situated in the territory of 85 constituent entities of the Russian Federation. Positive findings, obtained in the process of examination of small mammals, Ixodidae ticks, mosquitoes, and environmental objects, using immunological and molecular-genetic methods; isolated tularemia agent cultures; as well as tularemia incidence rates among the population have made provisions for the assessment of circulation and infection activity in the Regions. In period of 2015, 71 cases of human infection with tularemia have been registered. Given is a brief characteristics of activity of the natural tularemia foci and epidemic situation in the territory of the Russian Federation in 2015. Specified are the regions where preventive vaccination is on a low level. Given is the differentiation of RF territories according to the risk of exposure to tularemia infection for 2016.