Metabolic Alterations Caused by Simultaneous Loss of HK2 and PKM2 Leads to Photoreceptor Dysfunction and Degeneration
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E. Weh | S. Chaudhury | M. Goswami | R. Fernando | C. Besirli | Sarah Sheskey | T. Wubben | Heather M. Hager | H. Hager | Nick Miller | Vikram Sharma | Eric Weh
[1] E. Weh,et al. Flow cytometric method for the detection and quantification of retinal cell death and oxidative stress. , 2023, Experimental eye research.
[2] J. Stuckey,et al. Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis , 2023, Pharmaceuticals.
[3] Merve Kulbay,et al. Retinitis Pigmentosa: Novel Therapeutic Targets and Drug Development , 2023, Pharmaceutics.
[4] K. Xue,et al. Gene-agnostic therapeutic approaches for inherited retinal degenerations , 2023, Frontiers in Molecular Neuroscience.
[5] H. Klassen,et al. Potential therapeutic strategies for photoreceptor degeneration: the path to restore vision , 2022, Journal of Translational Medicine.
[6] R. Casson,et al. Investigations into photoreceptor energy metabolism during experimental retinal detachment , 2022, Frontiers in Cellular Neuroscience.
[7] M. Romano,et al. Genetic Aspects of Age-Related Macular Degeneration and Their Therapeutic Potential , 2022, International journal of molecular sciences.
[8] E. Weh,et al. Dark-reared rd10 mice experience rapid photoreceptor degeneration with short exposure to room-light during in vivo retinal imaging. , 2021, Experimental eye research.
[9] Marcel T. Bernucci,et al. Cone photoreceptor dysfunction in retinitis pigmentosa revealed by optoretinography , 2021, Proceedings of the National Academy of Sciences.
[10] Katherine J. Wert,et al. Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa , 2021, JCI insight.
[11] R. Ciuluvică,et al. NAD+ metabolism and retinal degeneration (Review). , 2021, Experimental and therapeutic medicine.
[12] J. Hurley. Retina Metabolism and Metabolism in the Pigmented Epithelium: A Busy Intersection. , 2021, Annual review of vision science.
[13] C. Besirli,et al. Photoreceptor metabolic reprogramming: current understanding and therapeutic implications , 2021, Communications Biology.
[14] J. Baur,et al. Role of NAD+ in regulating cellular and metabolic signaling pathways , 2021, Molecular metabolism.
[15] M. Gillies,et al. Selective knockdown of hexokinase 2 in rods leads to age-related photoreceptor degeneration and retinal metabolic remodeling , 2020, Cell Death & Disease.
[16] Fay G. Newton,et al. Mechanisms of Photoreceptor Death in Retinitis Pigmentosa , 2020, Genes.
[17] C. Punzo,et al. Altered photoreceptor metabolism in mouse causes late stage age-related macular degeneration-like pathologies , 2020, Proceedings of the National Academy of Sciences.
[18] Ashish,et al. Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis , 2020, Frontiers in Oncology.
[19] C. Lyssiotis,et al. Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis , 2020, Scientific Reports.
[20] E. Weh,et al. Hexokinase 2 is dispensable for photoreceptor development but is required for survival during aging and outer retinal stress , 2019, Cell Death & Disease.
[21] Ho-Joon Lee,et al. A large-scale analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics , 2019, Metabolomics.
[22] J. Asara,et al. Ex vivo and in vivo stable isotope labelling of central carbon metabolism and related pathways with analysis by LC–MS/MS , 2019, Nature Protocols.
[23] Ho-Joon Lee,et al. Meta-analysis of targeted metabolomics data from heterogeneous biological samples provides insights into metabolite dynamics , 2019, bioRxiv.
[24] Ho-Joon Lee,et al. Macrophage Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer , 2018, bioRxiv.
[25] J. Sahel,et al. Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps , 2018, Translational vision science & technology.
[26] Machelle T. Pardue,et al. Neuroprotective strategies for retinal disease , 2018, Progress in Retinal and Eye Research.
[27] C. Punzo,et al. Aerobic Glycolysis Is Essential for Normal Rod Function and Controls Secondary Cone Death in Retinitis Pigmentosa , 2018, Cell reports.
[28] J. Linton,et al. Pyruvate kinase M2 regulates photoreceptor structure, function, and viability , 2018, Cell Death & Disease.
[29] Mercy D Pawar,et al. Photoreceptor metabolic reprogramming provides survival advantage in acute stress while causing chronic degeneration , 2017, Scientific Reports.
[30] J. Linton,et al. Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye , 2017, bioRxiv.
[31] C. Cepko,et al. Glycolytic reliance promotes anabolism in photoreceptors , 2017, bioRxiv.
[32] Yuhong Wang,et al. The Warburg Effect Mediator Pyruvate Kinase M2 Expression and Regulation in the Retina , 2016, Scientific Reports.
[33] H. Kaplan,et al. Two-Step Reactivation of Dormant Cones in Retinitis Pigmentosa. , 2016, Cell reports.
[34] M. Ye,et al. Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1 , 2016, Scientific Reports.
[35] S. Tsang,et al. Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina* , 2015, The Journal of Biological Chemistry.
[36] R. Deberardinis,et al. PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth. , 2015, Molecular cell.
[37] J. Hurley,et al. Glucose, lactate, and shuttling of metabolites in vertebrate retinas , 2015, Journal of neuroscience research.
[38] D. Peet,et al. Cancer‐like metabolism of the mammalian retina , 2015, Clinical & experimental ophthalmology.
[39] C. Punzo,et al. Activated mTORC1 promotes long-term cone survival in retinitis pigmentosa mice. , 2015, The Journal of clinical investigation.
[40] Judy Yan,et al. PKM2 contributes to cancer metabolism. , 2015, Cancer letters.
[41] F. Fitzke,et al. Visual Psychophysics and Physiological Optics Dark-Adaptation Functions in Molecularly Confirmed Achromatopsia and the Implications for Assessment in Retinal Therapy Trials , 2014 .
[42] D. Zacks,et al. Retinal cell death and current strategies in retinal neuroprotection , 2014, Current opinion in ophthalmology.
[43] S. Miyamoto,et al. Hexokinase-II positively regulates glucose starvation-induced autophagy through TORC1 inhibition. , 2014, Molecular cell.
[44] Edan Foley,et al. Hexokinase 1 blocks apoptotic signals at the mitochondria. , 2013, Cellular signalling.
[45] R. Casson,et al. An explanation for the Warburg effect in the adult mammalian retina , 2013, Clinical & experimental ophthalmology.
[46] J. Asara,et al. A positive/negative ion–switching, targeted mass spectrometry–based metabolomics platform for bodily fluids, cells, and fresh and fixed tissue , 2012, Nature Protocols.
[47] J. Linton,et al. Roles of Glucose in Photoreceptor Survival* , 2011, The Journal of Biological Chemistry.
[48] Zhiyong Wang,et al. Hexokinase regulates Bax-mediated mitochondrial membrane injury following ischemic stress. , 2011, Kidney international.
[49] Joydeep Mukherjee,et al. Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme , 2011, The Journal of experimental medicine.
[50] V. Shoshan-Barmatz,et al. Key regions of VDAC1 functioning in apoptosis induction and regulation by hexokinase. , 2009, Biochimica et biophysica acta.
[51] Gordon L. Fain,et al. ATP Consumption by Mammalian Rod Photoreceptors in Darkness and in Light , 2008, Current Biology.
[52] V. Shoshan-Barmatz,et al. Hexokinase-I Protection against Apoptotic Cell Death Is Mediated via Interaction with the Voltage-dependent Anion Channel-1 , 2008, Journal of Biological Chemistry.
[53] R. Barlow,et al. Hypoglycemia leads to age-related loss of vision , 2006, Proceedings of the National Academy of Sciences.
[54] Y. Le,et al. Mouse opsin promoter-directed Cre recombinase expression in transgenic mice. , 2006, Molecular vision.
[55] A. Vaag,et al. Effect of short-term hyperglycemia on multifocal electroretinogram in diabetic patients without retinopathy. , 2004, Investigative ophthalmology & visual science.
[56] A. Vingrys,et al. The contribution of glycolytic and oxidative pathways to retinal photoreceptor function. , 2003, Investigative ophthalmology & visual science.
[57] J. Hoek,et al. Mitochondrial Binding of Hexokinase II Inhibits Bax-induced Cytochrome c Release and Apoptosis* , 2002, The Journal of Biological Chemistry.
[58] M. T. Davisson,et al. Retinal degeneration mutants in the mouse , 2002, Vision Research.
[59] N. Peachey,et al. Age-Related Changes in the Mouse Outer Retina , 2001, Optometry and vision science : official publication of the American Academy of Optometry.
[60] A. Bill,et al. Glucose metabolism in pig outer retina in light and darkness. , 1997, Acta physiologica Scandinavica.
[61] C. Macaluso,et al. Changes in glucose level affect rod function more than cone function in the isolated, perfused cat eye. , 1992, Investigative ophthalmology & visual science.
[62] B. S. Winkler. Glycolytic and oxidative metabolism in relation to retinal function , 1981, The Journal of general physiology.
[63] B. S. Winkler,et al. The electroretinogram of the isolated rat retina. , 1972, Vision research.
[64] Angela Y. Chang. Challenges of Treatment Methodologies and the Future of Gene Therapy and Stem Cell Therapy to Treat Retinitis Pigmentosa. , 2023, Methods in molecular biology.
[65] A. Goldberg,et al. Photoreceptor renewal: a role for peripherin/rds. , 2002, International review of cytology.