Extracellular Matrix and Growth Factors During Heart Growth

The effects of growth factors on tissue remodeling and cell differentiation depend on the nature of the extracellular matrix, the type and organization of integrins, the activation of metalloproteinases and the presence of secreted proteins associated to the matrix. These interactions are actually poorly known in the cardiovascular system. We describe here: 1) the main components of extracellular matrix within the cardiovascular system; 2) the role of integrins in the transmission of growth signals; 3) the shift in the expression of the components of the extracellular matrix (fibronectin and collagens) and the stimulation of the synthesis of metalloproteinases during normal and hypertrophic growth of the myocardium; 4) the effects of growth factors, such as Angiotensin II, Fibroblast Growth Factors (FGF), Transforming Growth Factor-β (TGF-β), on the synthesis of proteins of the extracellular matrix in the heart.

[1]  A. Chobanian,et al.  Angiotensin II induces fibronectin expression associated with cardiac fibrosis in the rat. , 1994, Circulation research.

[2]  E. J. Brown,et al.  Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators. , 1992, The New England journal of medicine.

[3]  P. Jones,et al.  Regulation of Tenascin-C, a Vascular Smooth Muscle Cell Survival Factor that Interacts with the αvβ3 Integrin to Promote Epidermal Growth Factor Receptor Phosphorylation and Growth , 1997, The Journal of cell biology.

[4]  Robert,et al.  Differential regulation of matrix metalloproteinases associated with aging and hypertension in the rat heart. , 1997, Laboratory investigation; a journal of technical methods and pathology.

[5]  K. Weber,et al.  Pathological Hypertrophy and Cardiac Interstitium: Fibrosis and Renin‐Angiotensin‐Aldosterone System , 1991, Circulation.

[6]  E Ruoslahti,et al.  Extracellular signal-regulated kinase and c-Jun NH2-terminal kinase activation by mechanical stretch is integrin-dependent and matrix-specific in rat cardiac fibroblasts. , 1998, The Journal of clinical investigation.

[7]  A. Chobanian,et al.  Angiotensin II-induced cardiac fibrosis in the rat is increased by chronic inhibition of nitric oxide synthase. , 1995, The Journal of clinical investigation.

[8]  A. Tedgui,et al.  Pressure and angiotensin II synergistically induce aortic fibronectin expression in organ culture model of rabbit aorta. Evidence for a pressure-induced tissue renin-angiotensin system. , 1996, Circulation research.

[9]  E. Schiffrin,et al.  Effect of AT1 angiotensin-receptor blockade on structure and function of small arteries in SHR. , 1997, Journal of cardiovascular pharmacology.

[10]  J. Schaper,et al.  The extracellular matrix in human myocardium: Part I: Collagens I, III, IV, and VI. , 1991, Cardioscience.

[11]  B. Doble,et al.  Regulation of Basic Fibroblast Growth Factor (BFGF) and FGF Receptors in the Heart a , 1995, Annals of the New York Academy of Sciences.

[12]  E Ruoslahti,et al.  A 60-kD protein mediates the binding of transforming growth factor-beta to cell surface and extracellular matrix proteoglycans , 1993, The Journal of cell biology.

[13]  V. Koteliansky,et al.  Laminin variants and integrin laminin receptors in developing and adult human smooth muscle. , 1993, Developmental biology.

[14]  K. Baker,et al.  Evidence for a role of an intracardiac renin-angiotensin system in normal and failing hearts. , 1993, Trends in cardiovascular medicine.

[15]  P. Sil,et al.  Angiotensin II and myocyte growth: role of fibroblasts. , 1997, Hypertension.

[16]  L. d’Uscio,et al.  Angiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET(A)-recep , 1997 .

[17]  P. R. Myers,et al.  Oxide Vascular Endothelial Cell Regulation of Extracellular Matrix Collagen : Role of Nitric , 1998 .

[18]  T. Hardingham,et al.  Proteoglycans: many forms and many functions , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  G. Booz,et al.  Cardiac actions of angiotensin II: Role of an intracardiac renin-angiotensin system. , 1992, Annual review of physiology.

[20]  J. Thyberg,et al.  Diverse effects of fibronectin and laminin on phenotypic properties of cultured arterial smooth muscle cells , 1988, The Journal of cell biology.

[21]  D. Mann,et al.  Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds. , 1998, Circulation.

[22]  H. Hämmerle,et al.  Orientation response of arterial smooth muscle cells to mechanical stimulation. , 1986, European journal of cell biology.

[23]  H. Kim,et al.  Expression of extracellular matrix components fibronectin and laminin in the human fetal heart. , 1999, Cell structure and function.

[24]  B. Swynghedauw,et al.  Molecular mechanisms of myocardial remodeling. , 1999, Physiological reviews.

[25]  T. Matsuda,et al.  Mechanical Stress-Induced Orientation and Ultrastructural Change of Smooth Muscle Cells Cultured in Three-Dimensional Collagen Lattices , 1994, Cell transplantation.

[26]  L. Silengo,et al.  Muscle β1D Integrin Reinforces the Cytoskeleton–Matrix Link: Modulation of Integrin Adhesive Function by Alternative Splicing , 1997, The Journal of cell biology.

[27]  P. Oliviéro,et al.  Differential splicing of fibronectin pre-messenger ribonucleic acid during cardiac ontogeny and development of hypertrophy in the rat. , 1994, Laboratory investigation; a journal of technical methods and pathology.

[28]  J. Thiery,et al.  Fibronectin and integrins in development. , 1993, Seminars in cancer biology.

[29]  George Cooper,et al.  Association of Tyrosine-phosphorylated c-Src with the Cytoskeleton of Hypertrophying Myocardium* , 1997, The Journal of Biological Chemistry.

[30]  R. Fandrich,et al.  Basic fibroblast growth factor in atria and ventricles of the vertebrate heart , 1989, The Journal of cell biology.

[31]  G. Rosen,et al.  Expanding roles for alpha 4 integrin and its ligands in development. , 1994, Cell adhesion and communication.

[32]  A. Chobanian,et al.  Effect of hypertension on fibronectin expression in the rat aorta. , 1990, The Journal of biological chemistry.

[33]  HiroakiMatsubara Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases , 1998 .

[34]  S M Schwartz,et al.  Developmental mechanisms underlying pathology of arteries. , 1990, Physiological reviews.

[35]  K. Weber,et al.  Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms. , 1994, Journal of molecular and cellular cardiology.

[36]  Erkki Ruoslahti,et al.  Proteoglycans as modulators of growth factor activities , 1991, Cell.

[37]  A. Sabri,et al.  Fibronectin and basement membrane in cardiovascular organogenesis and disease pathogenesis. , 1996, Cardiovascular research.

[38]  J. Schaper,et al.  The extracellular matrix in human cardiac tissue. Part II: Vimentin, laminin, and fibronectin. , 1992, Cardioscience.

[39]  Y. Toya,et al.  Mechanism of Angiotensin II-mediated Regulation of Fibronectin Gene in Rat Vascular Smooth Muscle Cells* , 1998, The Journal of Biological Chemistry.

[40]  J. Schwarzbauer Fibronectin: from gene to protein. , 1991, Current opinion in cell biology.

[41]  D C Rees,et al.  Heparin Structure and Interactions with Basic Fibroblast Growth Factor , 1996, Science.

[42]  J. Schaper,et al.  The extracellular matrix in the failing human heart. , 1992, Basic research in cardiology.

[43]  Kenneth M. Yamada,et al.  Integrin transmembrane signaling and cytoskeletal control. , 1995, Current opinion in cell biology.

[44]  Richard O. Hynes,et al.  Integrins: Versatility, modulation, and signaling in cell adhesion , 1992, Cell.

[45]  A. Chobanian,et al.  Fibronectin biosynthesis in the rat aorta in vitro. Changes due to experimental hypertension. , 1991, The Journal of clinical investigation.

[46]  K. Weber,et al.  Angiotensin II-induced myocardial fibrosis in rats: role of nitric oxide, prostaglandins and bradykinin. , 1996, Cardiovascular research.

[47]  J. Keiser,et al.  Vascular endothelial growth factor upregulates the expression of matrix metalloproteinases in vascular smooth muscle cells: role of flt-1. , 1998, Circulation research.

[48]  C. Long,et al.  Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts. , 1998, Cardiovascular research.

[49]  Hisahiro Yu,et al.  Prostacyclin release by rat cardiac fibroblasts: inhibition of collagen expression. , 1997, Hypertension.

[50]  A. Chobanian,et al.  Salicylate or aspirin inhibits the induction of the inducible nitric oxide synthase in rat cardiac fibroblasts. , 1996, Circulation research.

[51]  今井 泰平 Induction of endothelin-1 gene by angiotensin and vasopressin in endothelial cells , 1993 .

[52]  S. Schwartz,et al.  Molecular cloning and characterization of 2B7, a rat mRNA which distinguishes smooth muscle cell phenotypes in vitro and is identical to osteopontin (secreted phosphoprotein I, 2aR). , 1991, Biochemical and biophysical research communications.

[53]  P. R. Myers,et al.  Vascular endothelial cell regulation of extracellular matrix collagen: role of nitric oxide. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[54]  R. Weiss,et al.  Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF , 1993, The Journal of cell biology.

[55]  Lorell Bh Transition from hypertrophy to failure. , 1997 .

[56]  J. Thyberg,et al.  Role of tyrosine kinases in extracellular matrix-mediated modulation of arterial smooth muscle cell phenotype. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[57]  J. S. Janicki,et al.  Remodeling of the rat right and left ventricles in experimental hypertension. , 1990, Circulation research.

[58]  Y. Yazaki,et al.  Is there major involvement of the renin-angiotensin system in cardiac hypertrophy? , 1997, Circulation research.

[59]  C. Mickanin,et al.  Cell adhesion receptors and early mammalian heart development: an overview. , 1993, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

[60]  K. Tryggvason,et al.  The laminin family. , 1993, Current opinion in cell biology.

[61]  V. Koteliansky,et al.  Beta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cells , 1996, The Journal of cell biology.

[62]  C. Delcayre,et al.  Biological determinants of aldosterone-induced cardiac fibrosis in rats. , 1995, Hypertension.

[63]  K. Weber,et al.  Cardiac interstitium in health and disease: the fibrillar collagen network. , 1989, Journal of the American College of Cardiology.

[64]  M. Glukhova,et al.  Arterial smooth muscle cell phenotype in stroke-prone spontaneously hypertensive rats. , 1993, Hypertension.

[65]  R. Hynes,et al.  Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. , 1993, Development.

[66]  M. Sporn,et al.  Transforming growth factor-beta: recent progress and new challenges , 1992, The Journal of cell biology.

[67]  G. Hamon,et al.  HR 720, a novel angiotensin receptor antagonist inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro. , 1997, The Journal of pharmacology and experimental therapeutics.

[68]  D E Ingber,et al.  Convergence of integrin and growth factor receptor signaling pathways within the focal adhesion complex. , 1995, Molecular biology of the cell.

[69]  T K Borg,et al.  Expression of collagen binding integrins during cardiac development and hypertrophy. , 1991, Circulation research.

[70]  C. Long,et al.  Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-b and endothelin-1 from fibroblasts 1 , 1998 .

[71]  T. Borg,et al.  Potential Role of the Extracellular Matrix in Postseptation Development of the Heart a , 1990, Annals of the New York Academy of Sciences.

[72]  S. Chien,et al.  Role of integrins in cellular responses to mechanical stress and adhesion. , 1997, Current opinion in cell biology.

[73]  Y. Kihara,et al.  Increased expression of interleukin-1 beta and monocyte chemotactic and activating factor/monocyte chemoattractant protein-1 in the hypertrophied and failing heart with pressure overload. , 1997, Circulation research.

[74]  W. Hsueh,et al.  Integrins, adhesion, and cardiac remodeling. , 1998, Hypertension.

[75]  S. Shapiro,et al.  Matrix metalloproteinase degradation of extracellular matrix: biological consequences. , 1998, Current opinion in cell biology.

[76]  K. Tryggvason,et al.  Primary structure and expression of a novel human laminin alpha 4 chain. , 1995, FEBS letters.

[77]  G. Laurent,et al.  Collagen production and replication by cardiac fibroblasts is enhanced in response to diverse classes of growth factors. , 1995, European journal of cell biology.

[78]  C. Lechene,et al.  Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[79]  B. Lorell Transition from hypertrophy to failure. , 1997, Circulation.

[80]  K. Tryggvason,et al.  Primary structure and expression of a novel human laminin α4 chain , 1995 .

[81]  V. Koteliansky,et al.  Specific alterations in the distribution of extracellular matrix components within rat myocardium during the development of pressure overload. , 1991, Laboratory investigation; a journal of technical methods and pathology.

[82]  Y. Yazaki,et al.  Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes. Possible role of protein kinase C activation. , 1991, The Journal of biological chemistry.

[83]  H. Nagase Matrix metalloproteinases. A mini-review. , 1994, Contributions to nephrology.

[84]  M. Mulvany Resistance vessel growth and remodelling: cause or consequence in cardiovascular disease. , 1995, Journal of human hypertension.

[85]  A. Mebazaa,et al.  Trophic effect of human pericardial fluid on adult cardiac myocytes. Differential role of fibroblast growth factor-2 and factors related to ventricular hypertrophy. , 1997, Circulation research.

[86]  M. Bissell,et al.  Multi‐faceted regulation of cell differentiation by extracellular matrix , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[87]  P. Douglas,et al.  Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. , 1996, Circulation.

[88]  J. Thiery,et al.  Accumulation of fetal fibronectin mRNAs during the development of rat cardiac hypertrophy induced by pressure overload. , 1991, The Journal of clinical investigation.

[89]  P. Poitevin,et al.  Differential roles of AT1 and AT2 receptor subtypes in vascular trophic and phenotypic changes in response to stimulation with angiotensin II. , 1997, Arteriosclerosis, thrombosis, and vascular biology.

[90]  A. Tedgui,et al.  Signal transduction of mechanical stresses in the vascular wall. , 1998, Hypertension.

[91]  H. Ives,et al.  Mechanical strain and collagen potentiate mitogenic activity of angiotensin II in rat vascular smooth muscle cells. , 1993, The Journal of clinical investigation.

[92]  E. Fleck,et al.  Myocardial osteopontin expression is associated with left ventricular hypertrophy. , 1997, Circulation.

[93]  F. Villarreal,et al.  Cardiac hypertrophy-induced changes in mRNA levels for TGF-beta 1, fibronectin, and collagen. , 1992, The American journal of physiology.

[94]  Jussi Taipale,et al.  Growth factors in the extracellular matrix , 1997, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[95]  A. Sabri,et al.  Expression of fibronectin during rat fetal and postnatal development: an in situ hybridisation and immunohistochemical study. , 1994, Cardiovascular research.

[96]  J. Schaper,et al.  Extracellular matrix deposition in hypertensive hearts antifibrotic effects of ramipril. , 1995, European heart journal.

[97]  T. Lüscher,et al.  Angiotensin II increases tissue endothelin and induces vascular hypertrophy: reversal by ET(A)-receptor antagonist. , 1997, Circulation.

[98]  S. Haskill,et al.  Signal transduction from the extracellular matrix , 1993, The Journal of cell biology.