Developing new types of wheat with enhanced health benefits

The consumption of wholegrain wheat is associated with a number of health benefits which may relate to the presence of a range of dietary fibre, phytochemical, vitamin and mineral components. Analysis of 150 bread wheat lines within the HEALTHGRAIN programme showed wide variation in content and composition of bioactive components within 150 bread wheat lines. Furthermore, in some cases (notably arabinoxylan in flour and tocols, sterols and alkylresorcinols in wholemeal) this variation was highly heritable and hence accessible to plant breeders. A number of tools are therefore being developed to facilitate the selection of these components in plant breeding programmes including molecular markers, biochemical kits and NIR calibrations.

[1]  Fabienne Guillon,et al.  Monoclonal antibodies to p-coumarate. , 2009, Phytochemistry.

[2]  Fabienne Guillon,et al.  Generation of polyclonal and monoclonal antibodies against arabinoxylans and their use for immunocytochemical location of arabinoxylans in cell walls of endosperm of wheat , 2004 .

[3]  Catherine Ravel,et al.  The HEALTHGRAIN wheat diversity screen: effects of genotype and environment on phytochemicals and dietary fiber components. , 2010, Journal of agricultural and food chemistry.

[4]  F. Guillon,et al.  Wheat arabinoxylans : Exploiting variation in amount and composition to develop enhanced varieties , 2007 .

[5]  Kaisa Poutanen,et al.  The HEALTHGRAIN Cereal Diversity Screen: concept, results, and prospects. , 2008, Journal of agricultural and food chemistry.

[6]  Peter R. Shewry,et al.  Relationship between the contents of bioactive components in grain and the release dates of wheat lines in the HEALTHGRAIN diversity screen. , 2011, Journal of agricultural and food chemistry.

[7]  Peter R. Shewry,et al.  More of the Grain—Progress in the HEALTHGRAIN Project for Healthy Cereal Foods , 2010 .

[8]  Peter R. Shewry,et al.  Beyond whole grain: The European HEALTHGRAIN project aims at healthier cereal foods , 2008 .

[9]  Fabienne Guillon,et al.  Arabinoxylan and (1→3),(1→4)-β-glucan deposition in cell walls during wheat endosperm development , 2006, Planta.

[10]  A. Lovegrove,et al.  A metabolomic study of substantial equivalence of field-grown genetically modified wheat. , 2006, Plant biotechnology journal.

[11]  S. Craig,et al.  Betaine in human nutrition. , 2004, The American journal of clinical nutrition.

[12]  D. Lafiandra,et al.  Production of novel allelic variation for genes involved in starch biosynthesis through mutagenesis , 2010, Molecular Breeding.

[13]  A. Fardet.  New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre? , 2010, Nutrition Research Reviews.

[14]  Catherine Ravel,et al.  Effects of genotype and environment on the content and composition of phytochemicals and dietary fiber components in rye in the HEALTHGRAIN diversity screen. , 2010, Journal of agricultural and food chemistry.

[15]  Gérard Branlard,et al.  Isolation of the wheat aleurone layer for 2D electrophoresis and proteomics analysis , 2008 .

[16]  M. Migaud,et al.  Application of NMR based metabolomics for mapping metabolite variation in European wheat , 2009, Metabolomics.

[17]  Malcolm J. Hawkesford,et al.  Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling. , 2008, Journal of experimental botany.

[18]  A. Fernie,et al.  Metabolomics-assisted breeding: a viable option for crop improvement? , 2009, Trends in genetics : TIG.

[19]  Paul Dupree,et al.  A Novel Bioinformatics Approach Identifies Candidate Genes for the Synthesis and Feruloylation of Arabinoxylan1[W][OA] , 2007, Plant Physiology.

[20]  S. Praud,et al.  Genomics in cereals: from genome-wide conserved orthologous set (COS) sequences to candidate genes for trait dissection , 2009, Functional & Integrative Genomics.

[21]  Fabienne Guillon,et al.  Investigation of ferulate deposition in endosperm cell walls of mature and developing wheat grains by using a polyclonal antibody , 2007, Planta.

[22]  Steven Henikoff,et al.  Targeted screening for induced mutations , 2000, Nature Biotechnology.

[23]  F. Guillon,et al.  Genetics of dietary fibre in bread wheat , 2009, Euphytica.

[24]  Gérard Branlard,et al.  Mapping and proteomic analysis of albumin and globulin proteins in hexaploid wheat kernels (Triticum aestivum L.) , 2009, Theoretical and Applied Genetics.