It’s a kar9ochore to capture microtubules

Microtubule orientation to cortical spatial cues is essential for the fidelity of asymmetric cellular processes. A cortical microtubule-capture site, composed of Bim1 and Kar9, has now been identified in yeast. Bim1 is the yeast homologue of EB1, a binding partner of the adenomatous polyposis coli (APC), indicating that important features of this complex may be highly conserved.

[1]  J. Yates,et al.  Coronin Promotes the Rapid Assembly and Cross-linking of Actin Filaments and May Link the Actin and Microtubule Cytoskeletons in Yeast , 1999, The Journal of cell biology.

[2]  D. Pellman,et al.  Positioning of the mitotic spindle by a cortical-microtubule capture mechanism. , 2000, Science.

[3]  K. Bloom,et al.  The Role of Actin in Spindle Orientation Changes during the Saccharomyces cerevisiae Cell Cycle , 1999, The Journal of cell biology.

[4]  J. Cooper,et al.  Microtubule Interactions with the Cell Cortex Causing Nuclear Movements in Saccharomyces cerevisiae , 2000, The Journal of cell biology.

[5]  D. Amberg,et al.  The secretory pathway mediates localization of the cell polarity regulator Aip3p/Bud6p. , 2000, Molecular biology of the cell.

[6]  F. Chang Movement of a cytokinesis factor cdc12p to the site of cell division , 1999, Current Biology.

[7]  Kim Nasmyth,et al.  Asymmetric Accumulation of Ash1p in Postanaphase Nuclei Depends on a Myosin and Restricts Yeast Mating-Type Switching to Mother Cells , 1996, Cell.

[8]  J. Cooper,et al.  A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein , 1998, Nature.

[9]  E. Salmon,et al.  The polarity and dynamics of microtubule assembly in the budding yeast Saccharomyces cerevisiae , 1999, Nature Cell Biology.

[10]  E. Salmon,et al.  Microtubule Dynamics from Mating through the First Zygotic Division in the Budding Yeast Saccharomyces cerevisiae , 1999, The Journal of cell biology.

[11]  E. Salmon,et al.  Localization and anchoring of mRNA in budding yeast , 1999, Current Biology.

[12]  S. Shaw,et al.  Astral Microtubule Dynamics in Yeast: A Microtubule-based Searching Mechanism for Spindle Orientation and Nuclear Migration into the Bud , 1997, The Journal of cell biology.

[13]  D. Botstein,et al.  Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites. , 1997, Molecular biology of the cell.

[14]  E. Salmon,et al.  Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae , 1995, The Journal of cell biology.

[15]  John R. Pringle,et al.  Bni1p, a Yeast Formin Linking Cdc42p and the Actin Cytoskeleton During Polarized Morphogenesis , 1997, Science.

[16]  M. Rose,et al.  Kar9p Is a Novel Cortical Protein Required for Cytoplasmic Microtubule Orientation in Yeast , 1998, The Journal of cell biology.

[17]  E. O'Toole,et al.  Yeast Bim1p Promotes the G1-specific Dynamics of Microtubules , 1999, The Journal of cell biology.

[18]  M. Rose,et al.  The Cortical Localization of the Microtubule Orientation Protein, Kar9p, Is Dependent upon Actin and Proteins Required for Polarization , 1999, The Journal of cell biology.

[19]  D. Botstein,et al.  BIM1 encodes a microtubule-binding protein in yeast. , 1997, Molecular biology of the cell.

[20]  A. Chaudhuri,et al.  Molecular linkage underlying microtubule orientation toward cortical sites in yeast. , 2000, Science.

[21]  J. Hegemann,et al.  Mal3, the Fission Yeast Homologue of the Human APC-interacting Protein EB-1 Is Required for Microtubule Integrity and the Maintenance of Cell Form , 1997, Journal of Cell Biology.

[22]  M. Peifer,et al.  Teaching tumour suppressors new tricks , 2000, Nature Cell Biology.

[23]  P. Brennwald Reversal of fortune. Do Rab GTPases act on the target membrane , 2000 .