论文信息 - ZARAMIT: A System for the Evolutionary Study of Human Mitochondrial DNA

ZARAMIT: A System for the Evolutionary Study of Human Mitochondrial DNA

ZARAMIT is an information system capable of fully automated phylogeny reconstruction. Methods have been tailored to mitochondrial DNA sequences, with focus on subproblem partitioning. We have built exhaustive human mitochondrial phylogenies (approximately 5500 sequences) and detected problems in existing haplogroup hierarchies through data-driven classification. Information on the project can be found on zaramit.org .

Roberto Blanco | Elvira Mayordomo | E. Mayordomo | Roberto Blanco

[1] Manfred Kayser,et al. Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation , 2009, Human mutation.

[2] M. Nei,et al. Molecular Evolution and Phylogenetics , 2000 .

[3] Xin Chen,et al. An information-based sequence distance and its application to whole mitochondrial genome phylogeny , 2001, Bioinform..

[4] Jens Gramm,et al. Fixed-parameter Algorithms in Phylogenetics , 2022 .

[5] W. H. Day. Computational complexity of inferring phylogenies from dissimilarity matrices. , 1987, Bulletin of mathematical biology.

[6] Bin Ma,et al. The similarity metric , 2001, IEEE Transactions on Information Theory.

[7] F. Sanger,et al. Sequence and organization of the human mitochondrial genome , 1981, Nature.

[8] David A. Bader,et al. High-Performance Algorithm Engineering for Computational Phylogenetics , 2001, International Conference on Computational Science.

[9] R. Graham,et al. The steiner problem in phylogeny is NP-complete , 1982 .

[10] Tamir Tuller,et al. Maximum likelihood of evolutionary trees: hardness and approximation , 2005, ISMB.

[11] Marty C. Brandon,et al. Effects of Purifying and Adaptive Selection on Regional Variation in Human mtDNA , 2004, Science.

[12] Pierre Baldi,et al. An enhanced MITOMAP with a global mtDNA mutational phylogeny , 2006, Nucleic Acids Res..