Calcium-activated potassium channels

Abstract Ca 2+ -activated K + currents are found in most types of cells. Considerable progress has been made since the development of single channel recording techniques in identifying some of the channels underlying these currents. It is now apparent that there are many types of Ca 2+ -activated K + channels, which differ in their conductances and sensitivity to activation by both [Ca 2+ ] i and voltage. Ca 2+ -activated K + channels couple Ca 2+ metabolism and membrane potential to K + flux and membrane excitability. Ca 2+ -activated K + channels allow and modulate repetitive firing in some neurons and contribute to regulation of secretion in some endocrine and exocrine cells.

[1]  R. Latorre,et al.  Multi-ion conduction and selectivity in the high-conductance Ca++-activated K+ channel from skeletal muscle. , 1986, Biophysical journal.

[2]  D. A. Brown,et al.  Intracellular Ca2+ activates a fast voltage-sensitive K+ current in vertebrate sympathetic neurones , 1982, Nature.

[3]  J. Barrett,et al.  Calcium-dependent slow potassium conductance in rat skeletal myotubes. , 1981, Developmental biology.

[4]  M. Lazdunski,et al.  The coexistence in rat muscle cells of two distinct classes of Ca2+-dependent K+ channels with different pharmacological properties and different physiological functions. , 1984, Biochemical and biophysical research communications.

[5]  K L Magleby,et al.  Properties of single calcium‐activated potassium channels in cultured rat muscle , 1982, The Journal of physiology.

[6]  B. S. Pallotta.  Calcium‐activated potassium channels in rat muscle inactivate from a short‐duration open state. , 1985, The Journal of physiology.

[7]  G. Gardos,et al.  The function of calcium in the potassium permeability of human erythrocytes. , 1958, Biochimica et biophysica acta.

[8]  K. Krnjević,et al.  Injections of calcium ions into spinal motoneurones , 1972, The Journal of physiology.

[9]  K. Magleby,et al.  Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture , 1981, Nature.

[10]  R Latorre,et al.  Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage- dependent Ca2+ binding reactions , 1983, The Journal of general physiology.

[11]  K. Magleby,et al.  Single apamin-blocked Ca-activated K+ channels of small conductance in cultured rat skeletal muscle , 1986, Nature.

[12]  A. Marty,et al.  Ca-dependent K channels with large unitary conductance in chromaffin cell membranes , 1981, Nature.

[13]  K L Magleby,et al.  Calcium dependence of open and shut interval distributions from calcium‐activated potassium channels in cultured rat muscle. , 1983, The Journal of physiology.

[14]  I. Levitan,et al.  Modulation of single Ca2+-dependent K+-channel activity by protein phosphorylation , 1985, Nature.

[15]  A. Marty.  Ca2+-dependent K+ channels with large unitary conductance , 1983, Trends in Neurosciences.

[16]  K. Magleby,et al.  Ion conductance and selectivity of single calcium-activated potassium channels in cultured rat muscle , 1984, The Journal of general physiology.

[17]  K. Magleby,et al.  Inverse relationship of the durations of adjacent open and shut intervals for Cl and K channels , 1985, Nature.

[18]  H Lecar,et al.  Single calcium-dependent potassium channels in clonal anterior pituitary cells. , 1982, Biophysical journal.

[19]  O. Petersen,et al.  Voltage and Ca2+-activated K+ channel in baso-lateral acinar cell membranes of mammalian salivary glands , 1983, Nature.

[20]  O. Petersen,et al.  Calcium-activated potassium channels and their role in secretion , 1984, Nature.

[21]  E. Barrett,et al.  Separation of two voltage‐sensitive potassium currents, and demonstration of a tetrodotoxin‐resistant calcium current in frog motoneurones. , 1976, The Journal of physiology.

[22]  H. Passow,et al.  Ca2+-activated K+ channels in human red cells. Comparison of single-channel currents with ion fluxes. , 1984, Biophysical journal.

[23]  G. Serratrice,et al.  Expression of apamin receptor in muscles of patients with myotonic muscular dystrophy , 1986, Nature.

[24]  R. Meech,et al.  Calcium-dependent potassium activation in nervous tissues. , 1978, Annual review of biophysics and bioengineering.

[25]  R. Latorre,et al.  Charybdotoxin, a protein inhibitor of single Ca2+-activated K+ channels from mammalian skeletal muscle , 1985, Nature.

[26]  J. Golowasch,et al.  Allosteric effects of Mg2+ on the gating of Ca2+-activated K+ channels from mammalian skeletal muscle. , 1986, The Journal of experimental biology.