ANTI-TUMOR ACTIVITIES OF GELATIN

Previously we have shown that bovine bone (BB) gelatin stimulated proliferation of murine spleen cells in vitro [1]. BB and porcine skin (PS) gelatins stimulated murine peritoneal macrophages (mPMs) to secrete several cyokines, e. g., interleukin (IL)-6, IL-12, TNF-α and MCP-1 [2]. PS gelatin suppressed proliferation of cells of human as well as murine cell lines [1, 3, 4]. Recently we observed that PS gelatin stimulated murine anti-tumor peritoneal macrophages [5]. The ability of PS gelatin to induce anti-tumor peritoneal macrophages was greater than LPS or interferon-γ (IFN-γ). In this study, we investigated whether or not three kinds of gelatin including PS gelatin exerted anti-tumor activity in vivo.

[1]  Y. Hashimoto,et al.  Anti-tumor activity of murine peritoneal macrophages induced by porcine skin gelatin. , 2008, Experimental oncology.

[2]  H. Nagata,et al.  Activity of gelatins to induce secretion of a variety of cytokines from murine peritoneal exudate macrophages. , 2005, Cancer biotherapy & radiopharmaceuticals.

[3]  Yasuko Tomizawa,et al.  Clinical benefits and risk analysis of topical hemostats: a review , 2005, Journal of Artificial Organs.

[4]  I. Yannas,et al.  Antigenicity and immunogenicity of collagen. , 2004, Journal of biomedical materials research. Part B, Applied biomaterials.

[5]  Sung Hwa Hong,et al.  Biocompatibility and biodegradation of cross-linked gelatin/hyaluronic acid sponge in rat subcutaneous tissue , 2004, Journal of biomaterials science. Polymer edition.

[6]  M. Sano,et al.  Effect of gelatins on human cancer cells in vitro. , 2003, Cancer biotherapy & radiopharmaceuticals.

[7]  K. Maruyama,et al.  Intracellular targeting therapy of cisplatin‐encapsulated transferrin‐polyethylene glycol liposome on peritoneal dissemination of gastric cancer , 2002, International journal of cancer.

[8]  S. Noh,et al.  Treatment of advanced gastric cancer by palliative gastrectomy, cytoreductive therapy and postoperative intraperitoneal chemotherapy , 2002, The British journal of surgery.

[9]  伊藤 暢宏.  Apoptosis induced by culturing MH134 cells in the presence of porcine skin gelatin in vitro , 2002 .

[10]  S. Tsujitani,et al.  The administration of hypotonic intraperitoneal cisplatin during operation as a treatment for the peritoneal dissemination of gastric cancer. , 2002, Surgery.

[11]  M. Sano,et al.  In vitro effect of gelatins on murine cell proliferation. , 2001, Cancer biotherapy & radiopharmaceuticals.

[12]  J. Roh,et al.  Early Postoperative Intraperitoneal Chemotherapy with Mitomycin C, 5-Fluorouracil and Cisplatin for Advanced Gastric Cancer , 2000, Oncology.

[13]  W. Schimetta,et al.  Hydroxyethyl Starch Antibodies in Humans: Incidence and Clinical Relevance , 1998, Anesthesia and analgesia.

[14]  S. Omura,et al.  A carrier for clinical use of recombinant human BMP-2: dehydrothermally cross-linked composite of fibrillar and denatured atelocollagen sponge. , 1998, International journal of oral and maxillofacial surgery.

[15]  R. Jakesz,et al.  Adjuvant intraperitoneal cisplatin chemotherapy does not improve long-term survival after surgery for advanced gastric cancer. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[16]  H. Maeda,et al.  Conjugation of Cu,Zn-superoxide dismutase with succinylated gelatin: pharmacological activity and cell-lubricating function. , 1993, Bioconjugate chemistry.

[17]  B. Sevin,et al.  Synergistic effects of cis-platinum and cytosine arabinoside on ovarian carcinoma cell lines, demonstrated by dual-parameter flow cytometry. , 1987, Gynecologic oncology.