Food‐related anaphylaxis fatalities: Analysis of the Allergy Vigilance Network® database

respectively. Similar observations were made by other authors, which is intriguing considering the rapid re‐synthesis of IgE and fast recovery of individual IgE levels in <2 weeks. The mechanism of action remains unclear and may range from depletion of allergen‐ or pathogen‐specific IgE to reduction in tissue‐ bound IgE. In addition, alterations in the level of autoreactive IgE may also be possible. In summary, in the present 12 case series, we have observed that repetitive, transient reductions of total IgE in AD lead to long‐lasting improvement of AD. In patients previously unresponsive to extensive guideline therapy, both clinical parameters as well as the quality of life were strongly improved. The results suggest that IgE potentially represents an important therapeutic target in AD and controlled trials assessing the efficacy of IgE‐selective IA for larger AD patient cohorts are urgently needed.