Nitric oxide contributes to cytokine-induced apoptosis in pancreatic beta cells via potentiation of JNK activity and inhibition of Akt

[1]  D. Maysinger,et al.  Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. , 2004, Endocrinology.

[2]  N. Demartines,et al.  Successful Simultaneous Islet‐Kidney Transplantation using a Steroid‐free Immunosuppression: Two‐Year Follow‐up , 2004, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[3]  C. Carlsson,et al.  Cytokine-induced PGE2 formation is reduced from iNOS deficient murine islets , 2004, Molecular and Cellular Endocrinology.

[4]  J. Haefliger,et al.  Variations in IB1/JIP1 expression regulate susceptibility of beta-cells to cytokine-induced apoptosis irrespective of C-Jun NH2-terminal kinase signaling. , 2003, Diabetes.

[5]  J. Corbett,et al.  Role for c-Jun N-terminal kinase in beta-cell recovery from nitric oxide-mediated damage. , 2003, Endocrinology.

[6]  L. Boxer,et al.  Cytokine-mediated Down-regulation of the Transcription Factor cAMP-response Element-binding Protein in Pancreatic β-Cells* , 2003, Journal of Biological Chemistry.

[7]  S. L. Gurun,et al.  The scaffold protein IB1/JIP-1 is a critical mediator of cytokine-induced apoptosis in pancreatic β cells , 2003, Journal of Cell Science.

[8]  B. Hemmings,et al.  PKB Binding Proteins Getting in on the Akt , 2002, Cell.

[9]  E. Ayuso,et al.  β cell expression of IGF-I leads to recovery from type 1 diabetes , 2002 .

[10]  E. Ayuso,et al.  Beta cell expression of IGF-I leads to recovery from type 1 diabetes. , 2002, The Journal of clinical investigation.

[11]  T. Mandrup-Poulsen,et al.  A choice of death – the signal-transduction of immune-mediated beta-cell apoptosis , 2001, Diabetologia.

[12]  F. Sobrino,et al.  Sodium nitroprusside-induced mitochondrial apoptotic events in insulin-secreting RINm5F cells are associated with MAP kinases activation. , 2001, Experimental cell research.

[13]  John C. Lee,et al.  Role of p38 mitogen-activated protein kinase (p38 MAPK) in cytokine-induced rat islet cell apoptosis. , 2001, Biochemical pharmacology.

[14]  I. Weinstein,et al.  Protein Kinase G Activates the JNK1 Pathway via Phosphorylation of MEKK1* , 2001, The Journal of Biological Chemistry.

[15]  A. Andersson,et al.  Cytokine-induced inhibition of insulin release from mouse pancreatic beta-cells deficient in inducible nitric oxide synthase. , 2001, Biochemical and biophysical research communications.

[16]  Xuan Sun,et al.  Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1 , 2001, Molecular and Cellular Biology.

[17]  D. Schorderet,et al.  Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. , 2001, Diabetes.

[18]  E. Furth,et al.  Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. , 2001, Nature medicine.

[19]  D. Schorderet,et al.  Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of β-Cell Death , 2001 .

[20]  E. Choi,et al.  Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means of S-nitrosylation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M. Trucco,et al.  Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor I , 2000, Gene Therapy.

[22]  R. Davis,et al.  Signal Transduction by the JNK Group of MAP Kinases , 2000, Cell.

[23]  G. Piazza,et al.  Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[24]  P. Serup,et al.  The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells. , 2000, Diabetes.

[25]  D. Eizirik,et al.  Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokine-induced apoptosis in purified rat pancreatic beta-cells. , 2000, European cytokine network.

[26]  Dongbo Liu,et al.  Cytokines induce apoptosis in beta-cells isolated from mice lacking the inducible isoform of nitric oxide synthase (iNOS-/-). , 2000, Diabetes.

[27]  G. Waeber,et al.  IB1 Reduces Cytokine-induced Apoptosis of Insulin-secreting Cells* , 2000, The Journal of Biological Chemistry.

[28]  T. Tan,et al.  The c-Jun N-terminal kinase pathway and apoptotic signaling (review). , 2000, International journal of oncology.

[29]  L. Boscá,et al.  Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of phosphatidylinositol 3-kinase. , 2000, Diabetes.

[30]  G. Holländer,et al.  Nitric oxide production and Fas surface expression mediate two independent pathways of cytokine-induced murine beta-cell damage. , 2000, Diabetes.

[31]  S. R. Datta,et al.  Cellular survival: a play in three Akts. , 1999, Genes & development.

[32]  B. Tyrberg,et al.  Reduced sensitivity of inducible nitric oxide synthase-deficient mice to multiple low-dose streptozotocin-induced diabetes. , 1999, Diabetes.

[33]  J. Petrik,et al.  Insulin-like growth factors prevent cytokine-mediated cell death in isolated islets of Langerhans from pre-diabetic non-obese diabetic mice. , 1999, The Journal of endocrinology.

[34]  R. Park,et al.  Overexpression of protein kinase C isoforms protects RAW 264.7 macrophages from nitric oxide-induced apoptosis: involvement of c-Jun N-terminal kinase/stress-activated protein kinase, p38 kinase, and CPP-32 protease pathways. , 1999, Journal of immunology.

[35]  J. Pfeilschifter,et al.  Nitric oxide stimulates the stress-activated protein kinase p38 in rat renal mesangial cells. , 1999, The Journal of experimental biology.

[36]  B. Brüne,et al.  Role of mitogen-activated protein kinases in S-nitrosoglutathione-induced macrophage apoptosis. , 1999, Biochemistry.

[37]  R. Ye,et al.  Activation of p38 Mitogen-activated Protein Kinase by Lipopolysaccharide in Human Neutrophils Requires Nitric Oxide-dependent cGMP Accumulation* , 1999, The Journal of Biological Chemistry.

[38]  C. Martínez-A,et al.  Role of Akt and c-Jun N-terminal kinase 2 in apoptosis induced by interleukin-4 deprivation. , 1998, Molecular biology of the cell.

[39]  D. Le Roith,et al.  Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase* , 1998, The Journal of Biological Chemistry.

[40]  M. Green,et al.  Growth factor protection against cytokine‐induced apoptosis in neonatal rat islets of Langerhans: role of Fas , 1998, FEBS letters.

[41]  M. Su,et al.  Interleukin-1β-induced Rat Pancreatic Islet Nitric Oxide Synthesis Requires Both the p38 and Extracellular Signal-regulated Kinase 1/2 Mitogen-activated Protein Kinases* , 1998, The Journal of Biological Chemistry.

[42]  D. Eizirik,et al.  Is there a role for nitric oxide in beta-cell dysfunction and damage in IDDM? , 1997, Diabetes/metabolism reviews.

[43]  J. Mabley,et al.  Insulin‐like growth factor I reverses interleukin‐1β inhibition of insulin secretion, induction of nitric oxide synthase and cytokine‐mediated apoptosis in rat islets of Langerhans , 1997 .

[44]  E. Choi,et al.  Nitric oxide modulates the c-Jun N-terminal kinase/stress-activated protein kinase activity through activating c-Jun N-terminal kinase kinase. , 1997, Biochemistry.

[45]  J. Pfeilschifter,et al.  Nitric oxide stimulates stress‐activated protein kinases in glomerular endothelial and mesangial cells , 1996, FEBS letters.

[46]  K. Kida,et al.  Insulin-like growth factor I (IGF-I) delays the onset of diabetes in non-obese diabetic (NOD) mice. , 1996, Diabetes research and clinical practice.

[47]  H. Lander,et al.  Differential Activation of Mitogen-activated Protein Kinases by Nitric Oxide-related Species* , 1996, The Journal of Biological Chemistry.

[48]  J. Lakey,et al.  Human pancreatic islet beta-cell destruction by cytokines is independent of nitric oxide production. , 1994, The Journal of clinical endocrinology and metabolism.

[49]  N. Welsh,et al.  Cytokines suppress human islet function irrespective of their effects on nitric oxide generation. , 1994, The Journal of clinical investigation.

[50]  M. Mcdaniel,et al.  Nitric oxide mediates cytokine-induced inhibition of insulin secretion by human islets of Langerhans. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[51]  S. Sandler,et al.  Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. , 1987, Endocrinology.