Cryostructuring of Polymeric Systems. 50. Cryogels and Cryotropic Gel-Formation: Terms and Definitions

A variety of cryogenically-structured polymeric materials are of significant scientific and applied interest in various areas. However, in spite of considerable attention to these materials and intensive elaboration of their new examples, as well as the impressive growth in the number of the publications and patents on this topic over the past two decades, a marked variability of the used terminology and definitions is frequently met with in the papers, reviews, theses, patents, conference presentations, advertising materials and so forth. Therefore, the aim of this brief communication is to specify the basic terms and definitions in the particular field of macromolecular science.

[1]  J. San Román,et al.  Macroporous Scaffolds Based on Chitosan and Bioactive Molecules† , 2007 .

[2]  R. Girolamo,et al.  Kinetic Analysis of Cryotropic Gelation of Poly(Vinyl Alcohol)/Water Solutions by Small-Angle Neutron Scattering , 2014 .

[3]  Charles K. S. Moy,et al.  Development and characteristics of polymer monoliths for advanced LC bioscreening applications: A review. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[4]  Ashok Kumar,et al.  The physical characterization of supermacroporous poly(N-isopropylacrylamide) cryogel: Mechanical strength and swelling/de-swelling kinetics , 2007 .

[5]  A. Denizli,et al.  Poly(hydroxyethyl methacrylate) based affinity cryogel for plasmid DNA purification. , 2011, International journal of biological macromolecules.

[6]  B. Trzebicka,et al.  Super‐macroporous dextran cryogels via UV‐induced crosslinking: synthesis and characterization , 2017 .

[7]  V. Lozinsky,et al.  Study of cryostructurization of polymer systems , 1982 .

[8]  K. Schmidt-Rohr,et al.  Microstructure of poly(vinyl alcohol) hydrogels produced by freeze/thaw cycling , 1999 .

[9]  T. Burova,et al.  Cryostructuring of polymer systems. XXIX. Preparation and characterization of supermacroporous (spongy) agarose‐based cryogels used as three‐dimensional scaffolds for culturing insulin‐producing cell aggregates , 2008 .

[10]  O. Okay,et al.  Macroporous Polyisobutylene Gels: A Novel Tough Organogel with Superfast Responsivity , 2007 .

[11]  V. Lozinsky,et al.  Cryoimmobilized enzymes and cells in organic synthesis , 1992 .

[12]  S. Sell,et al.  A comprehensive review of cryogels and their roles in tissue engineering applications. , 2017, Acta biomaterialia.

[13]  I. Kaetsu,et al.  Radiation synthesis of polymeric materials for biomedical and biochemical applications , 1993 .

[14]  T. Zikmund,et al.  Chondrogenic potential of macroporous biodegradable cryogels based on synthetic poly(α-amino acids). , 2018, Soft matter.

[15]  J. Vial,et al.  Imaging the Structure of Macroporous Hydrogels by Two-Photon Fluorescence Microscopy , 2009 .

[16]  J. Rouzaud,et al.  Carbon aerogels, cryogels and xerogels: Influence of the drying method on the textural properties of porous carbon materials , 2005 .

[17]  V. Y. Grinberg,et al.  Cryostructuring of polymer systems. 44. Freeze-dried and then chemically cross-linked wide porous cryostructurates based on serum albumin , 2017 .

[18]  S. Han,et al.  Preparation and characterization of polyacrylamide cryogels produced from a high‐molecular‐weight precursor. II. The influence of the molecular weight of the polymeric precursor , 2008 .

[19]  R. Zhuo,et al.  A novel method to prepare a fast responsive, thermosensitive poly(N-isopropylacrylamide) hydrogel , 1999 .

[20]  Aleksandra M Urbanska,et al.  Agarose-based biomaterials for tissue engineering. , 2018, Carbohydrate polymers.

[21]  D. S. Hage,et al.  Affinity monolith chromatography: A review of general principles and applications , 2017, Electrophoresis.

[22]  L. Lidgren,et al.  Cell factory‐derived bioactive molecules with polymeric cryogel scaffold enhance the repair of subchondral cartilage defect in rabbits , 2017, Journal of tissue engineering and regenerative medicine.

[23]  Takeo Suzuki,et al.  Preparation of mesoporous carbon by freeze drying , 1999 .

[24]  Tao Wu,et al.  Freeze-thaw induced gelation of alginates. , 2016, Carbohydrate polymers.

[25]  L. Altunina,et al.  Effect of cryogel on soil properties , 2014, Eurasian Soil Science.

[26]  Anamika Singh,et al.  Oxygen-Releasing Antioxidant Cryogel Scaffolds with Sustained Oxygen Delivery for Tissue Engineering Applications. , 2018, ACS applied materials & interfaces.

[27]  Chuanjin Huang,et al.  Freeze Casting for Assembling Bioinspired Structural Materials , 2017, Advanced materials.

[28]  B. Mattiasson,et al.  Macroporous Polymers : Production Properties and Biotechnological/Biomedical Applications , 2009 .

[29]  I. Norton,et al.  Role of gellan gum microstructure in freeze drying and rehydration mechanisms , 2018 .

[30]  L. Qian,et al.  Controlled freezing and freeze drying: a versatile route for porous and micro‐/nano‐structured materials , 2011 .

[31]  B. Mattiasson,et al.  Chromatography of living cells using supermacroporous hydrogels, cryogels. , 2007, Advances in biochemical engineering/biotechnology.

[32]  L. Matějka,et al.  Super porous organic–inorganic poly(N-isopropylacrylamide)-based hydrogel with a very fast temperature response , 2007 .

[33]  F. Monteiro,et al.  Biodegradation, biocompatibility, and osteoconduction evaluation of collagen-nanohydroxyapatite cryogels for bone tissue regeneration. , 2016, Journal of biomedical materials research. Part A.

[34]  Bo Mattiasson,et al.  Polymeric cryogels as promising materials of biotechnological interest. , 2003, Trends in biotechnology.

[35]  Nikolaos A. Peppas,et al.  Structure and Morphology of Freeze/Thawed PVA Hydrogels , 2000 .

[36]  M. Schnabelrauch,et al.  Biocompatible polysaccharide-based cryogels. , 2014, Materials science & engineering. C, Materials for biological applications.

[37]  M. Dumont,et al.  Synthesis and characterization of zein-based cryogels and their potential as diesel fuel absorbent , 2017 .

[38]  M. Çorman Poly-l-lysine modified cryogels for efficient bilirubin removal from human plasma. , 2018, Colloids and surfaces. B, Biointerfaces.

[39]  A. Nussinovitch,et al.  MECHANICAL PROPERTIES OF WEAK LOCUST BEAN GUM (LBG) GELS UNDER CONTROLLED RAPID FREEZE‐THAWING , 2003 .

[40]  V. Lozinsky,et al.  Study of cryostructuring of polymer systems. 33. Effect of rate of chilling aqueous poly(vinyl alcohol) solutions during their freezing on physicochemical properties and porous structure of resulting cryogels , 2012, Colloid Journal.

[41]  S. Han,et al.  Preparation and characterization of polyacrylamide cryogels produced from a high‐molecular‐weight precursor. I. Influence of the reaction temperature and concentration of the crosslinking agent , 2007 .

[42]  B. Mattiasson,et al.  The potential of polymeric cryogels in bioseparation , 2001, Bioseparation.

[43]  M. Gutiérrez,et al.  Ice-Templated Materials: Sophisticated Structures Exhibiting Enhanced Functionalities Obtained after Unidirectional Freezing and Ice-Segregation-Induced Self-Assembly† , 2008 .

[44]  V. Lozinsky,et al.  Swelling behavior of poly(vinyl alcohol) cryogels employed as matrices for cell immobilization , 1996 .

[45]  V. Lozinsky,et al.  Study of cryostructurization of polymer systems , 1984 .

[46]  A. Zelikin,et al.  Poly(vinyl alcohol) physical hydrogels: new vista on a long serving biomaterial. , 2011, Macromolecular bioscience.

[47]  M. Kumakura Preparation method of porous polymer materials by radiation technique and its application , 2001 .

[48]  V. Lozinsky,et al.  Study of cryostructurization of polymer systems. X: 1H- and 2H-NMR studies of the formation of crosslinked polyacrylamide cryogels , 1993 .

[49]  Yanan Du,et al.  Biomaterials as carrier, barrier and reactor for cell-based regenerative medicine , 2015, Protein & Cell.

[50]  Tawatchai Charinpanitkul,et al.  Synthesis of Porous Materials and Their Microstructural Control through Ice Templating , 2013 .

[51]  G. Sergeev,et al.  Reactions in Frozen Multicomponent Systems , 1976 .

[52]  Molly S. Shoichet,et al.  Polymer Scaffolds for Biomaterials Applications , 2010 .

[53]  O. Okay,et al.  Basic Principles of Cryotropic Gelation , 2014 .

[54]  R. Zhuo,et al.  Preparation of fast responsive, temperature-sensitive poly(N-isopropylacrylamide) hydrogel , 1999 .

[55]  I. I. Kurochkin,et al.  Study of cryostructuring of polymer systems: 27. Physicochemical properties of poly(vinyl alcohol) cryogels and specific features of their macroporous morphology , 2007 .

[56]  Barbara D Boyan,et al.  A review of polyvinyl alcohol and its uses in cartilage and orthopedic applications. , 2012, Journal of biomedical materials research. Part B, Applied biomaterials.

[57]  M. Karlsson,et al.  Pore structure in supermacroporous polyacrylamide based cryogels. , 2005, Soft matter.

[58]  Nikolaos A. Peppas,et al.  Structure and Applications of Poly(vinyl alcohol) Hydrogels Produced by Conventional Crosslinking or by Freezing/Thawing Methods , 2000 .

[59]  B. Rutt,et al.  Polyvinyl alcohol cryogel: An ideal phantom material for MR studies of arterial flow and elasticity , 1997, Magnetic resonance in medicine.

[60]  A. Suzuki,et al.  Swelling and mechanical properties of physically crosslinked poly(vinyl alcohol) hydrogels , 2015, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

[61]  H. Oikawa,et al.  Relationship between swollen network structure of rubber vulcanizates and mechanism of freezing point depression of swelling solvent , 1989 .

[62]  V. Lozinsky Cryotropic gelation of poly(vinyl alcohol) solutions , 1998 .

[63]  S. Agarwal,et al.  Low-Density Open Cellular Sponges as Functional Materials. , 2017, Angewandte Chemie.

[64]  E. Dragan,et al.  Design and applications of interpenetrating polymer network hydrogels. A review , 2014 .

[65]  N. N. Vasiliev,et al.  A review on the development of reinforced ice for use as a building material in cold regions , 2015 .

[66]  O. Okay,et al.  Ethidium bromide binding to DNA cryogels , 2013 .

[67]  T. Komai,et al.  Cryogelation in vitro. , 2001, International journal of biological macromolecules.

[68]  O. Okay,et al.  Macroporous rubber gels as reusable sorbents for the removal of oil from surface waters , 2010 .

[69]  V. Lozinsky A Brief History of Polymeric Cryogels , 2014 .

[70]  M. D’Este,et al.  Calcium phosphate/polyvinyl alcohol composite hydrogels: A review on the freeze-thawing synthesis approach and applications in regenerative medicine , 2017 .

[71]  V. Lozinsky,et al.  Study of cryostructuration of polymer systems:: XIII. Some characteristic features of the behaviour of macromolecular thiols in frozen aqueous solutions , 2000 .

[72]  O. Okay DNA hydrogels: New functional soft materials , 2011 .

[73]  I. Norton,et al.  Study of cryostructuration of polymer systems. XVIII. Freeze-thaw influence on water-solubilized artificial mixtures of amylopectin and amylose , 2000 .

[74]  V. Lozinsky,et al.  Cryotropic gelation of ovalbumin solutions , 1997 .

[75]  Ashok Kumar,et al.  Thermoresponsive poly(N-vinylcaprolactam) cryogels: synthesis and its biophysical evaluation for tissue engineering applications , 2010, Journal of materials science. Materials in medicine.

[76]  V. Minim,et al.  Cryogel Poly(acrylamide): Synthesis, Structure and Applications , 2014 .

[77]  V. Y. Grinberg,et al.  Cryostructuring of polymer systems. Proteinaceous wide-pore cryogels generated by the action of denaturant/reductant mixtures on bovine serum albumin in moderately frozen aqueous media. , 2015, Soft matter.

[78]  A. Pestov,et al.  Polyethyleneimine cryogels for metal ions sorption , 2018 .

[79]  V. Lozinsky,et al.  Cryostructuring of polymer systems. 47. Preparation of wide porous gelatin-based cryostructurates in sterilizing organic media and assessment of the suitability of thus formed matrices as spongy scaffolds for 3D cell culturing , 2018 .

[80]  Nathaniel S. Hwang,et al.  Heparin Functionalized Injectable Cryogel with Rapid Shape-Recovery Property for Neovascularization. , 2018, Biomacromolecules.

[81]  Keith M. McLean,et al.  Cryogels for biomedical applications. , 2013, Journal of materials chemistry. B.

[82]  B. Mattiasson Cryogels for Biotechnological Applications , 2014 .

[83]  V. Lozinsky,et al.  Enzymatic Biocatalysts Immobilized on/in the Cryogel-Type Carriers , 2016 .

[84]  Hongbin Zhang,et al.  Physically crosslinked hydrogels from polysaccharides prepared by freeze–thaw technique , 2013 .

[85]  R Geidobler,et al.  Controlled ice nucleation in the field of freeze-drying: fundamentals and technology review. , 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[86]  A. Romero,et al.  Microstructural, mechanical, and histological evaluation of modified alginate-based scaffolds. , 2016, Journal of biomedical materials research. Part A.

[87]  U. Kandalam,et al.  Three-dimensional macroporous materials for tissue engineering of craniofacial bone. , 2017, The British journal of oral & maxillofacial surgery.

[88]  W. Kuhn,et al.  Freezing point depression of gels produced by high polymer network , 1955 .

[89]  N. Platé,et al.  Thermoresponsible cryogels based on cross-linked poly(N,N-diethylacrylamide) , 1997 .

[90]  Peter R Hoskins,et al.  Simulation and validation of arterial ultrasound imaging and blood flow. , 2008, Ultrasound in medicine & biology.

[91]  B. Mattiasson,et al.  Cryogel applications in microbiology. , 2008, Trends in microbiology.

[92]  V. Lozinsky,et al.  Coupling of gelatin to inner surfaces of pore walls in spongy alginate-based scaffolds facilitates the adhesion, growth and differentiation of human bone marrow mesenchymal stromal cells , 2011, Journal of materials science. Materials in medicine.

[93]  Ashok Kumar Supermacroporous Cryogels : Biomedical and Biotechnological Applications , 2016 .

[94]  I. I. Kurochkin,et al.  Study of cryostructuring of polymer systems: 28. Physicochemical properties and morphology of poly(vinyl alcohol) cryogels formed by multiple freezing-thawing , 2008 .

[95]  A. Sieron,et al.  Biocompatible cryogels of thermosensitive polyglycidol derivatives with ultra-rapid swelling properties , 2011 .

[96]  E. Morris,et al.  Cryogelation of xanthan , 2003 .

[97]  Nam Soo Kim,et al.  Collagen/chitosan porous bone tissue engineering composite scaffold incorporated with Ginseng compound K. , 2016, Carbohydrate polymers.

[98]  F. Plieva,et al.  Poly(vinyl alcohol) cryogels employed as matrices for cell immobilization. 3. Overview of recent research and developments , 1998 .

[99]  B. Mattiasson,et al.  Porous protein-based scaffolds prepared through freezing as potential scaffolds for tissue engineering , 2012, Journal of Materials Science: Materials in Medicine.

[100]  Steffen Staab,et al.  Web Science , 2013, Informatik-Spektrum.

[101]  V. Gun'ko,et al.  Cryogels: morphological, structural and adsorption characterisation. , 2013, Advances in colloid and interface science.

[102]  I. Norton,et al.  Study of cryostructuring of polymer systems. XIX. On the nature of intermolecular links in the cryogels of locust bean gum , 2000 .

[103]  B. Mattiasson,et al.  Macroporous gels prepared at subzero temperatures as novel materials for chromatography of particulate-containing fluids and cell culture applications. , 2007, Journal of separation science.

[104]  Helium Mak,et al.  Poly(Vinyl Alcohol) Cryogels for Biomedical Applications , 2014 .

[105]  V. Lozinsky Polymeric cryogels as a new family of macroporous and supermacroporous materials for biotechnological purposes , 2008 .

[106]  O. Okay Polymeric Cryogels: Macroporous Gels with Remarkable Properties , 2014 .

[107]  D. Connolly,et al.  Supermacroporous polyHIPE and cryogel monolithic materials as stationary phases in separation science: a review , 2015 .

[108]  S. Reichelt Introduction to macroporous cryogels. , 2015, Methods in molecular biology.

[109]  O. Okay,et al.  Synthesis and Structure-Property Relationships of Cryogels , 2014 .

[110]  V. Lozinsky Cryogels on the basis of natural and synthetic polymers: preparation, properties and application , 2002 .

[111]  O. Okaya,et al.  Macroporous copolymer networks , 2000 .

[112]  G. Palmese,et al.  The role of crystallization and phase separation in the formation of physically cross-linked PVA hydrogels , 2013 .

[113]  S. Vlierberghe Crosslinking strategies for porous gelatin scaffolds , 2016 .

[114]  L. Lazzeri Progress in bioartificial polymeric materials , 1996 .

[115]  F. Švec Porous polymer monoliths: amazingly wide variety of techniques enabling their preparation. , 2010, Journal of chromatography. A.

[116]  A. Eliopoulos,et al.  Chitosan/gelatin scaffolds support bone regeneration , 2018, Journal of Materials Science: Materials in Medicine.

[117]  D. Tuncaboylu,et al.  Porous rubber cryogels: effect of the gel preparation temperature , 2014, Polymer Bulletin.

[118]  Preparation of Chitosan Cryostructurates with Controlled Porous Morphology and Their Use as 3D-Scaffolds for the Cultivation of Animal Cells , 2018, Applied Biochemistry and Microbiology.

[119]  R. T. Olsson,et al.  Freeze-dried wheat gluten biofoams; scaling up with water welding , 2017 .

[120]  A. Denizli,et al.  Affinity based and molecularly imprinted cryogels: Applications in biomacromolecule purification. , 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[121]  T. Peters,et al.  Poly(vinyl alcohol) cryogel phantoms for use in ultrasound and MR imaging , 2004, Physics in medicine and biology.

[122]  H. Hatakeyama,et al.  Gel–sol transition of poly(vinyl alcohol) hydrogels formed by freezing and thawing , 2005 .

[123]  A. Semenov,et al.  Cryochemical synthesis and antibacterial activity of hybrid nanocomposites based on dioxidine containing Ag and Cu nanoparticles incorporated in biopolymer cryostructurates , 2017, Russian Chemical Bulletin.

[124]  N. Sahiner Super macroporous poly(N‐isopropyl acrylamide) cryogel for separation purpose , 2018 .

[125]  P. Scales,et al.  3D-printing of dynamic self-healing cryogels with tuneable properties , 2018 .

[126]  Ashok Kumar,et al.  Methods in cell separation for biomedical application: cryogels as a new tool , 2008, Biomedical materials.

[127]  B. Mattiasson,et al.  Macroporous Polysaccharide Gels , 2009 .