T-cell-antigen recognition and the immunological synapse

[1]  S. Takahashi,et al.  ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. , 2001, Immunity.

[2]  L. Turka,et al.  The Proliferative Capacity of Individual Naive CD4+T Cells Is Amplified by Prolonged T Cell Antigen Receptor Triggering , 2002, The Journal of experimental medicine.

[3]  J. Bluestone,et al.  Molecular basis of T cell inactivation by CTLA-4. , 1998, Science.

[4]  J. Dennis,et al.  Negative regulation of T-cell activation and autoimmunity by Mgat5 N-glycosylation , 2001, Nature.

[5]  P. Merwe,et al.  The immunological synapse: required for T cell receptor signalling or directing T cell effector function? , 2001, Current Biology.

[6]  Jan Cerny,et al.  T-cell engagement of dendritic cells rapidly rearranges MHC class II transport , 2002, Nature.

[7]  N. Burroughs,et al.  Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse. , 2002, Biophysical journal.

[8]  Kenneth G. Johnson,et al.  Polar Redistribution of the Sialoglycoprotein CD43: Implications for T Cell Function1 , 2002, The Journal of Immunology.

[9]  Patricia L. Widder,et al.  A Novel Adaptor Protein Orchestrates Receptor Patterning and Cytoskeletal Polarity in T-Cell Contacts , 1998, Cell.

[10]  W. Paul,et al.  Regulation of B‐Lymphocyte Activation, Proliferation, and Differentiation , 1987, Annals of the New York Academy of Sciences.

[11]  P. Matzinger.  The Danger Model: A Renewed Sense of Self , 2002, Science.

[12]  Colin R. F. Monks,et al.  Three-dimensional segregation of supramolecular activation clusters in T cells , 1998, Nature.

[13]  Mark J. Miller,et al.  Autonomous T cell trafficking examined in vivo with intravital two-photon microscopy , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[14]  R A Mathies,et al.  Single-molecule fluorescence detection: autocorrelation criterion and experimental realization with phycoerythrin. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[15]  M. Poenie,et al.  Dynamic polarization of the microtubule cytoskeleton during CTL-mediated killing. , 2002, Immunity.

[16]  Mark M. Davis,et al.  Imaging synapse formation during thymocyte selection: inability of CD3zeta to form a stable central accumulation during negative selection. , 2002, Immunity.

[17]  J. Olivo-Marin,et al.  The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. , 2001, Immunity.

[18]  R. Germain,et al.  Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. , 2001, Immunity.

[19]  Fabrice Lemaitre,et al.  T cell adhesion lowers the threshold for antigen detection , 2003, European journal of immunology.

[20]  A. Kupfer,et al.  Reorientation of the microtubule-organizing center and the Golgi apparatus in cloned cytotoxic lymphocytes triggered by binding to lysable target cells. , 1984, Journal of immunology.

[21]  Emil R. Unanue,et al.  Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation , 1990, Nature.

[22]  M. Davis,et al.  A receptor/cytoskeletal movement triggered by costimulation during T cell activation. , 1998, Science.

[23]  R. Steinman,et al.  Dendritic cells and the control of immunity , 1998, Nature.

[24]  J. Altman,et al.  Initiation of signal transduction through the T cell receptor requires the multivalent engagement of peptide/MHC ligands [corrected]. , 1998, Immunity.

[25]  S. Bromley,et al.  A supramolecular basis for CD45 tyrosine phosphatase regulation in sustained T cell activation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Arup K Chakraborty,et al.  The Immunological Synapse Balances T Cell Receptor Signaling and Degradation , 2003, Science.

[27]  S. Bromley,et al.  The immunological synapse: a molecular machine controlling T cell activation. , 1999, Science.

[28]  S. Kassis,et al.  Direct visualization of redistribution and capping of fluorescent gangliosides on lymphocytes , 1984, The Journal of cell biology.

[29]  S. Singer,et al.  Polarization of the Golgi apparatus and the microtubule-organizing center within cloned natural killer cells bound to their targets. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Mark M Davis,et al.  Continuous T cell receptor signaling required for synapse maintenance and full effector potential , 2003, Nature Immunology.

[31]  Fanny Marhuenda,et al.  CONTACTS , 1967 .

[32]  Mark M Davis,et al.  Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. , 2002, Immunity.

[33]  Jianzhu Chen,et al.  Soluble peptide–MHC monomers cause activation of CD8+ T cells through transfer of the peptide to T cell MHC molecules , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[34]  J. Harty,et al.  CD8+ T cell effector mechanisms in resistance to infection. , 2000, Annual review of immunology.

[35]  A. Lanzavecchia,et al.  The duration of antigenic stimulation determines the fate of naive and effector T cells. , 1998, Immunity.

[36]  M. Davis,et al.  Differential clustering of CD4 and CD3zeta during T cell recognition. , 2000, Science.

[37]  D. Zaller,et al.  Staging and resetting T cell activation in SMACs , 2002, Nature Immunology.

[38]  Mark M. Davis,et al.  Costimulation and endogenous MHC ligands contribute to T cell recognition , 2002, Nature Immunology.

[39]  Mark M. Davis,et al.  Direct observation of ligand recognition by T cells , 2002, Nature.

[40]  Philippe Bousso,et al.  Dynamics of Thymocyte-Stromal Cell Interactions Visualized by Two-Photon Microscopy , 2002, Science.

[41]  Douglas S Kwon,et al.  DC-SIGN, a Dendritic Cell–Specific HIV-1-Binding Protein that Enhances trans-Infection of T Cells , 2000, Cell.

[42]  I. Mellman,et al.  Activation of Lysosomal Function During Dendritic Cell Maturation , 2003, Science.

[43]  Michael S. Kuhns,et al.  CTLA-4: new insights into its biological function and use in tumor immunotherapy , 2002, Nature Immunology.

[44]  R. Zaru,et al.  Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes , 2000, Current Biology.

[45]  J. Lippincott-Schwartz,et al.  ZAP-70 Association with T Cell Receptor ζ (TCRζ): Fluorescence Imaging of Dynamic Changes upon Cellular Stimulation , 1998, The Journal of cell biology.

[46]  E. Bröcker,et al.  Antigen presentation in extracellular matrix: interactions of T cells with dendritic cells are dynamic, short lived, and sequential. , 2000, Immunity.

[47]  J. Egen,et al.  Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse is regulated by TCR signal strength. , 2002, Immunity.

[48]  P. Baumgaertner,et al.  The β1 and β3 Integrins Promote T Cell Receptor-mediated Cytotoxic T Lymphocyte Activation* , 2003, Journal of Biological Chemistry.

[49]  A. Kupfer,et al.  TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact site. , 1998, Journal of immunology.

[50]  A. Lanzavecchia,et al.  T lymphocyte costimulation mediated by reorganization of membrane microdomains. , 1999, Science.

[51]  T. Zal,et al.  Inhibition of T cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. , 2002, Immunity.

[52]  M. Norcross,et al.  A synaptic basis for T-lymphocyte activation. , 1984, Annales d'immunologie.

[53]  S. Davis,et al.  The structure and ligand interactions of CD2: implications for T-cell function. , 1996, Immunology today.

[54]  A. Lanzavecchia,et al.  Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton , 1995, The Journal of experimental medicine.

[55]  Abraham Kupfer,et al.  TCR-Induced Transmembrane Signaling by Peptide/MHC Class II Via Associated Ig-α/β Dimers , 2001 .

[56]  J. Lippincott-Schwartz,et al.  Regulation of ZAP-70 Intracellular Localization: Visualization with the Green Fluorescent Protein , 1997, The Journal of experimental medicine.

[57]  H. Grey,et al.  The minimal number of class II MHC-antigen complexes needed for T cell activation. , 1990, Science.

[58]  A. Trautmann,et al.  Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium , 1994, Current Biology.

[59]  Z L Wan,et al.  Crystal structure of R-phycoerythrin from Polysiphonia urceolata at 2.8 A resolution. , 1996, Journal of molecular biology.

[60]  R. Zaru,et al.  Cutting Edge: T Lymphocyte Activation by Repeated Immunological Synapse Formation and Intermittent Signaling 1 , 2003, The Journal of Immunology.

[61]  Jay T. Groves,et al.  Synaptic pattern formation during cellular recognition , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[62]  Michael Loran Dustin,et al.  Making the T cell receptor go the distance: a topological view of T cell activation. , 1997, Immunity.

[63]  G. Griffiths,et al.  The immunological synapse of CTL contains a secretory domain and membrane bridges. , 2001, Immunity.

[64]  Mark J. Miller,et al.  Two-Photon Imaging of Lymphocyte Motility and Antigen Response in Intact Lymph Node , 2002, Science.

[65]  R. Germain,et al.  Dynamic Imaging of T Cell-Dendritic Cell Interactions in Lymph Nodes , 2002, Science.

[66]  D. McGavern,et al.  Molecular anatomy of antigen-specific CD8+ T cell engagement and synapse formation in vivo , 2002, Nature Immunology.

[67]  S. Singer,et al.  Cell biology of cytotoxic and helper T cell functions: immunofluorescence microscopic studies of single cells and cell couples. , 1989, Annual review of immunology.

[68]  D. Toomre,et al.  Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane , 2002, Nature.

[69]  Anjana Rao,et al.  Gene regulation mediated by calcium signals in T lymphocytes , 2001, Nature Immunology.

[70]  Michael Loran Dustin,et al.  T Cell Receptor Signaling Precedes Immunological Synapse Formation , 2002, Science.

[71]  M. Soloski,et al.  Physiological Regulation of the Immunological Synapse by Agrin , 2001, Science.

[72]  E. Ingulli,et al.  Cutting Edge: In Vivo Identification of TCR Redistribution and Polarized IL-2 Production by Naive CD4 T Cells1 , 2001, The Journal of Immunology.

[73]  H. Grey,et al.  The minimal number of antigen‐major histocompatibility complex class II complexes required for activation of naive and primed T cells , 1997, European journal of immunology.

[74]  J. Cochran,et al.  The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. , 2000, Immunity.

[75]  D. McDonald,et al.  Recruitment of HIV and Its Receptors to Dendritic Cell-T Cell Junctions , 2003, Science.

[76]  Takashi Saito,et al.  Dependence of T Cell Antigen Recognition on the Dimensions of an Accessory Receptor–Ligand Complex , 1999, The Journal of experimental medicine.

[77]  M. Davis,et al.  Visualizing the dynamics of T cell activation: intracellular adhesion molecule 1 migrates rapidly to the T cell/B cell interface and acts to sustain calcium levels. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[78]  Michael Loran Dustin,et al.  Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. , 2002, Immunity.

[79]  P. Negulescu,et al.  Polarity of T cell shape, motility, and sensitivity to antigen. , 1996, Immunity.

[80]  Tetsuo Yamazaki,et al.  T cell receptor ligation induces the formation of dynamically regulated signaling assemblies , 2002, The Journal of cell biology.