A new 1'-methylenedisulfide deoxyribose that forms an efficient cross-link to DNA cytosine-5 methyltransferase (DNMT).

A newly designed 1'-methylenedisulfide deoxyribose probe can efficiently cross-link to DNA cytosine-5-methyltransferases (DNMTs) through the active Cys residue, which provides a new tool to covalently trap DNMT-DNA complexes.