Psychological Effects of Cholinomimetic Agents

Janowsky, Davis and colleagues began in 1972 to explore the possibility that the affective disorders, mania and depression, might be due to a complex balance, or inter-action, between adrenergic and cholinergic factors (Janowsky et al., 1972a). Proposed most simply, mania was hypothesized to be a syndrome due to relatively diminished central acetylcholine (ACh) activity, compared to normal or increased noradrenergic and/or dopaminergic activity; and depression was proposed to be the converse (Janowsky et al., 1972b).

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