Angiopoietin-2 sensitizes endothelial cells to TNF-α and has a crucial role in the induction of inflammation

[1]  H. Augustin,et al.  The Tie-2 ligand Angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism , 2005, Journal of Cell Science.

[2]  G. Yancopoulos,et al.  Dysmorphogenesis of kidney cortical peritubular capillaries in angiopoietin-2-deficient mice. , 2004, The American journal of pathology.

[3]  Thomas Hartmann,et al.  Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2. , 2004, Cancer cell.

[4]  H. Augustin,et al.  The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. , 2004, Blood.

[5]  N. Yang,et al.  Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer. , 2003, Cancer research.

[6]  B. Jeon,et al.  Tie-ing the antiinflammatory effect of angiopoietin-1 to inhibition of NF-kappaB. , 2003, Circulation research.

[7]  Byeong HwaJeon,et al.  Tie-ing the Antiinflammatory Effect of Angiopoietin-1 to Inhibition of NF-κB , 2003 .

[8]  K. Alitalo,et al.  Angiopoietin-1 Protects Against the Development of Cardiac Allograft Arteriosclerosis , 2003, Circulation.

[9]  P. D’Amore,et al.  Getting Tie(2)d up in angiogenesis. , 2002, The Journal of clinical investigation.

[10]  P. Campochiaro,et al.  Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. , 2002, Developmental cell.

[11]  K. Preissner,et al.  Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes , 2002, Nature Medicine.

[12]  J. Tonn,et al.  Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2. , 2002, The Journal of clinical investigation.

[13]  J. Gamble,et al.  Angiopoietin-1 Is an Antipermeability and Anti-Inflammatory Agent In Vitro and Targets Cell Junctions , 2000, Circulation research.

[14]  N. Glazer,et al.  Angiopoietin-1 protects the adult vasculature against plasma leakage , 2000, Nature Medicine.

[15]  H. Augustin,et al.  Heterogeneity of angiogenesis and blood vessel maturation in human tumors: implications for antiangiogenic tumor therapies. , 2000, Cancer research.

[16]  Thomas N. Sato,et al.  Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. , 1999, Science.

[17]  K. Plate,et al.  Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. , 1998, The American journal of pathology.

[18]  C. Rüegg,et al.  Clinical applications of TNF-α in cancer , 1998 .

[19]  M. Menger,et al.  Characterization of Angiogenesis and Microcirculation of High–Grade Glioma: An Intravital Multifluorescence Microscopic Approach in the Athymic Nude Mouse , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[20]  M. Dewhirst,et al.  Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. , 1997, Circulation research.

[21]  Douglas Hanahan,et al.  Signaling Vascular Morphogenesis and Maintenance , 1997, Science.

[22]  Thomas N. Sato,et al.  Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. , 1997, Science.

[23]  Pamela F. Jones,et al.  Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning , 1996, Cell.

[24]  Pamela F. Jones,et al.  Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis , 1996, Cell.

[25]  L. Picker,et al.  Lymphocyte Homing and Homeostasis , 1996, Science.

[26]  J. Folkman,et al.  The role of angiogenesis in tumor growth. , 1992, Seminars in cancer biology.

[27]  J. Denekamp,et al.  Endothelial proliferation in tumours and normal tissues: continuous labelling studies. , 1984, British Journal of Cancer.

[28]  H. Lehr,et al.  Intravital fluorescence microscopy for the study of leukocyte interaction with platelets and endothelial cells. , 1999, Methods in enzymology.