Glucose administration combined with photodynamic therapy of cancer improves therapeutic efficacy

Both the scope and the levels of activity in basic research and in the clinical applications of PDT, have grown enormously during the past few years. Several studies have examined the synergism of hyperthermia and chemotherapeutic agents in combination with PDT to enhance tumor eradication. The present study investigates the synergism of glucose administration combined with phototherapy.

[1]  T J Dougherty,et al.  Identification of singlet oxygen as the cytotoxic agent in photoinactivation of a murine tumor. , 1976, Cancer research.

[2]  W. Star,et al.  Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers. , 1986, Cancer research.

[3]  R. Jain,et al.  Effect of glucose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats. , 1986, Cancer research.

[4]  M W Berns,et al.  Mechanism of tumor destruction following photodynamic therapy with hematoporphyrin derivative, chlorin, and phthalocyanine. , 1988, Journal of the National Cancer Institute.

[5]  P. Okunieff,et al.  Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. , 1989, Cancer research.

[6]  A. Girotti,et al.  GLUCOSE ADMINISTRATION AUGMENTS IN VIVO UPTAKE AND PHOTOTOXICITY OF THE TUMOR‐LOCALIZING FRACTION OF HEMATOPORPHYRIN DERIVATIVE , 1989, Photochemistry and photobiology.

[7]  J. Kennedy,et al.  The possible role of ionic species in selective biodistribution of photochemotherapeutic agents toward neoplastic tissue. , 1990, Journal of photochemistry and photobiology. B, Biology.

[8]  M. Eden,et al.  The pH of rat tumors measured in vivo. , 1955, Journal of the National Cancer Institute.

[9]  T. Mang,et al.  Combination studies of hyperthermia induced by the neodymium: Yttrium‐Aluminum‐Garnet (Nd:YAG) laser as an adjuvant to photodynamic therapy , 1990, Lasers in surgery and medicine.

[10]  M. Berns,et al.  Potentiation of laser photoradiation therapy by chemotherapy. , 1985, Current surgery.

[11]  T. Dougherty,et al.  Potentiation of photodynamic therapy by heat: Effect of sequence and time interval between treatments in vivo , 1985, Lasers in surgery and medicine.

[12]  J. Hudson,et al.  EXCITED STATES OF FLAVINE COENZYMES‐III. FLUORESCENCE AND PHOSPHORESCENCE EMISSIONS , 1968 .

[13]  M. Berns,et al.  Use of multiple photosensitizers and wavelengths during photodynamic therapy: a new approach to enhance tumor eradication. , 1990, Journal of the National Cancer Institute.

[14]  M. Berns,et al.  Mechanism of tumor destruction in photodynamic therapy , 1987 .

[15]  R. Jain,et al.  Effect of galactose on systemic hemodynamics and blood flow rate in normal and tumor tissues in rats. , 1988, Cancer research.

[16]  T. Mukherjee,et al.  Triplet excited states and semiquinone radicals of 1,4-disubstituted anthraquinones , 1990 .

[17]  G. A. Alexander,et al.  Modification of human tumor pH by elevation of blood glucose. , 1987, International journal of radiation oncology, biology, physics.

[18]  R. Jain,et al.  Effect of glucose and galactose on microcirculatory flow in normal and neoplastic tissues in rabbits. , 1987, Cancer research.

[19]  S. Britton,et al.  Blood flow in transplantable bladder tumors treated with hematoporphyrin derivative and light. , 1984, Cancer research.

[20]  C. Gomer.  INTRODUCTION.: PHOTODYNAMIC THERAPY , 1987 .

[21]  M. Berns,et al.  TUMOR DESTRUCTION IN PHOTODYNAMIC THERAPY , 1987, Photochemistry and photobiology.

[22]  E. Jähde,et al.  Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues. , 1982, Cancer research.

[23]  David Kessel,et al.  Photodynamic therapy of neoplastic disease , 1990 .

[24]  M. Urano,et al.  Effect of thermochemotherapy (combined cyclophosphamide and hyperthermia) given at various temperatures with or without glucose administration on a murine fibrosarcoma. , 1985, Cancer research.

[25]  B. Tromberg,et al.  In vivo TUMOR OXYGEN TENSION MEASUREMENTS FOR THE EVALUATION OF THE EFFICIENCY OF PHOTODYNAMIC THERAPY , 1990, Photochemistry and photobiology.