Biomimetic Approaches Employing the Ugi Five-Center Four-Component Reaction for Synthesis of the Right-Hand Portion of Halichonadin Q and the Central Part of Halichonadin M

Abstract One-pot syntheses of models of the right-hand portion and the central part of the respective structures of halichonadins Q and M, using the Ugi five-center four-component reaction (U-5C-4CR), were executed. The biomimetic strategy employed in these routes demonstrates the feasibility of pathways we have proposed for the biosynthesis of marine organisms.