An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016

ABSTRACT The Inaugural Symposium on Childhood Cancer Health Disparities was held in Houston, Texas, on November 2, 2016. The symposium was attended by 109 scientists and clinicians from diverse disciplinary backgrounds with interests in pediatric cancer disparities and focused on reviewing our current knowledge of disparities in cancer risk and outcomes for select childhood cancers. Following a full day of topical sessions, everyone participated in a brainstorming session to develop a working strategy for the continued expansion of research in this area. This meeting was designed to serve as a springboard for examination of childhood cancer disparities from a more unified and systematic approach and to enhance awareness of this area of need.

[1]  Aditya M. Deshpande,et al.  Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia , 2017, Pediatric blood & cancer.

[2]  K. Reinier,et al.  A task‐based assessment of parental occupational exposure to pesticides and childhood acute lymphoblastic leukemia , 2017, Environmental research.

[3]  E. Delwart,et al.  In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. , 2017, Blood.

[4]  C. Rodríguez-Galindo,et al.  Socioeconomic status and global variations in the incidence of neuroblastoma: call for support of population‐based cancer registries in low‐middle–income countries , 2017, Pediatric blood & cancer.

[5]  A. Seif,et al.  The role of acuity of illness at presentation in early mortality in black children with acute myeloid leukemia , 2017, American journal of hematology.

[6]  J. Khan,et al.  Frequent inactivating germline mutations in DNA repair genes in patients with Ewing sarcoma Germline mutations in Ewing sarcoma , 2016, Genetics in Medicine.

[7]  A. Seif,et al.  Low rates of pregnancy screening in adolescents before teratogenic exposures in a national sample of children's hospitals , 2016, Cancer.

[8]  K. Reinier,et al.  A task-based assessment of parental occupational exposure to organic solvents and other compounds and the risk of childhood leukemia in California. , 2016, Environmental research.

[9]  M. Pombo-de-Oliveira,et al.  Early-age Acute Leukemia: Revisiting Two Decades of the Brazilian Collaborative Study Group. , 2016, Archives of medical research.

[10]  M. Alderfer,et al.  Socioeconomic status (SES) and childhood acute myeloid leukemia (AML) mortality risk: Analysis of SEER data. , 2016, Cancer epidemiology.

[11]  L. Elting,et al.  Health disparities and impact on outcomes in children with primary central nervous system solid tumors. , 2016, Journal of neurosurgery. Pediatrics.

[12]  S. Selvin,et al.  Systematic Reviews and Meta- and Pooled Analyses Parental Tobacco Smoking and Acute Myeloid Leukemia The Childhood Leukemia International Consortium , 2016 .

[13]  L. Elting,et al.  Health Disparities Influence Childhood Melanoma Stage at Diagnosis and Outcome. , 2016, The Journal of pediatrics.

[14]  S. Plon,et al.  Shorter Remission Telomere Length Predicts Delayed Neutrophil Recovery After Acute Myeloid Leukemia Therapy: A Report From the Children's Oncology Group. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  B. Ritz,et al.  Risk of Childhood Cancer by Maternal Birthplace: A Test of the Hispanic Paradox. , 2016, JAMA pediatrics.

[16]  Traci M. Blonquist,et al.  Impact of Socioeconomic Status on Timing of Relapse and Overall Survival for Children Treated on Dana‐Farber Cancer Institute ALL Consortium Protocols (2000–2010) , 2016, Pediatric blood & cancer.

[17]  O. Delattre,et al.  Cooperation between somatic mutations and germline susceptibility variants in tumorigenesis – a dangerous liaison , 2016, Molecular & cellular oncology.

[18]  U. Hofmann,et al.  NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity , 2016, Nature Genetics.

[19]  Nerissa S. Bauer,et al.  Poverty and Child Health in the United States , 2016, Pediatrics.

[20]  L. DeCamp,et al.  The “Battle” of Managing Language Barriers in Health Care , 2016, Clinical pediatrics.

[21]  H. Hansen,et al.  A Functional Polymorphism in the CEBPE Gene Promoter Influences Acute Lymphoblastic Leukemia Risk through Interaction with the Hematopoietic Transcription Factor Ikaros , 2015, Leukemia.

[22]  W. Pelletier,et al.  Assessment of Financial Burden as a Standard of Care in Pediatric Oncology , 2015, Pediatric blood & cancer.

[23]  C. Rodríguez-Galindo,et al.  Ethnic, Racial, and Socioeconomic Disparities in Retinoblastoma. , 2015, JAMA pediatrics.

[24]  A. Seif,et al.  Merging Children’s Oncology Group Data with an External Administrative Database Using Indirect Patient Identifiers: A Report from the Children’s Oncology Group , 2015, PloS one.

[25]  J. Eckel-Passow,et al.  A Heritable Missense Polymorphism in CDKN2A Confers Strong Risk of Childhood Acute Lymphoblastic Leukemia and Is Preferentially Selected during Clonal Evolution. , 2015, Cancer research.

[26]  R. Keogh,et al.  Racial/ethnic and socioeconomic disparities in survival among children with acute lymphoblastic leukemia in California, 1988–2011: A population‐based observational study , 2015, Pediatric blood & cancer.

[27]  R. Keren,et al.  Comparison of in‐patient costs for children treated on the AAML0531 clinical trial: A report from the Children's Oncology Group , 2015, Pediatric blood & cancer.

[28]  S. Chanock,et al.  Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite , 2015, Nature Genetics.

[29]  S. Gahagan,et al.  Participation in pediatric oncology research protocols: Racial/ethnic, language and age‐based disparities , 2015, Pediatric blood & cancer.

[30]  A. Troxel,et al.  Comparison of administrative/billing data to expected protocol‐mandated chemotherapy exposure in children with acute myeloid leukemia: A report from the Children's Oncology Group , 2015, Pediatric blood & cancer.

[31]  M. Pombo-de-Oliveira,et al.  Polymorphisms in CYP1B1, CYP3A5, GSTT1, and SULT1A1 Are Associated with Early Age Acute Leukemia , 2015, PloS one.

[32]  W. Gauderman,et al.  Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011. , 2015, Blood.

[33]  A. Rosenberg,et al.  Insurance status and risk of cancer mortality among adolescents and young adults , 2015, Cancer.

[34]  A. Seif,et al.  Dexrazoxane exposure and risk of secondary acute myeloid leukemia in pediatric oncology patients , 2015, Pediatric blood & cancer.

[35]  H. Adami,et al.  Socioeconomic disparities in survival from childhood leukemia in the United States and globally: a meta-analysis. , 2015, Annals of oncology : official journal of the European Society for Medical Oncology.

[36]  G. Abel,et al.  Prevalence and impact of financial hardship among New England pediatric stem cell transplantation families. , 2015, Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.

[37]  B. Mitchell,et al.  How Do Differences in Treatment Impact Racial and Ethnic Disparities in Acute Myeloid Leukemia? , 2015, Cancer Epidemiology, Biomarkers & Prevention.

[38]  M. Relling,et al.  Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[39]  M. Vinceti,et al.  A Review and Meta-Analysis of Outdoor Air Pollution and Risk of Childhood Leukemia , 2015, Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews.

[40]  L. Elting,et al.  Health disparities are important determinants of outcome for children with solid tumor malignancies. , 2015, Journal of pediatric surgery.

[41]  M. Fluchel,et al.  Financial Burden of Pediatric Cancer for Patients and Their Families. , 2015, Journal of oncology practice.

[42]  S. Gupta,et al.  Socioeconomic status and event free survival in pediatric acute lymphoblastic leukemia: a population-based cohort study. , 2014, Leukemia research.

[43]  G. Stoddard,et al.  Geography and the burden of care in pediatric cancers , 2014, Pediatric blood & cancer.

[44]  M. Relling,et al.  6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children's Oncology Group study. , 2014, Blood.

[45]  A. Seif,et al.  Association of weekend admission with hospital length of stay, time to chemotherapy, and risk for respiratory failure in pediatric patients with newly diagnosed leukemia at freestanding US children's hospitals. , 2014, JAMA pediatrics.

[46]  L. Jorde,et al.  Clinical and Biochemical Function of Polymorphic NR0B1 GGAA-Microsatellites in Ewing Sarcoma: A Report from the Children's Oncology Group , 2014, PloS one.

[47]  A. Chokkalingam,et al.  The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. , 2014, Blood.

[48]  R. Berg,et al.  Outcome of Pediatric Acute Myeloid Leukemia Patients Receiving Intensive Care in the United States , 2014, Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.

[49]  M. Loh,et al.  Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse , 2013, Nature Genetics.

[50]  B. Ritz,et al.  Prenatal exposure to traffic-related air pollution and risk of early childhood cancers. , 2013, American journal of epidemiology.

[51]  A. Chokkalingam,et al.  Novel childhood ALL susceptibility locus BMI1-PIP4K2A is specifically associated with the hyperdiploid subtype. , 2013, Blood.

[52]  M. Loh,et al.  Associations between genome-wide Native American ancestry, known risk alleles and B-cell ALL risk in Hispanic children , 2013, Leukemia.

[53]  Jun Wu,et al.  Abstract 2531: Childhood cancer and traffic-related air pollution exposure in pregnancy and early life. , 2013 .

[54]  S. Koifman,et al.  In Utero Pesticide Exposure and Leukemia in Brazilian Children < 2 Years of Age , 2012, Environmental health perspectives.

[55]  A. Ziogas,et al.  Association between insurance and socioeconomic status and risk of advanced stage Hodgkin lymphoma in adolescents and young adults , 2012, Cancer.

[56]  S. Koifman,et al.  Pregnancy, Maternal Tobacco Smoking, and Early Age Leukemia in Brazil , 2012, Front. Oncol..

[57]  G. Flores,et al.  Errors of medical interpretation and their potential clinical consequences: a comparison of professional versus ad hoc versus no interpreters. , 2012, Annals of emergency medicine.

[58]  Stephen L. Lessnick,et al.  Microsatellites with Macro-Influence in Ewing Sarcoma , 2012, Genes.

[59]  M. Relling,et al.  Nonadherence to oral mercaptopurine and risk of relapse in Hispanic and non-Hispanic white children with acute lymphoblastic leukemia: a report from the children's oncology group. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[60]  M. Loh,et al.  ARID5B genetic polymorphisms contribute to racial disparities in the incidence and treatment outcome of childhood acute lymphoblastic leukemia. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[61]  T. Lightfoot,et al.  Survival from childhood acute lymphoblastic leukaemia: the impact of social inequality in the United Kingdom. , 2012, European journal of cancer.

[62]  J. Wolfe,et al.  Massachusetts' Pediatric Palliative Care Network: successful implementation of a novel state-funded pediatric palliative care program. , 2011, Journal of palliative medicine.

[63]  M. Loh,et al.  Ancestry and pharmacogenomics of relapse in acute lymphoblastic leukemia , 2011, Nature Genetics.

[64]  V. Jobanputra,et al.  Prenatal PAH exposure is associated with chromosome-specific aberrations in cord blood. , 2010, Mutation research.

[65]  Kimberly J. Johnson,et al.  Childhood cancer in relation to parental race and ethnicity , 2010, Cancer.

[66]  P. Kaatsch Epidemiology of childhood cancer. , 2010, Cancer treatment reviews.

[67]  James Allan,et al.  Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk , 2010, Nature Genetics.

[68]  L. Cannon-Albright,et al.  Is There a Predisposition Gene for Ewing's Sarcoma? , 2010, Journal of oncology.

[69]  P. Buffler,et al.  This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License , 2009 .

[70]  J. Neuhaus,et al.  Ethnic and racial differences in patients with Ewing sarcoma , 2010, Cancer.

[71]  S. Lessnick,et al.  GSTM4 is a microsatellite-containing EWS/FLI target involved in Ewing's sarcoma oncogenesis and therapeutic resistance , 2009, Oncogene.

[72]  Ching-Hon Pui,et al.  Germline genomic variants associated with childhood acute lymphoblastic leukemia , 2009, Nature Genetics.

[73]  E. Papaemmanuil,et al.  Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia , 2009, Nature Genetics.

[74]  A. D. Diez Roux,et al.  Race/ethnicity and telomere length in the Multi‐Ethnic Study of Atherosclerosis , 2009, Aging cell.

[75]  J. Holl,et al.  Material hardship and the physical health of school-aged children in low-income households. , 2009, American journal of public health.

[76]  D. Zmirou-Navier,et al.  Traffic-Related Air Pollution and Socioeconomic Status: A Spatial Autocorrelation Study to Assess Environmental Equity on a Small-Area Scale , 2009, Epidemiology.

[77]  S. Lessnick,et al.  Microsatellites are EWS/FLI response elements: Genomic "junk" is EWS/FLI's treasure , 2008, Cell cycle.

[78]  Stephen C. Haroldsen,et al.  Microsatellites as EWS/FLI response elements in Ewing's sarcoma , 2008, Proceedings of the National Academy of Sciences.

[79]  J. Cook,et al.  Food Security, Poverty, and Human Development in the United States , 2008, Annals of the New York Academy of Sciences.

[80]  M. Levetown Communicating With Children and Families: From Everyday Interactions to Skill in Conveying Distressing Information , 2008, Pediatrics.

[81]  P. Upton,et al.  Costs of caring for a child with cancer: a questionnaire survey. , 2007, Child: care, health and development.

[82]  S. Koifman,et al.  Infant Acute Leukemia and Maternal Exposures during Pregnancy , 2006, Cancer Epidemiology Biomarkers & Prevention.

[83]  S. Meshinchi,et al.  Ethnicity and survival in childhood acute myeloid leukemia: a report from the Children's Oncology Group. , 2006, Blood.

[84]  M. Loh,et al.  Ethnic Difference in Daycare Attendance, Early Infections, and Risk of Childhood Acute Lymphoblastic Leukemia , 2005, Cancer Epidemiology Biomarkers & Prevention.

[85]  Gail M. Williams,et al.  Hernias and Ewing's sarcoma family of tumours: a pooled analysis and meta-analysis. , 2005, The Lancet. Oncology.

[86]  M. Nord,et al.  Food insecurity is associated with adverse health outcomes among human infants and toddlers. , 2004, The Journal of nutrition.

[87]  B. Zuckerman,et al.  Errors in medical interpretation and their potential clinical consequences in pediatric encounters. , 2003, Pediatrics.

[88]  J. Roganovic,et al.  Epidemiology of childhood cancer. , 1999, IARC scientific publications.

[89]  K Wheatley,et al.  The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. , 1998, Blood.

[90]  P. Pizzo,et al.  Principles and Practice of Pediatric Oncology , 1989 .

[91]  Adolph E. Christ,et al.  Childhood Cancer , 2020, The Downstate Series of Research in Psychiatry and Psychology.

[92]  A. Cabrera,et al.  EWING'S SARCOMA. , 1964, Surgery, gynecology & obstetrics.