Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.

[1]  J. Chen,et al.  Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists. , 2005, Bioorganic & medicinal chemistry letters.

[2]  P. Soubrié,et al.  Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[3]  A. Izzo,et al.  Cannabinoids for gastrointestinal diseases: potential therapeutic applications , 2003, Expert opinion on investigational drugs.

[4]  K. Flegal,et al.  Prevalence and trends in obesity among US adults, 1999-2000. , 2002, JAMA.

[5]  Á. Pazos,et al.  Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain. , 2002, European journal of pharmacology.

[6]  William J Welsh,et al.  Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor. , 2002, Journal of medicinal chemistry.

[7]  R. Pertwee Cannabinoid receptor ligands: clinical and neuropharmacological considerations, relevant to future drug discovery and development , 2000, Expert opinion on investigational drugs.

[8]  M. Rinaldi-Carmona,et al.  The development of cannabinoid antagonists. , 1999, Current medicinal chemistry.

[9]  John C. Lee,et al.  Chapter 20. Pharmacology of Cannabinoid Receptor Agonists and Antagonists , 1999 .

[10]  P. Casellas,et al.  A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1 , 1997, The Journal of Biological Chemistry.

[11]  R. Pertwee Pharmacology of cannabinoid CB1 and CB2 receptors. , 1997, Pharmacology & therapeutics.

[12]  K. Mackie,et al.  Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. , 1995, Molecular pharmacology.

[13]  Chang Kiu Lee,et al.  Condensation reactions of aryl acyloins with ureas in ethylene glycol , 1994 .

[14]  P. Soubrié,et al.  SR141716A, a potent and selective antagonist of the brain cannabinoid receptor , 1994, FEBS letters.

[15]  M. Johnson,et al.  Enhancement of brain [3H]flunitrazepam binding and analgesic activity of synthetic cannabimimetics. , 1985, European journal of pharmacology.

[16]  I. I. Brekhman,et al.  Effect of eleutherococcus on alarm-phase of stress. , 1969, Life sciences.

[17]  R. Gompper,et al.  Formamid‐Reaktionen, XII. Alkylierungs‐ und Acylierungsreaktionen an Formamid: Tris‐formylamino‐methan , 1959 .