The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies
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J. Silvio Gutkind | Martin C. Abba | Yardena Samuels | Y. Samuels | Zhiyong Wang | J. S. Gutkind | A. Molinolo | M. Abba | Zhiyong Wang | Alfredo A. Molinolo | Daniel Martin | L. Vitale-Cross | M. Zaida | N. Delic | J. G. Lyons | Daniel Martin | J. Guy Lyons | Lynn Vitale-Cross | Moraima Zaida | Naomi C. Delic | Moraima Zaida | J. Gutkind
[1] A. Giuliano,et al. HEAD AND NECK SQUAMOUS CELL CANCER AND THE HUMAN PAPILLOMAVIRUS: SUMMARY OF A NATIONAL CANCER INSTITUTE STATE OF THE SCIENCE MEETING, , 2009 .
[2] A. Cuddihy,et al. The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-alpha. , 1999, Oncogene.
[3] Heather L. Mulder,et al. The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes , 2014, Nature Communications.
[4] H. Ohtsuki,et al. Accumulation of driver and passenger mutations during tumor progression , 2009, Proceedings of the National Academy of Sciences.
[5] J. Manola,et al. TP53 mutations and survival in squamous-cell carcinoma of the head and neck. , 2007, The New England journal of medicine.
[6] G. Peters,et al. Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS. , 2009, Genes & development.
[7] R. Beart,et al. Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. , 1995, Cancer research.
[8] D. Wong,et al. Dissecting the Akt/Mammalian Target of Rapamycin Signaling Network: Emerging Results from the Head and Neck Cancer Tissue Array Initiative , 2007, Clinical Cancer Research.
[9] E. Sausville,et al. Mammalian target of rapamycin, a molecular target in squamous cell carcinomas of the head and neck. , 2005, Cancer research.
[10] Giacomo Cavalli,et al. Trithorax group proteins: switching genes on and keeping them active , 2011, Nature Reviews Molecular Cell Biology.
[11] A. Cuddihy,et al. The human papilloma virus (HPV)-18 E6 oncoprotein physically associates with Tyk2 and impairs Jak-STAT activation by interferon-α , 1999, Oncogene.
[12] J. Myers,et al. Xenograft models of head and neck cancers , 2009, Head & neck oncology.
[13] Michael J. Ziller,et al. Transcriptional and Epigenetic Dynamics during Specification of Human Embryonic Stem Cells , 2013, Cell.
[14] N. Dubrawsky. Cancer statistics , 1989, CA: a cancer journal for clinicians.
[15] Pornpimol Charoentong,et al. ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks , 2009, Bioinform..
[16] C. Van Waes,et al. Role of activated nuclear factor‐κB in the pathogenesis and therapy of squamous cell carcinoma of the head and neck , 2007, Head & neck.
[17] M. Dawson,et al. Cancer Epigenetics: From Mechanism to Therapy , 2012, Cell.
[18] Y. Mitsuishi,et al. The Keap1–Nrf2 system in cancers: stress response and anabolic metabolism , 2012, Front. Oncol..
[19] Malini Guha. Blockbuster dreams for Pfizer's CDK inhibitor , 2013, Nature Biotechnology.
[20] S A Forbes,et al. The Catalogue of Somatic Mutations in Cancer (COSMIC) , 2008, Current protocols in human genetics.
[21] Ruud H. Brakenhoff,et al. The molecular biology of head and neck cancer , 2011, Nature Reviews Cancer.
[22] Levi A Garraway,et al. Genomic Analysis of Head and Neck Squamous Cell Carcinoma Cell Lines and Human Tumors: A Rational Approach to Preclinical Model Selection , 2014, Molecular Cancer Research.
[23] J. Herman,et al. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[24] A I Saeed,et al. TM4: a free, open-source system for microarray data management and analysis. , 2003, BioTechniques.
[25] Takafumi Suzuki,et al. Roles of Keap1–Nrf2 System in Upper Aerodigestive Tract Carcinogenesis , 2012, Cancer Prevention Research.
[26] Mei Zhao,et al. Disruptive TP53 Mutation Is Associated with Aggressive Disease Characteristics in an Orthotopic Murine Model of Oral Tongue Cancer , 2011, Clinical Cancer Research.
[27] P. Pandolfi,et al. Role of the proto-oncogene Pokemon in cellular transformation and ARF repression , 2005, Nature.
[28] D. Sidransky,et al. Head and Neck Cancer in CNonsmokers: A Distinct Clinical and Molecular Entity , 1999, The Laryngoscope.
[29] P. Meltzer,et al. The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology. , 2013, Cancer research.
[30] E. K. Parkinson,et al. Dysregulated TGF-β1-induced Smad signalling occurs as a result of defects in multiple components of the TGF-β signalling pathway in human head and neck carcinoma cell lines , 2006 .
[31] L. Liau,et al. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation , 2013, Nature Genetics.
[32] P. Harari,et al. Enhanced radiation sensitivity in HPV-positive head and neck cancer. , 2013, Cancer research.
[33] Rajiv Sarin,et al. Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups , 2013, Nature Communications.
[34] S. Hewitt,et al. mTOR as a Molecular Target in HPV-Associated Oral and Cervical Squamous Carcinomas , 2012, Clinical Cancer Research.
[35] M. DePristo,et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data , 2011, Nature Genetics.
[36] R. Derynck,et al. Receptor-associated Mad homologues synergize as effectors of the TGF-β response , 1996, Nature.
[37] G. Clayman,et al. Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation , 2003, Oncogene.
[38] M. Soda,et al. Cancer‐associated missense mutations of caspase‐8 activate nuclear factor‐κB signaling , 2013, Cancer science.
[39] Adam A. Margolin,et al. The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.
[40] Mei Zhao,et al. Assembly and Initial Characterization of a Panel of 85 Genomically Validated Cell Lines from Diverse Head and Neck Tumor Sites , 2011, Clinical Cancer Research.
[41] D. Crowe,et al. Role of microRNA-138 as a potential tumor suppressor in head and neck squamous cell carcinoma. , 2013, International review of cell and molecular biology.
[42] R. Javier. Cell polarity proteins: common targets for tumorigenic human viruses , 2008, Oncogene.
[43] V. Mieulet,et al. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. , 2007, The Biochemical journal.
[44] E. K. Parkinson,et al. Dysregulated TGF-beta1-induced Smad signalling occurs as a result of defects in multiple components of the TGF-beta signalling pathway in human head and neck carcinoma cell lines. , 2006, International Journal of Oncology.
[45] K. Nakashiro,et al. Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin. , 2011, Oncology reports.
[46] T. Wong,et al. Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling , 2008, International journal of cancer.
[47] Avi Ma'ayan,et al. Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool , 2013, BMC Bioinformatics.
[48] P. Blanchard,et al. Treatment de‐escalation in HPV‐positive oropharyngeal carcinoma: Ongoing trials, critical issues and perspectives , 2015, International journal of cancer.
[49] D. Hayes,et al. The Cancer Genome Atlas: Integrated analysis of genome alterations in squamous cell carcinoma of the head and neck. , 2013 .
[50] J. Massagué,et al. Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus , 2003, Cell.
[51] D. Sidransky,et al. Immunohistochemical detection of p53 protein accumulation in head and neck cancer: correlation with p53 gene alterations. , 1999, Human pathology.
[52] C. Meijer,et al. Integrated human papillomavirus type 16 and loss of heterozygosity at 11q22 and 18q21 in an oral carcinoma and its derivative cell line. , 1995, Cancer research.
[53] T. Veldman,et al. Human papillomavirus E6 and Myc proteins associate in vivo and bind to and cooperatively activate the telomerase reverse transcriptase promoter , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[54] J. Brugge,et al. Outgrowth of Single Oncogene-expressing Cells from Suppressive Epithelial Environments , 2012, Nature.
[55] A. Shahangian,et al. Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response , 2006, Nature.
[56] R. Derynck,et al. Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. , 1996, Nature.
[57] S. Warnakulasuriya. Causes of oral cancer – an appraisal of controversies , 2009, BDJ.
[58] J. Tschopp,et al. Induction of TNF Receptor I-Mediated Apoptosis via Two Sequential Signaling Complexes , 2003, Cell.
[59] D. Pehlivan,et al. Involvement of EphA2 in head and neck squamous cell carcinoma: mRNA expression, loss of heterozygosity and immunohistochemical studies. , 2008, Oncology reports.
[60] Zhiyong Wang,et al. mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations , 2014, Journal of the National Cancer Institute.
[61] R. Gibbs,et al. Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. , 2013, Cancer discovery.
[62] J. Miller,et al. Predicting the Functional Effect of Amino Acid Substitutions and Indels , 2012, PloS one.
[63] Kevin Fung,et al. Frequent mutations in TP53 and CDKN2A found by next-generation sequencing of head and neck cancer cell lines. , 2012, Archives of otolaryngology--head & neck surgery.
[64] D. Hanahan,et al. Hallmarks of Cancer: The Next Generation , 2011, Cell.
[65] Serban Nacu,et al. Fast and SNP-tolerant detection of complex variants and splicing in short reads , 2010, Bioinform..
[66] J. Gutkind,et al. Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets. , 2013, Cancer discovery.
[67] H. Hakonarson,et al. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.
[68] R. Ferris,et al. Human papillomavirus-16 associated squamous cell carcinoma of the head and neck (SCCHN): a natural disease model provides insights into viral carcinogenesis. , 2005, European journal of cancer.
[69] A. McKenna,et al. The Mutational Landscape of Head and Neck Squamous Cell Carcinoma , 2011, Science.
[70] A. Jemal,et al. Cancer statistics, 2014 , 2014, CA: a cancer journal for clinicians.
[71] T. Sasagawa,et al. A new PCR-based assay amplifies the E6-E7 genes of most mucosal human papillomaviruses (HPV). , 2000, Virus research.
[72] Christine H Chung,et al. Human Papillomavirus in Head and Neck Cancer: Its Role in Pathogenesis and Clinical Implications , 2009, Clinical Cancer Research.
[73] K. Cornetta,et al. Aberrant expression of the myeloid zinc finger gene, MZF-1, is oncogenic. , 1995, Cancer research.
[74] R. Lotan,et al. DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma. , 1996, Cancer research.
[75] D. Sidransky,et al. Head and neck cancer. , 2001, The New England journal of medicine.
[76] Simion I. Chiosea,et al. Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers. , 2013, Cancer discovery.
[77] J Silvio Gutkind,et al. Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer. , 2011, Cancer research.
[78] J. Massagué,et al. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. , 2003, Cell.
[79] Esther Kim,et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[80] R. Gibbs,et al. Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 , 2011, Science.
[81] R. Campbell,et al. Cancer epigenetics drug discovery and development: the challenge of hitting the mark. , 2014, The Journal of clinical investigation.
[82] Mark D. Robinson,et al. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data , 2009, Bioinform..
[83] K. Münger,et al. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. , 1989, Science.