Noncontact broadband all-optical photoacoustic microscopy based on a low-coherence interferometer

We developed and fabricated a noncontact broadband all-optical photoacoustic microscopy (BD-AO-PAM) with a microchip laser and an all-fiber low coherence interferometer. Currently, the available detection bandwidth of the BD-AO-PAM is 67 MHz, and the lateral resolution measured by carbon fibers reaches 11 μm. Furthermore, the imaging capability of the BD-AO-PAM was testified by imaging hairs embedded in scattering gel and in vivo blood vessels of a mouse ear. The experimental results demonstrate that the BD-AO-PAM can image the tissues with high spatial resolution in vivo, which can be used as portable noncontact PAM for biomedical applications.

[1]  Stefan A. Carp,et al.  Optoacoustic imaging using interferometric measurement of surface displacement , 2004 .

[2]  Hao Zhang,et al.  Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy , 2007 .

[3]  Lihong V. Wang.  Multiscale photoacoustic microscopy and computed tomography. , 2009, Nature photonics.

[4]  Lihong V. Wang,et al.  Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs , 2012, Science.

[5]  Matthew O'Donnell,et al.  Broadband all-optical ultrasound transducers , 2007 .

[6]  Jean-Pierre Monchalin,et al.  Non-contact photoacoustic tomography and ultrasonography for tissue imaging , 2011, Biomedical optics express.

[7]  Sridhar Krishnaswamy,et al.  Heterodyne interferometer with two‐wave mixing in photorefractive crystals for ultrasound detection on rough surfaces , 1996 .

[8]  Da Xing,et al.  Functional imaging of cerebrovascular activities in small animals using high-resolution photoacoustic tomography. , 2007, Medical physics.

[9]  M. Paul,et al.  Interferometric detection of ultrasound at rough surfaces using optical phase conjugation , 1987 .

[10]  A. Oraevsky,et al.  Laser optoacoustic imaging system for detection of breast cancer. , 2009, Journal of biomedical optics.

[11]  Ruikang K. Wang,et al.  Noncontact photoacoustic imaging achieved by using a low-coherence interferometer as the acoustic detector. , 2011, Optics letters.

[12]  Da Xing,et al.  In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation with multiwavelength photoacoustic microscopy. , 2012, Optics letters.

[13]  Markus Haltmeier,et al.  Photoacoustic tomography using a Mach-Zehnder interferometer as an acoustic line detector. , 2007, Applied optics.

[14]  Thomas Berer,et al.  Remote photoacoustic imaging on solid material using a two-wave mixing interferometer. , 2010, Optics letters.

[15]  R. Leitgeb,et al.  Intrasweep phase-sensitive optical coherence tomography for noncontact optical photoacoustic imaging. , 2012, Optics letters.

[16]  Jan Laufer,et al.  Backward-mode multiwavelength photoacoustic scanner using a planar Fabry-Perot polymer film ultrasound sensor for high-resolution three-dimensional imaging of biological tissues. , 2008, Applied optics.