Busulfan-induced senescence is dependent on ROS production upstream of the MAPK pathway.

[1]  Daohong Zhou,et al.  Busulfan Selectively Induces Cellular Senescence but Not Apoptosis in WI38 Fibroblasts via a p53-Independent but Extracellular Signal-Regulated Kinase-p38 Mitogen-Activated Protein Kinase-Dependent Mechanism , 2006, Journal of Pharmacology and Experimental Therapeutics.

[2]  L. Rochette,et al.  NADPH oxidases are in part responsible for increased cardiovascular superoxide production during aging. , 2006, Free radical biology & medicine.

[3]  V. Petrov,et al.  Angiotensin II-stimulated collagen production in cardiac fibroblasts is mediated by reactive oxygen species , 2006, Journal of hypertension.

[4]  Daohong Zhou,et al.  Hematopoietic Stem Cell Senescence and Long-Term Bone Marrow Injury , 2006, Cell cycle.

[5]  Yong Wang,et al.  Total body irradiation selectively induces murine hematopoietic stem cell senescence. , 2006, Blood.

[6]  Elias S. J. Arnér,et al.  Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds. , 2005, Free radical biology & medicine.

[7]  K. Krause,et al.  Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach , 2005, Experimental Gerontology.

[8]  J. Campisi.  Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors , 2005, Cell.

[9]  N. Sharpless.  Ink4a/Arf links senescence and aging , 2004, Experimental Gerontology.

[10]  S. Oikawa,et al.  DNA intrastrand cross‐link at the 5′‐GA‐3′ sequence formed by busulfan and its role in the cytotoxic effect , 2004, Cancer science.

[11]  T. Russo,et al.  Redox Control of Signal Transduction, Gene Expression and Cellular Senescence , 2004, Neurochemical Research.

[12]  Bai-Lin Wu,et al.  High Intensity ras Signaling Induces Premature Senescence by Activating p38 Pathway in Primary Human Fibroblasts* , 2004, Journal of Biological Chemistry.

[13]  Daohong Zhou,et al.  Ionizing radiation and busulfan induce premature senescence in murine bone marrow hematopoietic cells. , 2003, Cancer research.

[14]  T. Tsuji,et al.  Bleomycin induces cellular senescence in alveolar epithelial cells , 2003, European Respiratory Journal.

[15]  Masashi Narita,et al.  Reversal of human cellular senescence: roles of the p53 and p16 pathways , 2003, The EMBO journal.

[16]  Jiahuai Han,et al.  Mitogen‐activated protein kinase p38 defines the common senescence‐signalling pathway , 2003, Genes to cells : devoted to molecular & cellular mechanisms.

[17]  M. Torres.  Mitogen-activated protein kinase pathways in redox signaling. , 2003, Frontiers in bioscience : a journal and virtual library.

[18]  M. Ahmad,et al.  Molecular mechanisms of N-acetylcysteine actions , 2003, Cellular and Molecular Life Sciences CMLS.

[19]  J. Brenton,et al.  Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence. , 2002, Cancer Research.

[20]  M. Edgren,et al.  The effect of modulation of glutathione cellular content on busulphan-induced cytotoxicity on hematopoietic cells in vitro and in vivo , 2002, Bone Marrow Transplantation.

[21]  N. Holbrook,et al.  Cellular response to oxidative stress: Signaling for suicide and survival * , 2002, Journal of cellular physiology.

[22]  Shuang Huang,et al.  Sequential Activation of the MEK-Extracellular Signal-Regulated Kinase and MKK3/6-p38 Mitogen-Activated Protein Kinase Pathways Mediates Oncogenic ras-Induced Premature Senescence , 2002, Molecular and Cellular Biology.

[23]  E. Hellström-Lindberg,et al.  The pharmacodynamic effect of busulfan in the P39 myeloid cell line in vitro , 2001, Leukemia.

[24]  J. Shay,et al.  Hayflick, his limit, and cellular ageing , 2000, Nature Reviews Molecular Cell Biology.

[25]  P. Várnai,et al.  Identification of renox, an NAD(P)H oxidase in kidney. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[26]  L. DeLeve,et al.  Role of Oxidative Stress and Glutathione in Busulfan Toxicity in Cultured Murine Hepatocytes , 2000, Pharmacology.

[27]  P. Cohen,et al.  Specificity and mechanism of action of some commonly used protein kinase inhibitors. , 2000, The Biochemical journal.

[28]  S. Grant,et al.  Follicular dendritic cells protect malignant B cells from apoptosis induced by anti-Fas and antineoplastic agents. , 1999, Journal of immunology.

[29]  M V Chernov,et al.  A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. , 1999, Science.

[30]  D. Woods,et al.  Senescence of human fibroblasts induced by oncogenic Raf. , 1998, Genes & development.

[31]  Kelly Gs.  Clinical applications of N-acetylcysteine. , 1998 .

[32]  G. Kelly,et al.  Clinical applications of N-acetylcysteine. , 1998, Alternative medicine review : a journal of clinical therapeutic.

[33]  C Roskelley,et al.  A biomarker that identifies senescent human cells in culture and in aging skin in vivo. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[34]  D. Hedley,et al.  Evaluation of methods for measuring cellular glutathione content using flow cytometry. , 1994, Cytometry.

[35]  J. Szer,et al.  The toxicity of busulphan and cyclophosphamide as the preparative regimen for bone marrow transplantation , 1991, British journal of haematology.

[36]  M. Lohmann‐Matthes,et al.  A fast and easy method to determine the production of reactive oxygen intermediates by human and murine phagocytes using dihydrorhodamine 123. , 1990, Journal of immunological methods.

[37]  J. S. Wassom,et al.  Toxicological review of busulfan (Myleran). , 1986, Mutation research.

[38]  O. Griffith,et al.  Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. , 1980, Analytical biochemistry.

[39]  W. Tong,et al.  Crosslinking of DNA by busulfan. Formation of diguanyl derivatives. , 1980, Biochimica et biophysica acta.