CLINICALLY SPEAKING DermACELL : Human Acellular Dermal Matrix Allograft

Diabetes often causes ulcers on the feet of diabetic patients. A 56-year-old, insulindependent, diabetic woman presented to the wound care center with a Wagner grade 3 ulcer of the right heel. She reported a 3-week history of ulceration with moderate drainage and odor and had a history of ulceration and osteomyelitis in the contralateral limb. Rigorous wound care, including hospitalization; surgical incision and drainage; intravenous antibiotic drug therapy; vacuum-assisted therapy; and a new room temperature, sterile, human acellular dermal matrix graft were used to heal the wound, save her limb, and restore her activities of daily living. This case presentation involves alternative treatment of a diabetic foot ulcer with this new acellular dermal matrix, DermACELL. (J Am Podiatr Med Assoc 106(2): 133-137, 2016)

[1]  Giampietro Bertasi,et al.  Use of a novel acellular dermal matrix allograft to treat complex trauma wound: a case study. , 2014, International journal of burns and trauma.

[2]  John L Roussalis Novel use of an acellular dermal matrix allograft to treat a chronic scalp wound with bone exposure: a case study. , 2014, International journal of burns and trauma.

[3]  J. Bullocks,et al.  DermACELL: a novel and biocompatible acellular dermal matrix in tissue expander and implant-based breast reconstruction , 2014, European Journal of Plastic Surgery.

[4]  Christopher Vashi Clinical Outcomes for Breast Cancer Patients Undergoing Mastectomy and Reconstruction with Use of DermACELL, a Sterile, Room Temperature Acellular Dermal Matrix , 2014, Plastic surgery international.

[5]  A. Katz,et al.  Evaluation of Host Tissue Integration, Revascularization, and Cellular Infiltration Within Various Dermal Substrates , 2012, Annals of plastic surgery.

[6]  D. Wukich,et al.  Diabetic foot infections: current concept review , 2012, Diabetic foot & ankle.

[7]  Sean B. Bury,et al.  Acellular dermal matrix in the management of the burn patient. , 2011, Aesthetic surgery journal.

[8]  M. Moore Inactivation of enveloped and non-enveloped viruses on seeded human tissues by gamma irradiation , 2011, Cell and Tissue Banking.

[9]  M. Moore,et al.  Use of controlled low dose gamma irradiation to sterilize allograft tendons for ACL reconstruction: biomechanical and clinical perspective , 2011, Cell and Tissue Banking.

[10]  R. Wilkins Acellular dermal graft augmentation in quadriceps tendon rupture repair , 2010 .

[11]  S. Snyder,et al.  Arthroscopic GraftJacket repair of rotator cuff tears. , 2010, Journal of shoulder and elbow surgery.

[12]  H. Langstein,et al.  Acellular Dermis–Assisted Prosthetic Breast Reconstruction versus Complete Submuscular Coverage: A Head-to-Head Comparison of Outcomes , 2009, Plastic and reconstructive surgery.

[13]  C. Attinger,et al.  Use of Integra, a Bilayered Human Skin Equivalent, in the Treatment of Diabetic Foot Ulcers , 2009 .

[14]  Ryan T. Crews,et al.  Clinical effectiveness of an acellular dermal regenerative tissue matrix compared to standard wound management in healing diabetic foot ulcers: a prospective, randomised, multicentre study , 2009, International wound journal.

[15]  M. Wright,et al.  A Multicenter Study Involving the Use of a Human Acellular Dermal Regenerative Tissue Matrix for the Treatment of Diabetic Lower Extremity Wounds , 2008, Advances in Skin & Wound Care.

[16]  Daniel K. Lee Achilles tendon repair with acellular tissue graft augmentation in neglected ruptures. , 2007, The Journal of foot and ankle surgery : official publication of the American College of Foot and Ankle Surgeons.

[17]  R. Johannes,et al.  Adverse Outcomes From Hospital-Acquired Infection in Pennsylvania Cannot Be Attributed to Increased Risk on Admission , 2006, American journal of medical quality : the official journal of the American College of Medical Quality.

[18]  W. Zamboni,et al.  Evaluation of hyperbaric oxygen for diabetic wounds: a prospective study. , 1997, Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.

[19]  Shyi-gen Chen,et al.  Treatment of severe burn with DermACELL(®), an acellular dermal matrix. , 2012, International journal of burns and trauma.

[20]  J. W. Cavuoto,et al.  The evaluation and treatment of diabetic foot ulcers. , 1982, Journal of the American Podiatry Association.