Sweet sorghum (Sorghum bicolor) biomass, generated from biofuel production, as a reservoir of bioactive compounds for human health

................................................................................................................................... ii ACKNOWLEDGEMENTS ........................................................................................................... vi DEDICATION ............................................................................................................................. viii LIST OF TABLES ....................................................................................................................... xiii LIST OF FIGURES ..................................................................................................................... xiv CHAPTER 1: INTRODUCTION AND REVIEW OF LITERATURE ..........................................1 1.

[1]  A. Koller,et al.  PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes. , 2004, American journal of physiology. Heart and circulatory physiology.

[2]  M. S. Blois,et al.  Antioxidant Determinations by the Use of a Stable Free Radical , 1958, Nature.

[3]  J. Arthur,et al.  High-Fat Diet Alters Gene Expression in the Liver and Colon: Links to Increased Development of Aberrant Crypt Foci , 2012, Digestive Diseases and Sciences.

[4]  Y. Hayashi,et al.  Influence of high-fat diets on the occurrence of spontaneous uterine endometrial adenocarcinomas in rats. , 1995, Teratogenesis, carcinogenesis, and mutagenesis.

[5]  D. Giustarini,et al.  Biomarkers of oxidative damage in human disease. , 2006, Clinical chemistry.

[6]  D. Mcfadden,et al.  Dietary influence on pancreatic cancer growth by catechin and inositol hexaphosphate. , 2007, The Journal of surgical research.

[7]  Guang Hui Xie,et al.  Biomass yield and changes in chemical composition of sweet sorghum cultivars grown for biofuel. , 2009 .

[8]  Louis Vermeulen,et al.  Wnt activity defines colon cancer stem cells and is regulated by the microenvironment , 2010, Nature Cell Biology.

[9]  G. Botchkina.  Colon cancer stem cells--from basic to clinical application. , 2013, Cancer letters.

[10]  Chin-Lin Hsu,et al.  Effect of gallic acid on high fat diet-induced dyslipidaemia, hepatosteatosis and oxidative stress in rats. , 2007, The British journal of nutrition.

[11]  Chia-Chi Chuang,et al.  Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases. , 2011, Annual review of nutrition.

[12]  Shivendra V. Singh,et al.  Bioactive food components and cancer risk reduction , 2008, Journal of cellular biochemistry.

[13]  J. Ross,et al.  BIOAVAILABILITY, METABOLIC EFFECTS AND SAFETY , 2002 .

[14]  F. Khuri,et al.  Perspectives for cancer prevention with natural compounds. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[15]  S. Jang,et al.  Mulberry Fruit (Moris fructus) Extracts Induce Human Glioma Cell Death In Vitro Through ROS-Dependent Mitochondrial Pathway and Inhibits Glioma Tumor Growth In Vivo , 2010, Nutrition and cancer.

[16]  A. Linnemann,et al.  Uncommonly high levels of 3-deoxyanthocyanidins and antioxidant capacity in the leaf sheaths of dye sorghum. , 2011, Journal of agricultural and food chemistry.

[17]  M. Wicha,et al.  Implications of cancer stem cell theory for cancer chemoprevention by natural dietary compounds. , 2011, The Journal of nutritional biochemistry.

[18]  Sofianos Andrikopoulos,et al.  Evaluating the glucose tolerance test in mice. , 2008, American journal of physiology. Endocrinology and metabolism.

[19]  P. Allavena,et al.  Cancer-related inflammation , 2008, Nature.

[20]  D. Magnolato,et al.  Glucosylated flavonoids and other phenolic compounds from sorghum , 1986 .

[21]  G. Bolwell,et al.  Phenols in the plant and in man. The potential for possible nutritional enhancement of the diet by modifying the phenols content or profile , 2000 .

[22]  J. Thomson,et al.  Embryonic stem cell lines derived from human blastocysts. , 1998, Science.

[23]  Melissa Johnson,et al.  Sweet potato leaves: properties and synergistic interactions that promote health and prevent disease. , 2010, Nutrition reviews.

[24]  David Gottlieb,et al.  Mechanism of Action , 2012, Antibiotics.

[25]  M. Büchler,et al.  Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate. , 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

[26]  Huawei Zeng,et al.  Obesity‐related colon cancer: Dietary factors and their mechanisms of anticancer action ‡ , 2012, Clinical and experimental pharmacology & physiology.

[27]  R. Waniska,et al.  Effects of growth conditions on grain molding and phenols in sorghum caryopsis , 1989 .

[28]  S. Grundy.  Metabolic Syndrome Pandemic , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[29]  J. Awika,et al.  Comparative antioxidant, antiproliferative and phase II enzyme inducing potential of sorghum (Sorghum bicolor) varieties. , 2009 .

[30]  J. Milner.  Molecular targets for bioactive food components. , 2004, The Journal of nutrition.

[31]  I. Johnson,et al.  Anticarcinogenic effects of diet-related apoptosis in the colorectal mucosa. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[32]  L. Rooney,et al.  Phenolic compounds and antioxidant activity of sorghum grains of varying genotypes. , 2005, Journal of agricultural and food chemistry.

[33]  L. Giovannelli,et al.  Effect of 4-coumaric and 3,4-dihydroxybenzoic acid on oxidative DNA damage in rat colonic mucosa. , 2003, The British journal of nutrition.

[34]  C. McClain,et al.  Gut microbiota, intestinal permeability, obesity-induced inflammation, and liver injury. , 2011, JPEN. Journal of parenteral and enteral nutrition.

[35]  L. Butler,et al.  Tannin content as a function of grain maturity and drying conditions in several varieties of Sorghum bicolor (L.) Moench. , 1979, Journal of agricultural and food chemistry.

[36]  Tao Zhang,et al.  Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells , 2010, Clinical Cancer Research.

[37]  Benjamin Geiger,et al.  Down-Regulation of β-Catenin by Activated p53 , 2001, Molecular and Cellular Biology.

[38]  L. Rooney,et al.  Flavonoid composition of red sorghum genotypes , 2009 .

[39]  C. S. Yang,et al.  Inhibition of carcinogenesis by dietary polyphenolic compounds. , 2001, Annual review of nutrition.

[40]  M. Nam,et al.  Apigeninidin induces apoptosis through activation of Bak and Bax and subsequent mediation of mitochondrial damage in human promyelocytic leukemia HL-60 cells , 2012 .

[41]  K. Cha,et al.  The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. , 2007, Biological & pharmaceutical bulletin.

[42]  K Botzenhart,et al.  Reactive Oxygen Species , 2014 .

[43]  R. Jope,et al.  The glamour and gloom of glycogen synthase kinase-3. , 2004, Trends in biochemical sciences.

[44]  G. De Pergola,et al.  Obesity as a Major Risk Factor for Cancer , 2013, Journal of obesity.

[45]  B V S Reddy,et al.  Sweet sorghum: food, feed, fodder and fuel crop , 2006 .

[46]  L. Odama,et al.  Evaluation of toxicity profile of leaf base extract of Sorghum bicolor in rat. , 2009 .

[47]  Pablo Tamayo,et al.  CDK8 is a colorectal cancer oncogene that regulates β-catenin activity , 2008, Nature.

[48]  D. Parkin,et al.  Risk factors for cholangiocarcinoma in high-risk area of Thailand: role of lifestyle, diet and methylenetetrahydrofolate reductase polymorphisms. , 2012, Cancer epidemiology.

[49]  P. Puigserver,et al.  Resveratrol improves health and survival of mice on a high-calorie diet , 2006, Nature.

[50]  B. P. Yu,et al.  Cellular defenses against damage from reactive oxygen species. , 1994, Physiological reviews.

[51]  J. Pezzuto,et al.  Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells* , 1998, The Journal of Biological Chemistry.

[52]  N. Njongmeta.  Extractability Profiling and Antioxidant Activity of Flavonoids in Sorghum Grain and Non-grain Materials , 2009 .

[53]  Xin Lu,et al.  Live or let die: the cell's response to p53 , 2002, Nature Reviews Cancer.

[54]  F. E. Sikwese.  Sorghum phenolic extracts : their storage stability and antioxidant activity in sunflower oil , 2008 .

[55]  M. Ishikawa,et al.  Inhibitory effects of naringenin on tumor growth in human cancer cell lines and sarcoma S-180-implanted mice. , 2005, Biological & pharmaceutical bulletin.

[56]  R. Burcelin,et al.  Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice. , 2009, Endocrinology.

[57]  H. Huynh,et al.  Kaempferol‐induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK‐MAPK , 2003, Journal of cellular physiology.

[58]  G. Stoner,et al.  Randomized Phase II Trial of Lyophilized Strawberries in Patients with Dysplastic Precancerous Lesions of the Esophagus , 2011, Cancer Prevention Research.

[59]  I. Herr,et al.  Targeting of pancreatic and prostate cancer stem cell characteristics by Crambe crambe marine sponge extract , 2012, International journal of cancer.

[60]  John Mohan,et al.  Caspase-2 Triggers Bax-Bak-dependent and -independent Cell Death in Colon Cancer Cells Treated with Resveratrol* , 2006, Journal of Biological Chemistry.

[61]  B. Pulendran,et al.  Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responses , 2007, Nature Immunology.

[62]  Pei-Wen Zheng,et al.  Apigenin induced apoptosis through p53-dependent pathway in human cervical carcinoma cells. , 2005, Life sciences.

[63]  K. Ahn,et al.  Induction of apoptosis by ethanolic extract of mango peel and comparative analysis of the chemical constitutes of mango peel and flesh. , 2012, Food chemistry.

[64]  Y. Kwon,et al.  Antioxidant constituents from the stem ofSorghum bicolor , 2003, Archives of pharmacal research.

[65]  Abigail S. Engelberth,et al.  Extraction of Co-Products from Biomass: Example of Thermal Degradation of Silymarin Compounds in Subcritical Water , 2009, Applied biochemistry and biotechnology.

[66]  Zhiwei Wang,et al.  The role of nutraceuticals in the regulation of Wnt and Hedgehog signaling in cancer , 2010, Cancer and Metastasis Reviews.

[67]  G. Wakabayashi,et al.  Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase , 2011, Breast Cancer Research and Treatment.

[68]  A. Ismail,et al.  Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats. , 2008, Journal of agricultural and food chemistry.

[69]  E. Larsson,et al.  Antioxidants Accelerate Lung Cancer Progression in Mice , 2014, Science Translational Medicine.

[70]  H. Mukhtar,et al.  Modulation of Wnt/β-catenin signaling pathway by bioactive food components. , 2012, Carcinogenesis.

[71]  A. Tyner,et al.  Induction of cell cycle arrest and apoptosis in HT-29 human colon cancer cells by the dietary compound luteolin. , 2007, American journal of physiology. Gastrointestinal and liver physiology.

[72]  Rajnish A. Gupta,et al.  Colorectal cancer prevention and treatment by inhibition of cyclooxygenase-2 , 2001, Nature Reviews Cancer.

[73]  T. Pischon,et al.  Obesity and colorectal cancer. , 2013, Frontiers in bioscience.

[74]  I. Taha,et al.  On the characterisation of structure and properties of sorghum stalks , 2013 .

[75]  J. G. Marshall,et al.  Resistance of certain grain sorghum hybrids to bird damage in Louisiana. , 1970 .

[76]  Y. Wong,et al.  Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism , 2006, Cell Biology and Toxicology.

[77]  Tae Myoung Kim,et al.  Toxicological Evaluation and Anti-Inflammatory Activity of a Golden Gelatinous Sorghum Bran Extract , 2013, Bioscience, biotechnology, and biochemistry.

[78]  J. Hargrove,et al.  Anti-inflammatory activity of select sorghum (Sorghum bicolor) brans. , 2010, Journal of medicinal food.

[79]  S. Chapman,et al.  An assessment of the genetic relationship between sweet and grain sorghums, within Sorghum bicolor ssp. bicolor (L.) Moench, using AFLP markers , 2007, Euphytica.

[80]  E. Bandrés,et al.  MicroRNA‐451 Is Involved in the Self‐renewal, Tumorigenicity, and Chemoresistance of Colorectal Cancer Stem Cells , 2011, Stem cells.

[81]  G. Collins.  The next generation. , 2006, Scientific American.

[82]  A. Massey,et al.  The Dermal Layer of Sweet Sorghum (Sorghum bicolor) Stalk, a Byproduct of Biofuel Production and Source of Unique 3-Deoxyanthocyanidins, Has More Antiproliferative and Proapoptotic Activity than the Pith in p53 Variants of HCT116 and Colon Cancer Stem Cells. , 2014, Journal of agricultural and food chemistry.

[83]  P. McCann,et al.  Effects of α-Difluoromethylornithine and 5-Fluorouracil on the Proliferation of a Human Colon Adenocarcinoma Cell Line , 1983 .

[84]  G. Cooper-Driver,et al.  Phenolic acids and resistance to insect attack in Sorghum bicolor , 1979 .

[85]  A. Schieber,et al.  Phenolic acids and flavonoids in nonfermented and fermented red sorghum (Sorghum bicolor (L.) Moench). , 2010, Journal of agricultural and food chemistry.

[86]  V.M. Zohrabian,et al.  The antiproliferative effect of Quercetin in cancer cells is mediated via inhibition of the PI3K-Akt/PKB pathway. , 2006, Anticancer research.

[87]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.

[88]  J. Uribarri,et al.  Insulin resistance and type 2 diabetes in high-fat-fed mice are linked to high glycotoxin intake. , 2005, Diabetes.

[89]  M. Jackson,et al.  Green Tea Polyphenols Induce p53-Dependent and p53-Independent Apoptosis in Prostate Cancer Cells through Two Distinct Mechanisms , 2012, PloS one.

[90]  H. Haisma,et al.  The effects of γ‐interferon combined with 5‐fluorouracil or 5‐fluoro‐2′‐deoxyuridine on proliferation and antigen expression in a panel of human colorectal cancer cell lines , 1991, International journal of cancer.

[91]  Robert C. Wolpert,et al.  A Review of the , 1985 .

[92]  U. Das,et al.  Resveratrol potentiates grape seed extract induced human colon cancer cell apoptosis. , 2011, Frontiers in bioscience.

[93]  L. S. Yazan,et al.  Apoptosis and cell cycle arrest of human colorectal cancer cell line HT-29 induced by vanillin. , 2009, Cancer epidemiology.

[94]  Byong Chul Yoo,et al.  Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. , 2004, Cancer research.

[95]  J. Lotem,et al.  Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[96]  H. L. Kock,et al.  Effects of phenolics in sorghum grain on its bitterness, astringency and other sensory properties , 2007 .

[97]  E. Livingston,et al.  Colon cancer and apoptosis. , 2006, American journal of surgery.

[98]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[99]  I. Akande,et al.  Effects of aqueous extract of Sorghum bicolor on hepatic, histological and haematological indices in rats. , 2010 .

[100]  D. Jacobs,et al.  Food synergy: an operational concept for understanding nutrition. , 2009, The American journal of clinical nutrition.

[101]  C. Lo,et al.  Quantitative analysis of anticancer 3-deoxyanthocyanidins in infected sorghum seedlings. , 2007, Journal of agricultural and food chemistry.

[102]  Jian Yu,et al.  Chemoprevention by nonsteroidal anti-inflammatory drugs eliminates oncogenic intestinal stem cells via SMAC-dependent apoptosis , 2010, Proceedings of the National Academy of Sciences.

[103]  James B. Mitchell,et al.  Oxidative stress, redox, and the tumor microenvironment. , 2004, Seminars in radiation oncology.

[104]  S. Sekaran,et al.  Phyllanthus spp. Induces Selective Growth Inhibition of PC-3 and MeWo Human Cancer Cells through Modulation of Cell Cycle and Induction of Apoptosis , 2010, PloS one.

[105]  J. McNamara.  Cancer Stem Cells , 2007, Methods in Molecular Biology.

[106]  T. Toda,et al.  Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam. , 2010, Cancer Chemotherapy and Pharmacology.

[107]  H. Daniel,et al.  Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. , 2008, Journal of agricultural and food chemistry.

[108]  Yong-Yeon Cho,et al.  Eriodictyol Inhibits RSK2-ATF1 Signaling and Suppresses EGF-induced Neoplastic Cell Transformation* , 2010, The Journal of Biological Chemistry.

[109]  Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression. , 2000, Carcinogenesis.

[110]  L. Ferguson,et al.  Antioxidant and antigenotoxic effects of plant cell wall hydroxycinnamic acids in cultured HT-29 cells. , 2005, Molecular nutrition & food research.

[111]  G. Stoner.  Foodstuffs for Preventing Cancer: The Preclinical and Clinical Development of Berries , 2009, Cancer Prevention Research.

[112]  J. Reed,et al.  Phenolics, fibre and fibre digestibility in the crop residue from bird resistant and non-bird resistant sorghum varieties , 1987 .

[113]  A. Bode,et al.  Luteolin inhibits protein kinase C(epsilon) and c-Src activities and UVB-induced skin cancer. , 2010, Cancer research.

[114]  J. Awika,et al.  Properties of 3-deoxyanthocyanins from sorghum. , 2004, Journal of agricultural and food chemistry.

[115]  L. Giovannelli,et al.  Red wine polyphenols influence carcinogenesis, intestinal microflora, oxidative damage and gene expression profiles of colonic mucosa in F344 rats. , 2005, Mutation research.

[116]  A. Harvey,et al.  Differential susceptibility to obesity between male, female and ovariectomized female mice , 2009, Nutrition journal.

[117]  A. Kong,et al.  Modulatory Properties of Various Natural Chemopreventive Agents on the Activation of NF-κB Signaling Pathway , 2004, Pharmaceutical Research.

[118]  Luis Cisneros-Zevallos,et al.  Screening methods to measure antioxidant activity of sorghum (sorghum bicolor) and sorghum products. , 2003, Journal of agricultural and food chemistry.

[119]  Francesco Cherubini,et al.  The biorefinery concept: Using biomass instead of oil for producing energy and chemicals , 2010 .

[120]  A. Yılmaz,et al.  Evaluation of the effects of the flavonoid apigenin on apoptotic pathway gene expression on the colon cancer cell line (HT29). , 2011, Journal of medicinal food.

[121]  Peretz P. Friedmann,et al.  Current Status and Future Trends , 2001 .

[122]  Chi-Tang Ho,et al.  Modulation of inflammatory genes by natural dietary bioactive compounds. , 2009, Journal of agricultural and food chemistry.

[123]  P. Carlsson,et al.  Female Mice are Protected against High-Fat Diet Induced Metabolic Syndrome and Increase the Regulatory T Cell Population in Adipose Tissue , 2012, PloS one.

[124]  J. Lupton,et al.  Suppression of colon carcinogenesis by bioactive compounds in grapefruit. , 2006, Carcinogenesis.

[125]  Laura Herrero,et al.  Obesity, inflammation, and insulin resistance. , 2007, Gastroenterology.

[126]  A. Apel,et al.  Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. , 2008, Cancer research.

[127]  Russell J. Mumper,et al.  Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer Properties , 2010, Molecules.

[128]  J. Awika,et al.  Sorghum phytochemicals and their potential impact on human health. , 2004, Phytochemistry.

[129]  G. Pahlke,et al.  The substitution pattern of anthocyanidins affects different cellular signaling cascades regulating cell proliferation. , 2004, Molecular nutrition & food research.

[130]  L. Sobrevia,et al.  Mice Long-Term High-Fat Diet Feeding Recapitulates Human Cardiovascular Alterations: An Animal Model to Study the Early Phases of Diabetic Cardiomyopathy , 2013, PloS one.

[131]  T. Graham,et al.  Stem cells and their implications for colorectal cancer , 2011, Nature Reviews Gastroenterology &Hepatology.

[132]  Ronald L. Madl,et al.  Evaluation and characterization of sorghum biomass as feedstock for sugar production. , 2010 .

[133]  M. Harrison.  A Global Perspective , 2015, Bulletin of the history of medicine.

[134]  A. Dobrian,et al.  Oxidative Stress in a Rat Model of Obesity-Induced Hypertension , 2001, Hypertension.

[135]  G. Jensen,et al.  West African Sorghum bicolor leaf sheaths have anti-inflammatory and immune-modulating properties in vitro. , 2013, Journal of medicinal food.

[136]  M. Moyer,et al.  Chemoprevention of colorectal cancer by targeting APC-deficient cells for apoptosis , 2010, Nature.

[137]  Y. Kitagishi,et al.  Redox regulation of tumor suppressor PTEN in cancer and aging (Review). , 2013, International journal of molecular medicine.

[138]  T. Hsia,et al.  DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway. , 2008, Cancer letters.

[139]  Dong-Hyun Kim,et al.  High Fat Diet-Induced Gut Microbiota Exacerbates Inflammation and Obesity in Mice via the TLR4 Signaling Pathway , 2012, PloS one.

[140]  Li Lin,et al.  Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030 , 2011, British Journal of Cancer.

[141]  H. Clevers,et al.  APC, Signal transduction and genetic instability in colorectal cancer , 2001, Nature Reviews Cancer.

[142]  Ian D. Caterson,et al.  Increased Gut Permeability and Microbiota Change Associate with Mesenteric Fat Inflammation and Metabolic Dysfunction in Diet-Induced Obese Mice , 2012, PloS one.

[143]  S. Imaoka,et al.  Apigenin suppresses the expression of VEGF, an important factor for angiogenesis, in endothelial cells via degradation of HIF‐1α protein , 2004, FEBS letters.

[144]  W. Willett,et al.  Intakes of fruits, vegetables, and related nutrients and the risk of non-Hodgkin's lymphoma among women. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[145]  N. Hunt,et al.  Role of the Gut in Visceral Fat Inflammation and Metabolic Disorders , 2011, Obesity.

[146]  Ming-cheng Lin,et al.  Protective effects of Houttuynia cordata aqueous extract in mice consuming a high saturated fat diet. , 2013, Food & function.

[147]  Nihal Turkmen,et al.  Effects of extraction solvents on concentration and antioxidant activity of black and black mate tea polyphenols determined by ferrous tartrate and Folin–Ciocalteu methods , 2006 .

[148]  Paolo Vineis,et al.  Variety in Fruit and Vegetable Consumption and the Risk of Lung Cancer in the European Prospective Investigation into Cancer and Nutrition , 2010, Cancer Epidemiology, Biomarkers & Prevention.

[149]  G. Venturi,et al.  Comparison of two Sorghum genotypes for sugar and fiber production , 1998 .

[150]  Zigang Dong,et al.  Molecular targets of phytochemicals for cancer prevention , 2011, Nature Reviews Cancer.

[151]  Tosca L. Zern,et al.  Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. , 2005, The Journal of nutrition.

[152]  Michael Karin,et al.  Inflammation and colon cancer. , 2010, Gastroenterology.

[153]  L. J. Maher.  Potential Mechanisms of Action , 1999 .

[154]  S. Collin,et al.  Potentiality of red sorghum for producing stilbenoid-enriched beers with high antioxidant activity. , 2011, Journal of agricultural and food chemistry.

[155]  H. Clevers,et al.  Linking Colorectal Cancer to Wnt Signaling , 2000, Cell.

[156]  Mun Kyung Hwang,et al.  Caffeic acid, a phenolic phytochemical in coffee, directly inhibits Fyn kinase activity and UVB-induced COX-2 expression. , 2008, Carcinogenesis.

[157]  R. Lamuela-Raventós,et al.  Analysis of total phenols and other oxidation substrates and antioxidants by means of Folin-Ciocalteu reagent , 1999 .

[158]  S. Safe,et al.  Anthocyanin fraction from potato extracts is cytotoxic to prostate cancer cells through activation of caspase-dependent and caspase-independent pathways. , 2007, Carcinogenesis.

[159]  J. Awika,et al.  Processing of sorghum (Sorghum bicolor) and sorghum products alters procyanidin oligomer and polymer distribution and content. , 2003, Journal of agricultural and food chemistry.

[160]  P. Johnston,et al.  5-Fluorouracil: mechanisms of action and clinical strategies , 2003, Nature Reviews Cancer.

[161]  A. Hale,et al.  Determination of phenolic content, composition and their contribution to antioxidant activity in specialty potato selections , 2007, American Journal of Potato Research.

[162]  Xi He,et al.  Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. , 2002, Cell.

[163]  L. Rooney,et al.  Sorghum and millet phenols and antioxidants , 2006 .

[164]  D. McMillan,et al.  Use of Inflammatory Markers to Guide Cancer Treatment , 2011, Clinical pharmacology and therapeutics.

[165]  L. Reddivari,et al.  Storage elevates phenolic content and antioxidant activity but suppresses antiproliferative and pro-apoptotic properties of colored-flesh potatoes against human colon cancer cell lines. , 2011, Journal of agricultural and food chemistry.

[166]  C. Lelliott,et al.  Intestinal, adipose, and liver inflammation in diet-induced obese mice. , 2008, Metabolism: clinical and experimental.

[167]  J. Awika,et al.  Sorghum 3-deoxyanthocyanins possess strong phase II enzyme inducer activity and cancer cell growth inhibition properties. , 2009, Journal of agricultural and food chemistry.

[168]  F. Nwinyi,et al.  Evaluation of aqueous methanolic extract of Sorghum bicolor leaf base for antinociceptive and anti- inflammatory activities , 2009 .

[169]  G. Loo.  Redox-sensitive mechanisms of phytochemical-mediated inhibition of cancer cell proliferation (review). , 2003, The Journal of nutritional biochemistry.

[170]  É. A. Moraes,et al.  Sorghum genotype may reduce low-grade inflammatory response and oxidative stress and maintains jejunum morphology of rats fed a hyperlipidic diet , 2012 .

[171]  B. Geiger,et al.  Excess β‐catenin promotes accumulation of transcriptionally active p53 , 1999, The EMBO journal.