The roles of inflammation and immune mechanisms in Alzheimer's disease
暂无分享,去创建一个
M. Carrillo | J. Molinuevo | P. Cole | R. Ransohoff | D. Wilcock | R. Margolin | B. Greenberg | L. Bain | K. Bales | L. V. Van Eldik | M. Kennedy | James A. Hendrix | D. Feuerbach | R. Mueller | N. Kozauer | Nicholas A. Kozauer
[1] A. Najafi,et al. Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology. , 2016, Brain : a journal of neurology.
[2] C. Granziera,et al. In Vivo Imaging of Human Neuroinflammation. , 2016, ACS chemical neuroscience.
[3] K. Blennow,et al. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers , 2016, EMBO molecular medicine.
[4] J. Molinuevo,et al. CSF YKL-40 and pTau181 are related to different cerebral morphometric patterns in early AD , 2016, Neurobiology of Aging.
[5] Stephen F. Carter,et al. Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease , 2016, Brain : a journal of neurology.
[6] Kazuki Harada,et al. Gliotransmitter Release from Astrocytes: Functional, Developmental, and Pathological Implications in the Brain , 2016, Front. Neurosci..
[7] K. Blennow,et al. Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer’s disease , 2016, Molecular Neurodegeneration.
[8] L. Wilkins. Etanercept in Alzheimer disease: A randomized, placebo-controlled, double-blind, phase 2 trial , 2015, Neurology.
[9] D. Rujescu,et al. The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease , 2015, Alzheimer's & Dementia.
[10] M. Guillot-Sestier,et al. Innate Immunity Fights Alzheimer's Disease , 2015, Trends in Neurosciences.
[11] B. Stevens,et al. Microglia Function in Central Nervous System Development and Plasticity. , 2015, Cold Spring Harbor perspectives in biology.
[12] Chengjie Xiong,et al. Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age. , 2015, JAMA neurology.
[13] M. Tansey,et al. Inflammation in nervous system disorders , 2015, Neuroscience.
[14] M. Guillot-Sestier,et al. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive? , 2015, Brain Research.
[15] Joel T Dudley,et al. Mapping the effects of drugs on the immune system , 2015, Nature Biotechnology.
[16] G. Réus,et al. The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders , 2015, Neuroscience.
[17] A. Palmeri,et al. Rodent models for Alzheimer’s disease drug discovery , 2015, Expert opinion on drug discovery.
[18] David Bartrés-Faz,et al. Relationship between cortical thickness and cerebrospinal fluid YKL-40 in predementia stages of Alzheimer's disease , 2015, Neurobiology of Aging.
[19] Guixiang Xu,et al. Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain. , 2015, Brain : a journal of neurology.
[20] Burkhard Becher,et al. Immune attack: the role of inflammation in Alzheimer disease , 2015, Nature Reviews Neuroscience.
[21] M. Lynch,et al. T Cells—Protective or Pathogenic in Alzheimer’s Disease? , 2015, Journal of Neuroimmune Pharmacology.
[22] Andrew N Hoofnagle,et al. Arginine Deprivation and Immune Suppression in a Mouse Model of Alzheimer's Disease , 2015, The Journal of Neuroscience.
[23] O. Garaschuk,et al. Neuroinflammation in Alzheimer's disease , 2015, The Lancet Neurology.
[24] H. Stefánsson,et al. Loss-of-function variants in ABCA7 confer risk of Alzheimer's disease , 2015, Nature Genetics.
[25] S. Younkin,et al. Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia. , 2015, Human molecular genetics.
[26] R. Ransohoff,et al. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models , 2015, The Journal of experimental medicine.
[27] Charles C. White,et al. A TREM1 variant alters the accumulation of Alzheimer‐related amyloid pathology , 2015, Annals of neurology.
[28] Nathan D. Price,et al. IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior , 2015, Neuron.
[29] M. Guillot-Sestier,et al. Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology , 2015, Neuron.
[30] R. Petersen,et al. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural‐derived blood exosomes of preclinical Alzheimer's disease , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[31] G. Taglialatela,et al. NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease , 2015, Neuron.
[32] M. Schwartz,et al. Breaking peripheral immune tolerance to CNS antigens in neurodegenerative diseases: boosting autoimmunity to fight-off chronic neuroinflammation. , 2014, Journal of autoimmunity.
[33] Steffen Jung,et al. Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway , 2014, The Journal of Neuroscience.
[34] J. Molinuevo,et al. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis , 2014, Science Translational Medicine.
[35] E. Lander,et al. Development and Applications of CRISPR-Cas9 for Genome Engineering , 2014, Cell.
[36] Daphne Koller,et al. Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes , 2014, Science.
[37] P. Sanberg,et al. The innate and adaptive immunological aspects in neurodegenerative diseases , 2014, Journal of Neuroimmunology.
[38] S. Hickman,et al. TREM2 and the neuroimmunology of Alzheimer's disease. , 2014, Biochemical pharmacology.
[39] Marco Prinz,et al. Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease , 2014, Nature Reviews Neuroscience.
[40] F. Schmitt,et al. Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models , 2014, Front. Genet..
[41] E. Schadt,et al. Unifying immunology with informatics and multiscale biology , 2014, Nature Immunology.
[42] Sid O'Bryant,et al. Developing novel blood-based biomarkers for Alzheimer's disease , 2014, Alzheimer's & Dementia.
[43] Magda Tsolaki,et al. Candidate blood proteome markers of Alzheimer's disease onset and progression: a systematic review and replication study. , 2013, Journal of Alzheimer's disease : JAD.
[44] Toshiro K. Ohsumi,et al. The Microglial Sensome Revealed by Direct RNA Sequencing , 2013, Nature Neuroscience.
[45] M. Franceschi,et al. CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study. , 2013, Current Alzheimer research.
[46] Manasi Malik,et al. CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing , 2013, The Journal of Neuroscience.
[47] Francis J McMahon,et al. In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease. , 2013, Brain : a journal of neurology.
[48] D. Wesson,et al. Response to Comments on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” , 2013, Science.
[49] Keith A. Johnson,et al. CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology , 2013, Nature Neuroscience.
[50] Bradley T. Hyman,et al. Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta , 2013, Neuron.
[51] L. Tran,et al. Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease , 2013, Cell.
[52] Pasko Rakic,et al. A Transgenic Alzheimer Rat with Plaques, Tau Pathology, Behavioral Impairment, Oligomeric Aβ, and Frank Neuronal Loss , 2013, The Journal of Neuroscience.
[53] F. Schmitt,et al. Neuroinflammatory phenotype in early Alzheimer's disease , 2013, Neurobiology of Aging.
[54] C. Rowe,et al. Amyloid β deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: a prospective cohort study , 2013, The Lancet Neurology.
[55] Henrik Zetterberg,et al. Plasma tau levels in Alzheimer's disease , 2013, Alzheimer's Research & Therapy.
[56] F. LaFerla,et al. Sustained Interleukin-1β Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model , 2013, The Journal of Neuroscience.
[57] D. Morgan,et al. Review: Experimental manipulations of microglia in mouse models of Alzheimer's pathology: activation reduces amyloid but hastens tau pathology , 2013, Neuropathology and applied neurobiology.
[58] C. Holmes. Review: Systemic inflammation and Alzheimer's disease , 2013, Neuropathology and applied neurobiology.
[59] A. Hofman,et al. Variant of TREM2 associated with the risk of Alzheimer's disease. , 2013, The New England journal of medicine.
[60] York Winter,et al. Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease–like pathology and cognitive decline , 2012, Nature Medicine.
[61] Murray Grossman,et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease , 2012, Neurology.
[62] Donald A. Wilson,et al. ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models , 2012, Science.
[63] N. Greig,et al. Targeting TNF-Alpha to Elucidate and Ameliorate Neuroinflammation in Neurodegenerative Diseases , 2011 .
[64] G. Gowing,et al. How to get from here to there: macrophage recruitment in Alzheimer's disease. , 2011, Current Alzheimer research.
[65] Chengjie Xiong,et al. YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease , 2010, Biological Psychiatry.
[66] R. Ransohoff,et al. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. , 2010, The American journal of pathology.
[67] Ania K. Majewska,et al. Microglial Interactions with Synapses Are Modulated by Visual Experience , 2010, PLoS biology.
[68] M. Nedergaard,et al. Functions of astrocytes and their potential as therapeutic targets , 2010, Neurotherapeutics.
[69] C. Colton,et al. Assessing activation states in microglia. , 2010, CNS & neurological disorders drug targets.
[70] D. Holtzman,et al. ApoE Promotes the Proteolytic Degradation of Aβ , 2008, Neuron.
[71] Jun Tan,et al. Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology , 2008, Nature Medicine.
[72] C. Geula,et al. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease , 2007, Nature Medicine.
[73] S. Goodman,et al. Nonsteroidal Anti-Inflammatory Drugs for the Prevention of Alzheimer’s Disease: A Systematic Review , 2004, Neuroepidemiology.
[74] H. Gendelman,et al. Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[75] G. Forloni,et al. The Continuing Failure of Bexarotene in Alzheimer's Disease Mice. , 2015, Journal of Alzheimer's disease : JAD.
[76] E. Lander,et al. Development and Applications of CRISPR-Cas 9 for Genome Engineering , 2015 .
[77] K. Shudo,et al. Cooperative therapeutic action of retinoic acid receptor and retinoid x receptor agonists in a mouse model of Alzheimer's disease. , 2014, Journal of Alzheimer's disease : JAD.
[78] Xi Chen,et al. Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro®1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats. , 2014, Journal of Parkinson's disease.
[79] D. Galimberti,et al. Gender effects on plasma PGRN levels in patients with Alzheimer's disease: a preliminary study. , 2013, Journal of Alzheimer's disease : JAD.
[80] M. Franceschi,et al. CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo-Controlled Study. , 2013, Current Alzheimer research.
[81] M. Sporn,et al. The Retinoids : biology, chemistry, and medicine , 1994 .
[82] A. Alzheimer. Uber eine eigenartige Erkrankung der Hirnrinde , 1907 .