A Whole Body Thenmal Model of Man During Hyperthermia

A whole body thermal model of man has been developed to predict the changes in regional temperatures and blood flows during hyperthermia treatments with the miniannular phased array (MAPA) and annular phased array (APA) applicators. A model of the thermo-regulatory response to regional heating based on the experimental and numerical studies of others has been incorporated into this study. Experimentally obtained energy deposition patterns within a human leg exposed to the MAPA were input into the model and the results were compared to those based upon a theoretical deposition pattern. Exposure of the abdomen to the APA was modeled with and without the aberrant energy deposition that has been described previously. Results of the model reveal that therapeutic heating (42°C) of extremity soft tissue sarcomas is possible without significant systemic heating. Very high bone temperatures (50°C) were obtained when the experimental absorption pattern was used. Calculations show that systemic heating due to APA exposure is reduced via evaporative spray cooling techniques coupled with high-velocity ambient air flow.

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